Method for resolving alpha-substituted-2-amino acetamide

Abstract

The invention relates to a process for efficiently resolving alpha-substitued-2-amino acetamide (structural formula I), multiple (+) or (-) alpha-substitued-2-amino acetamide are important intermediate for preparing medicine and pesticide. The resolving process of the invention includes asymmetric transformation of diastereoisomer, thus realizing a new high efficiency dynamic resolving method. In the structural formula I, R is alkyl (C1-C5), randomly substituted alcohol, aldehyde, acid and derivate thereof (C1-C5), benzene and randomly substituted benzene.

Description

technical field The present invention relates to a high-yield resolution process for α-substituted-2-aminoacetamides. A variety of (+) or (-) α-substituted-2-aminoacetamides are important intermediates for the preparation of medicines and pesticides body. Structural Formula I Here, R=hydrocarbyl (C1-C5), optionally substituted alcohol, aldehyde, acid and its derivatives (C1-C5), benzene, optionally substituted benzene. Background technique Many of the many α-substituted-2-aminoacetamides are amide derivatives of natural amino acids. For example: Amide derivatives of alanine Amide derivatives of asparagine Amide derivatives of aspartic acid Amide derivatives of cysteine Amide derivatives of glutamic acid Amide derivatives of isoleucine Amide Derivatives of Leucine Amide Derivatives of Valine etc, Amide derivatives of these amino acids have gradually become pharmaceutical intermediates. At present, the most frequently used amide derivatives of severa...

AI Technical Summary

Problems solved by technology

In the patent GB837216, the resolution of L-valylamide is also mentioned, and there is also the same problem as S-(+)-α-ethyl-2-aminoacetamide

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