Unlock instant, AI-driven research and patent intelligence for your innovation.

Preparation method of silver yellow medicinal preparation containing polyethylene glycol 12-hydroxy stearate

A technology of polyethylene glycol dodecyl hydroxystearate and pharmaceutical preparations, which is applied in the field of medicine, can solve problems such as being unable to meet actual clinical needs, and achieves the effects of facilitating clinical medication and promotion, and improving clarity.

Active Publication Date: 2013-07-31
SICHUAN SUNNYHOPE PHARM CO LTD
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, using the above methods to obtain injections still cannot satisfactorily solve the problems of precipitation and turbidity of Danshen injection during placement, and cannot meet the actual clinical needs.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of silver yellow medicinal preparation containing polyethylene glycol 12-hydroxy stearate
  • Preparation method of silver yellow medicinal preparation containing polyethylene glycol 12-hydroxy stearate
  • Preparation method of silver yellow medicinal preparation containing polyethylene glycol 12-hydroxy stearate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A silver yellow pharmaceutical preparation containing polyethylene glycol lauryl hydroxystearate, which is mainly composed of honeysuckle extract, scutellaria baicalensis extract and polyethylene glycol lauryl hydroxystearate for improving the clarity of injection. For the medicine for injection made from water for injection, the dosage of polyethylene glycol lauryl hydroxystearate is 0.1g-1.0g / 100ml.

[0029] The preparation method of above-mentioned Yinhuang pharmaceutical preparation is as follows:

[0030] Scutellaria baicalensis extract 20.0g (calculated as baicalin)

[0031] Honeysuckle extract 12.5g (calculated as chlorogenic acid)

[0032] 2.0g

[0033] For the above two flavors, add water for injection and 80% sodium hydroxide solution to dissolve in an appropriate amount, mix, add water for injection to about 980ml, adjust the pH value to 7.2 with 80% sodium hydroxide solution, add an appropriate amount of activated carbon, and heat on a wat...

Embodiment 2

[0035] Scutellaria baicalensis extract 20.0g (calculated as baicalin)

[0036] Honeysuckle extract 12.5g (calculated as chlorogenic acid)

[0037] 2.0g

[0038] For the above two flavors, add water for injection and 80% sodium hydroxide solution to dissolve in an appropriate amount, mix, add water for injection to about 500ml, adjust the pH value to 7.2 with 80% sodium hydroxide solution, add an appropriate amount of activated carbon, and heat on a water bath for 1 hour, let cool, add polyethylene glycol lauryl hydroxystearate, and adjust to a certain volume of solution with water for injection. Adjust the pH value to 7.2 with 80% sodium hydroxide solution, and filter the solution through a microporous membrane. Subpackaged, freeze-dried, that is.

Embodiment 3

[0040] Polysorbate 80 (ie Tween 80) and Solutol Comparative Test of Stability of Solubilized Yinhuang Injection

[0041]The solution stability of the Yinhuang injection prepared by the present invention is very good, which solves the problems that the Yinhuang injection is prone to small white spots, precipitation and solution turbidity during storage and high-temperature sterilization. According to the relevant requirements of the Chinese Pharmacopoeia 2005 edition two appendix XI XC pharmaceutical preparations stability test guidelines, the obtained Yinhuang injection was placed at 25°C for 36 months, at 40°C for 6 months, and at 60°C for 20 days. The stability of the medicine, the result is stable product quality under the above-mentioned test conditions, and each test index all meets the regulation of this product quality standard.

[0042] The results of pharmacological experiments show that the Yinhuang injection prepared by the present invention has no hemolyticity, n...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a silver yellow medicinal preparation containing polyethylene glycol 12-hydroxy stearate and a preparation method thereof. The silver yellow medicinal preparation is an injection medicament which is mainly prepared by dissolving a honeysuckle flower extract, a baical skullcap root extract and the polyethylene glycol 12-hydroxy stearate for enhancing the clarity of injection in water for injection, wherein the dosage of the polyethylene glycol 12-hydroxy stearate is between 0.1 and 1.0 g / 100ml. Under the condition that the silver yellow medicinal preparation is stored for a long time (more than 24 months), the clarity of the silver yellow medicinal preparation can be enhanced, the detection of visible foreign matters of the injection can be stably kept in accordancewith the specification of medicament quality standard, the problems of a small number of small white points, white blocks and solution turbidness of the injection occurring under the condition that the silver yellow medicinal preparation is stored by using the conventional cosolvent (Twain-80) for a long time are solved, the detection of the visible foreign matters of the injection can be ensuredin accordance with the specification of the medicament quality standard, and convenience is brought to clinical administration and popularization.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a silvery yellow pharmaceutical preparation containing polyethylene glycol lauryl hydroxystearate. Background technique [0002] The standard of Yinhuang injection is recorded in the drug standard issued by the Ministry of Health (WS3-B-3691-98, traditional Chinese medicine preparation), and the raw materials are 20.0g of Scutellaria baicalensis extract (calculated as baicalin), and 12.5g of honeysuckle extract (calculated as baicalin). Chlorogenic acid meter). For the above two flavors, add water for injection and 80% sodium hydroxide solution to dissolve in an appropriate amount, mix, add water for injection to about 980ml, adjust the pH value to 7.2 with 80% sodium hydroxide solution, add an appropriate amount of activated carbon, and heat on a water bath for 1 hours, let cool, add 10ml of benzyl alcohol, adjust to 1000ml with water for injection, filter, pot, an...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/539A61K47/34A61K9/08A61K9/19A61P11/04A61P11/14A61K47/14
Inventor 郭成辉毛长兴陈开军舒赟蒋巧梅李萍
Owner SICHUAN SUNNYHOPE PHARM CO LTD