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Compound thermo-sensitive liposome used for thermal targeted chemotherapy and preparation method thereof

A technology of compound heat-sensitive lipid and heat-sensitive liposome is applied in the field of medicine to achieve the effects of accurate temperature control, improved effect and elimination of complications

Inactive Publication Date: 2010-11-24
天津市第一中心医院 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there is no published research on the use of thermal targeted chemotherapy under CT temperature measurement and control in the treatment of tumors at home and abroad.

Method used

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  • Compound thermo-sensitive liposome used for thermal targeted chemotherapy and preparation method thereof
  • Compound thermo-sensitive liposome used for thermal targeted chemotherapy and preparation method thereof
  • Compound thermo-sensitive liposome used for thermal targeted chemotherapy and preparation method thereof

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Effect test

Embodiment 1

[0036] The preparation of embodiment 1 compound thermosensitive liposome freeze-dried product 1

[0037] prescription:

[0038] Lomustine 112.5mg

[0039] DPPC 2250mg

[0040] V E 112.5mg

[0041] Iohexol 26.4g

[0042] Chloroform 225ml

[0043] Phosphate buffer to 75ml

[0044] Take lomustine, DPPC and V E Put it in an eggplant-shaped bottle, add chloroform to dissolve it, put another iohexol in a beaker, add an appropriate amount of phosphate buffer solution to dissolve it, add phosphate buffer solution to 75ml, put the two kinds of liquid containers in a water bath at 45°C, Shake until the temperature is balanced, sonicate, and drop the iohexol solution into the chloroform solution at the same time, shake the chloroform solution while adding dropwise, to make the emulsification even, after adding the iohexol, shake and sonicate for 2 minutes. Evaporate the emulsion by rotary evaporation, the temperature of the water bath is 45°C, and the vacuum degree is contr...

Embodiment 2

[0047] The preparation 2 of embodiment 2 compound thermosensitive liposome freeze-dried product

[0048] prescription:

[0049] 5-fluorouracil 12.5g

[0050] DPPC 3.6g

[0051] PG0.4g

[0052] V E 150mg

[0053] Iopamidol 50.2g

[0054] Chloroform 400ml

[0055] Phosphate buffer to 100ml

[0056] Take DPPC, PG and V E Put it in an eggplant-shaped bottle, add chloroform to dissolve it, put 5-fluorouracil and iopamidol in a beaker, add an appropriate amount of phosphate buffer solution to dissolve, add phosphate buffer solution to 100ml, put the two kinds of liquid medicine containers in 40 In a water bath at ℃, shake until the temperature is balanced, and sonicate. At the same time, take the aqueous phase solution and drop it into the chloroform solution. While adding the solution, shake the chloroform solution to make the emulsification uniform. After adding the aqueous phase solution, shake and sonicate for 2 minutes. Evaporate the emulsion by rotary evapor...

Embodiment 3

[0059] The preparation of embodiment 3 compound thermosensitive liposome freeze-dried product 3

[0060] prescription:

[0061] Doxorubicin Hydrochloride 500mg

[0062] DPPC 4.0g

[0063] PS 1.0g

[0064] V E 150mg

[0065] Iodixanol 40.1g

[0066] Chloroform-ether mixture (5:1) 300ml

[0067] Phosphate buffer to 100ml

[0068] Take DPPC, PS and V E Put it in an eggplant-shaped bottle, add chloroform-ether mixed solvent to dissolve, take another doxorubicin hydrochloride and iodixanol in a beaker, add an appropriate amount of phosphate buffer to dissolve, add phosphate buffer to 100ml, and put two Put the liquid medicine container in a water bath at 42°C, shake until the temperature is balanced, and ultrasonically, and at the same time, take the aqueous phase solution and drop it into the chloroform-ether mixed solvent solution, shake the chloroform-ether mixed solvent solution while adding, to make the emulsification uniform, After adding the aqueous phas...

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Abstract

The invention provides a compound thermo-sensitive liposome containing a CT contrast agent and tumor chemotherapy medicaments, and a method for preparing the compound thermo-sensitive liposome. The novel compound thermo-sensitive liposome provided by the invention can be applied to thermal targeted chemotherapy, particularly thermal targeted chemotherapy at CT measurement and control temperature, can make the temperature control of thermal therapy more accurate, greatly reduce the side effect of the thermal therapy and the thermal injury to normal tissues, and improve the effect of the thermal therapy; meanwhile, the synchronous thermal targeted chemotherapy obviously enhances the effect of the thermal therapy and reduces the toxic and side effects of systemic chemotherapy; therefore, the compound thermo-sensitive liposomes has good social benefit.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a thermosensitive liposome used in thermotargeted chemotherapy. technical background [0002] For half a century, oncology has made great progress in the world and in my country. The comprehensive application of existing possible methods to treat tumors has been deeply rooted in the hearts of the people and accepted by tumor clinicians. Comprehensive treatment has become the best treatment for tumors. and the most popular models. The cooperation among surgical treatment, radiotherapy, chemotherapy, hyperthermia and biological therapy has achieved remarkable curative effect in the treatment of various tumors. [0003] Hyperthermia, as an auxiliary method for the treatment of malignant tumors, has the characteristics that other treatment methods do not have: low cost, few side effects, can stimulate tumor immunity, and has a certain curative effect. Chemotherapy is also one of the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K47/24A61K47/16A61P35/00
Inventor 张丙杰杨志强高晶李牧王杏林
Owner 天津市第一中心医院
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