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Tissue-like manufacture die based on spheroid elementary unit and preparation process

A technology of basic unit and preparation process, applied in the direction of prosthesis, medical science, etc., can solve the problem that the stent manufacturing method cannot be satisfied, and achieve the effect of easy mass production

Inactive Publication Date: 2010-12-08
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Traditional stent manufacturing methods cannot meet the needs of engineering, standardization, and mass production of such stents

Method used

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  • Tissue-like manufacture die based on spheroid elementary unit and preparation process
  • Tissue-like manufacture die based on spheroid elementary unit and preparation process
  • Tissue-like manufacture die based on spheroid elementary unit and preparation process

Examples

Experimental program
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Embodiment Construction

[0017] refer to figure 1 As shown, this type of tissue has an internal channel structure, which is used to simulate the blood vessels, material flow, exchange, etc. between natural cells. The spherical unit has independent channels that simulate the cell structure, and can be connected with other units to form a larger Scaffold or class tissue.

[0018] refer to figure 2 , image 3 The upper and lower mold cavities of the mold for pressing the spherical unit are respectively provided with positioning pins and positioning holes. There is a certain gap between the two. The positioning pins can also be used to press the inner channel of the spherical unit. The upper die has an upper hemispherical cavity and positioning guide posts; the lower die has a lower hemispherical cavity and a positioning counterbore.

[0019] refer to Figure 4 As shown, the mold base is used to install the upper and lower mold cavities. Specific process combined with image 3 The description is as...

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Abstract

The invention discloses a tissue-like manufacture die based on a spheroid elementary unit and a preparation process. The invention mainly comprises that small balls with internal channels are used as elementary units to construct a compound body of brackets, cells and growth factors, i.e. millimeter-sized small balls with internal channels are constructed through a pressing method, then larger cell and bracket like tissues are constructed through a plurality of small ball elementary units, and the prepared compound can be further used for culturing in vitro or being directly implanted into the body.

Description

technical field [0001] The invention relates to a quasi-tissue structure mold and a manufacturing process thereof, in particular to a quasi-tissue manufacturing mold and a preparation process based on spherical basic units. Background technique [0002] Tissue engineering provides an effective means to solve the shortage of organ transplant donors, and it becomes possible to culture living tissues in vitro. In order to achieve more biochemical functions of human organs, tissue engineering not only has specific requirements for the scaffold structure, but also requires smooth material metabolism and information transmission after implantation in the human body, and more importantly, rapid vascularization. Therefore, it is required that there should be an internal channel structure in the stent to facilitate vascularization and proliferation between cells. There must be both connections and gaps between the scaffolds, which can meet the space and information transmission requ...

Claims

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Application Information

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IPC IPC(8): A61F2/02A61L27/38A61L27/54A61L27/24A61L27/18A61L27/20A61L27/22
Inventor 高琨刘亚雄李涤尘连芩赵倩卢秉恒
Owner XI AN JIAOTONG UNIV
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