Ursodeoxycholic acid phospholipid composition and preparation method thereof

A technology of oxycholic acid phospholipid and ursodeoxycholic acid, which is applied in the field of medicine and can solve problems such as poor absorption

Inactive Publication Date: 2010-12-01
BEIJING SUNHO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Ursodeoxycholic acid is practically insoluble in water and is poorly absorbed when administered orally

Method used

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  • Ursodeoxycholic acid phospholipid composition and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Study on the therapeutic effect of ursodeoxycholic acid phospholipid composition on gallstones in guinea pigs induced by high cholesterol.

[0023] Sixty female healthy guinea pigs were randomly divided into 5 groups, 10 in each group.

[0024] (1) Normal group: the rats were killed after being fed a normal diet for 6 weeks.

[0025] (2) Positive group: fed a high-cholesterol diet (0.5% cholesterol was added to the normal diet) for 6 weeks and then killed.

[0026] (3) Treatment group A: After feeding the same high-cholesterol diet as the positive group for 6 weeks, they were fed a normal diet plus ursodeoxycholic acid for 6 weeks at a dose of 40 mg / (kg·d), and fed regularly and quantitatively.

[0027] (4) Treatment of group B: After feeding the same high-cholesterol diet as the positive group for 6 weeks, change to a normal diet plus ursodeoxycholic acid phospholipid composition (ursodeoxycholic acid and soybean phospholipid weight ratio 1:3) for 6 weeks , the dose ...

Embodiment 2

[0035] Study on the therapeutic effect of ursodeoxycholic acid phospholipid composition on alcoholic fatty liver in rats.

[0036] Get 40 SD rats, male, body weight 200 ± 20g, randomly divided into normal group, positive group, ursodeoxycholic acid group (treatment A group) and ursodeoxycholic acid phospholipid complex group (treatment B group), 10 in each group. Except for the normal group, the other groups used 50% ethanol to make models at 12ml / KgBW; the treatment group A was given ursodeoxycholic acid by intragastric administration at the same time, and the dose was 50mg / Kg / d; Deoxycholic acid phospholipid composition (ursodeoxycholic acid and soybean phospholipid weight ratio 1:2). After 6 consecutive weeks of the above model and drug administration groups, oil red 0 staining of rat liver tissue was performed to detect liver cell lipid droplets under a light microscope, and the results are shown in Table 2.

[0037] Table 2 Effect of ursodeoxycholic acid phospholipid co...

Embodiment 3

[0041] The preparation of medicine of the present invention:

[0042] Weigh 10 g of ursodeoxycholic acid, add 50 g of 95% ethanol, and heat to dissolve it to obtain ursodeoxycholic acid solution. Weigh 10 g of soybean lecithin, add 70 g of 95% ethanol, and heat to dissolve it to obtain a soybean lecithin solution. Combine the ursodeoxycholic acid solution and the soybean lecithin solution prepared above, mix them evenly, and concentrate to dryness under reduced pressure to obtain the ursodeoxycholic acid phospholipid composition.

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PUM

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Abstract

The invention relates to an ursodeoxycholic acid phospholipid composition, which consists of ursodeoxycholic acid and phospholipid, wherein the weight ratio of the ursodeoxycholic acid to the phospholipid is 1:1-5. The invention also discloses a preparation method for the ursodeoxycholic acid phospholipid composition. The method has simple operation and low cost. The ursodeoxycholic acid phospholipid composition prepared by using the method can remarkably improve the effect of the ursodeoxycholic acid on the aspects of protecting the liver and benefiting the gallbladder. The ursodeoxycholic acid phospholipid composition is used for treating liver and gallbladder diseases such as fatty liver, liver cirrhosis, gallstone and the like.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a ursodeoxycholic acid phospholipid composition and a preparation method thereof. Background technique [0002] Ursodeoxycholic acid (UDCA) is a hydrophilic dihydroxycholic acid (chemical structure: 3α, 7β-dihydroxy-5βcholic acid). In the early days, it was isolated from bear bile, and now ursodeoxycholic acid can be obtained by chemical synthesis. Modern pharmacological studies have proved that bear bile has the functions of clearing heat and detoxifying, protecting liver and promoting gallbladder, antibacterial and anti-inflammatory, sedative and anticonvulsive, relieving spasm and analgesia, removing nebula and improving eyesight, etc. The acute toxicity is very small, and it is effective for human liver and gallbladder diseases and ophthalmic diseases. It has also achieved remarkable results in the treatment of many diseases such as cardiovascular and cerebrovascular diseas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/685A61K31/575A61K36/48A61P1/16
Inventor 张树祥范宇宁
Owner BEIJING SUNHO PHARMA
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