Curcumin self-microemulsion and preparation method thereof

Abstract

The invention discloses a self-microemulsion, in particular to a curcumin self-microemulsion and a preparation method thereof. The curcumin self-microemulsion is characterized by the following components by weight percent: 0.05%-10% of curcumin, 1%-35% of oil phase, 20%-80% of surfactant, and 2%-40% of cosurfactant. The curcumin self-microemulsion and the preparation method thereof has the benefits that: a curcumin self-microemulsion release system increases the solubility of drugs, protects the drugs dissolved in oil drops, and improves the stability in a body; and the surfactant can change the flowability of cell membranes, improve membrane permeability of the drugs, enhance the absorption of the drugs in the body and increase the relative bioavailability of oral drugs.

Description

(1) Technical field

[0001] The invention relates to a self-microemulsion, in particular to a curcuminoid self-microemulsion and a preparation method thereof. (2) Background technology

[0002] Curcumin is an effective part isolated from the underground rhizomes of turmeric (curcuma longa L.), turmeric (curcuma wenyujin Y.H.Chen et C.Ling) and curcuma (Curcuma phaeocaulis Val.). It is a kind of natural linear diaryl heptanone compound, from which three active ingredients can be separated: curcumin, demethoxycurcumin and bisdemethoxycurcumin. Curcuminoids are often used as pigments and flavoring additives of various foods, and have a wide range of biological activities such as anti-tumor, hypolipidemic, anti-atherosclerosis, anti-inflammation, and anti-oxidation. However, the solubility of curcuminoids in water is small, and their aqueous solutions are unstable under neutral and alkaline conditions. After oral administration of curcuminoids, the plasma concentration is low a...

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