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Six-ingredient rehmannia soft capsules and preparation method thereof

A technology for yellow soft and capsule, applied in the field of Liuwei Dihuang soft capsule preparation and preparation thereof, can solve the problems of high dry paste rate, unfavorable molding, insufficient extraction or retention and the like

Active Publication Date: 2013-01-09
JIANGSU KANION PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] But the technology of the Liuwei Dihuang soft capsule of prior art is only limited to water extraction, alcohol extraction process, even without alcohol precipitation and other impurity removal processes, resulting in a higher dry paste rate, which is not conducive to molding, and the dosage is also large, which cannot meet the requirements of various conditions. The needs of patients by age group
At the same time, this process does not fully extract or retain the low-polarity components in Poria cocos and Alisma, such as triterpenic acids, iridoid glycosides and other modern studies that have pharmacological activities (lowering blood sugar and lipids)

Method used

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  • Six-ingredient rehmannia soft capsules and preparation method thereof
  • Six-ingredient rehmannia soft capsules and preparation method thereof
  • Six-ingredient rehmannia soft capsules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0175] 1. Prescription:

[0176] Rehmannia glutinosa 1440g Cornus officinalis (made) 720g Moutan bark 540g

[0177] Yam 720g Poria 540g Alisma 540g

[0178] Make 1000 capsules

[0179] 2. Preparation prescription:

[0180] Extract weight (accounting for 50%~60% of the molding preparation) 300~360g

[0181] Weight of soybean oil and beeswax (accounting for 50%~40% of the molding preparation) 300~240g

[0182] Made into 1000 refined Liuwei Dihuang soft capsules

[0183] 3. Preparation method:

[0184] For the above six flavors, take Rehmannia glutinosa and Cornus officinalis (manufactured) and add 8 times the amount of ethanol to soak for 1.5 hours, heat and reflux to extract for 2 hours, filter, and use the dregs for later use. The filtrate is concentrated under reduced pressure to a clear ointment with a relative density of 1.10. of water, stirred evenly, filtered, the filtrate was refrigerated for 12 hours, centrifug...

Embodiment 2

[0191] 1. Prescription:

[0192] Rehmannia glutinosa 1440g Cornus officinalis (made) 720g Moutan bark 540g

[0193] Yam 720g Poria 540g Alisma 540g

[0194] Make 1000 capsules

[0195] 2. Preparation prescription:

[0196] Extract weight (accounting for 50%~60% of the molding preparation) 300~360g

[0197] Weight of soybean oil or glycerin (accounting for 50%~40% of the molding preparation, 300~240g

[0198] Made into 1000 refined Liuwei Dihuang soft capsules

[0199] 3. Preparation method:

[0200] For the above six flavors, take Rehmannia glutinosa and Cornus officinalis (manufactured) and add 8 times the amount of ethanol to soak for 3 hours, heat and reflux to extract for 2 hours, filter, and use the dregs for later use; the filtrate is concentrated under reduced pressure to a clear paste, add appropriate amount of water to the clear paste, and stir evenly , filtered, the filtrate was refrigerated, centrifuged, ...

Embodiment 3

[0207] 1. Prescription:

[0208] Rehmannia glutinosa 1440g Cornus officinalis (made) 720g Moutan bark 540g

[0209] Yam 720g Poria 540g Alisma 540g

[0210] Make 1000 capsules

[0211] 2. Preparation prescription:

[0212] Extract weight (accounting for 50%~60% of the molding preparation) 300~360g

[0213] Soybean oil weight (accounting for 50%~40% of the molding preparation) 300~240g

[0214] Made into 1000 refined Liuwei Dihuang soft capsules

[0215] 3. Preparation method:

[0216] For the above six flavors, take Rehmannia glutinosa and Cornus officinalis (manufactured) and add 8 times the amount of ethanol to soak for 1.5 hours, heat and reflux to extract for 2 hours, filter, and use the dregs for later use. The filtrate is concentrated under reduced pressure to a clear ointment with a relative density of 1.10. of water, stirred evenly, filtered, the filtrate was refrigerated for 12 hours, centrifuged, the supernatant ...

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Abstract

The invention discloses six-ingredient rehmannia soft capsules and a preparation method thereof. When the preparation method provided by the invention is used, relatively more active ingredients of a medicament can be extracted, impurities are removed, and medicinal effects are better played, so that the dosage of the medicament is reduced.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a Liuwei Dihuang soft capsule preparation and a preparation method thereof. technical background [0002] Liuwei Dihuang Pills, whose prescription comes from the "Children's Medicine and Syndrome Straight Jue" by Qian Yi, a medical scientist in the Song Dynasty, is a basic prescription for nourishing kidney yin, and is also a famous prescription for tonifying kidney. Liuwei Dihuang Wan is composed of six traditional Chinese medicines: Rehmannia glutinosa, Cornus officinalis, Chinese yam, Alisma, paeonol and Poria. The earliest is "Bawei Dihuang Wan", found in Zhang Zhongjing's "Synopsis of the Golden Chamber". Later, Qian Yi, a famous doctor and pediatrician in the Song Dynasty, removed the warming and tonifying medicines such as aconite and cinnamon twigs in Bawei Dihuang Wan, and turned it into the current Liuwei Dihuang Wan. [0003] On the basis of L...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8945A61K9/48A61P1/14A61P13/12
Inventor 萧伟王振中刘涛徐玉玲李淼尚强章晨峰陈凤龙
Owner JIANGSU KANION PHARMA CO LTD
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