New usage of formononetin-3'-sodium sulfonate

A technology of formononetin and sodium sulfonate, applied in medical preparations containing active ingredients, cardiovascular system diseases, organic active ingredients, etc.

Inactive Publication Date: 2010-12-08
SHANDONG GREENERY NATURAL MEDICINE RES & DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no literature report on its application in the treatment of cardiovascular diseases. The inventors have provided the application of formononetin-3'-sodium sulfonate in the preparation of drugs for the treatment or prevention of cardiovascular diseases through a large number of experimental studies.

Method used

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  • New usage of formononetin-3'-sodium sulfonate
  • New usage of formononetin-3'-sodium sulfonate
  • New usage of formononetin-3'-sodium sulfonate

Examples

Experimental program
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Effect test

preparation example 1

[0023] Preparation Example 1 Preparation of formononetin-3'-sodium sulfonate

[0024] Add 3 kg of formononetin (purchased from Xi'an Yangling Dongke Madison Pharmaceutical Company, batch number 081211, content 98.5%) into the reaction kettle, stir with a mixer and gradually add solvent 80% sulfuric acid until formononetin is fully dissolved, and then Add sulfonating agent 98% concentrated sulfuric acid, and the molar ratio of formononetin to sulfonating agent is 1:5. After stirring with a mixer, use a temperature adjusting device to make the temperature of the reaction solution 60°C and react for 6 hours to obtain formononetia The mixture of Su-3′-sulfonic acid and unreacted raw materials is cooled to room temperature, and a 10% sodium chloride aqueous solution of 5 times the total volume of the reactants is added, fully stirred, and left to stand to precipitate a white precipitate, which is filtered to obtain formononetin -3′-Sodium Sulfonate Crude Product; Use the recrystalliza...

preparation example 2

[0025] Preparation Example 2 Preparation of Formononetin-3'-Sodium Sulfonate Injection

[0026] Prescription: Formononetin-3'-sodium sulfonate 5.0g

[0027] Sodium chloride 8.9g

[0028] Water for injection 1000ml

[0029]

[0030] Make 1000ml

[0031] Preparation method: Take formononetin-3'-sodium sulfonate 5.0g and sodium chloride 8.9g according to the prescription, dissolve with 1000ml water for injection, stir; add 50g activated carbon, stir for 20 minutes, and filter the solution through a microporous membrane Clear, packed in 25ml vials, 10ml per bottle, sterilized, and packed after inspection. Other inspection items should meet the requirements of the 2005 edition of the Chinese Pharmacopoeia for injection items.

preparation example 3

[0032] Preparation Example 3 Preparation of formononetin-3'-sodium sulfonate freeze-dried powder injection

[0033] Take 50g of formononetin-3'-sulfonate, add 2000ml of water for injection after mixing, add 8g of mannitol, stir to dissolve, ultrafiltration to obtain a pyrogenic clear liquid, pour it into a 10ml vial, 2ml / piece, According to freeze-dried powder injection process, freeze-dried powder injections are made into freeze-dried powder injections each containing 50 mg.

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Abstract

The invention relates to the new usage of formononetin-3'-sodium sulfonate, and provides the application of the formononetin-3'-sodium sulfonate in the preparation of medicine for treating or preventing cardiovascular disease. The invention more particularly relates to the application of the formononetin-3'-sodium sulfonate in the preparation of medicine for treating or preventing coronary heart disease, angina pectoris or myocardial infarction. The formononetin-3'-sodium sulfonate remarkably reduces the rise of acute myocardial ischaemia rat limb lead electrocardiogram J point, and the ischemic area.

Description

Technical field [0001] The invention relates to a new use of formononetin-3'-sulfonic acid sodium, in particular to the application of formononetin-3′-sulfonate sodium in the preparation of medicines for treating or preventing cardiovascular diseases. Background technique [0002] Formononetin-3'-sodium sulfonate, the chemical name is 7-hydroxy-4'-methoxyisoflavone-3'-sodium sulfonate, and the chemical structure is shown below. CN101020684A provides a preparation method of formononetin-3'-sodium sulfonate, and its application for treating hyperlipidemia and fatty liver disease. However, there is no literature report on its application in the treatment of cardiovascular diseases. Through a large number of experimental studies, the present inventors provided the application of formononetin-3'-sulfonate in the preparation of drugs for the treatment or prevention of cardiovascular diseases. . [0003] Summary of the invention [0004] The invention provides the application of formon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P9/00A61P9/10
Inventor 蒋王林高玉白宋吉伦吴娟朱海波侯建田京伟孙丽芳孟莹
Owner SHANDONG GREENERY NATURAL MEDICINE RES & DEV
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