Rotundine crystal B-type solid matter and preparation method as well as applications

Abstract

The invention discloses a novel crystal-type state of rotundine solid chemical matter, which is shown as the formula (I), a preparation method of the novel crystal-type sample, and superior clinical therapeutic action of the novel crystal-type matter of the rotundine as active components in the preparation and the development of various formulations and medicament compositions for preventing and treating pains caused by various reasons, including headache, cramp, labour pains, and the like, and diseases caused by pains, such as insomnia, arrhythmia, and the like. Compared with the traditional officinal crystal-type solid matter (Crystal A type), the two types of novel crystal-type solid matter of the rotundine have higher absorption and blood concentration. Different crystal-type matter can influence the absorption speed and the blood concentration in an organism as well as the bioavailability of the active components of the medicaments, and thereby influencing the preventive and therapeutic effect of the medicaments in clinical applications.

Description

technical field The invention relates to a crystal B type substance of rotundine, which belongs to the technical field of medicine. Background technique Rotundine, chemical name is 2,3,9,10-tetramethoxy-5,8,13,13a-tetrahydro-6H-dibenzo[a,g]thiazine, specific rotation is -290 °~-300°, the structural formula is as follows: Luotong was designated as the second part of the 2005 edition of "Chinese Pharmacopoeia" [1] The drug category is recorded. At present, the drug includes rotundine tablet (page 339), rotundine hydrochloride tablet (page 536), and rotundine sulfate injection (page 339). Because rotundine drug itself has the defect of poor absorption, so just developed rotundine hydrochloride tablet, to promote its absorption. An article about “(-)-Tetrahydropalmatine Monohydrate” published in Acta Crystallographica Section C, Volume 54, Issue 12, Page 1977, was retrieved from the literature [2] , which records the crystal structure of Luotong fixed crystal type A, whi...

AI Technical Summary

Problems solved by technology

Due to the poor absorption of rotundine itself, rotundine hydrochloride tablets were developed to promote its absorption.

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