Preparation method of malan straw extract, malan straw product, pharmaceutical composition and application thereof

An extract, the technology of Malancao, applied in the field of preparation of Malancao extract, can solve the problems that the pharmacological research of Malancao extract has not been reported yet

Inactive Publication Date: 2011-02-02
GUIZHOU NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there is no report on the

Method used

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  • Preparation method of malan straw extract, malan straw product, pharmaceutical composition and application thereof
  • Preparation method of malan straw extract, malan straw product, pharmaceutical composition and application thereof
  • Preparation method of malan straw extract, malan straw product, pharmaceutical composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] Embodiment 1 of the present invention: preparation of Malancao water extract

[0093] Take 10kg of dried Malancao whole grass, crush it into medium powder, add 8 times the amount of water to decoct twice for 1 hour each time, filter, combine the filtrate, concentrate to 60°C and measure the relative density to 1.30, let it cool, and add ethanol Make the alcohol content to 70%, let it stand overnight, take the supernatant and concentrate under reduced pressure to a thick paste with a relative density of 1.25, and dry under reduced pressure at 75° C. to obtain 290 g of Malancao water extract.

Embodiment 2

[0094] Embodiment 2 of the present invention: the preparation of Malancao ethanol extract:

[0095] Take 10kg of dried Malan grass whole grass, grind it into medium powder, add 8 times the amount of 60% ethanol to reflux and extract twice, each time for 1 hour, filter, combine the filtrates, recover ethanol under reduced pressure, and concentrate the remaining liquid to a relative density of 1.25 thick paste, dried under reduced pressure to obtain 450 g of Malancao ethanol extract.

Embodiment 3

[0096] Embodiment 3 of the present invention: the preparation of Malancao petroleum ether extract:

[0097] After pulverizing 10 kg of dried Malancao whole grass, heat and reflux with petroleum ether to extract, use 40L petroleum ether each time, extract 3 times, each time for 1.5 hours, filter, combine the filtrates, evaporate to dryness under reduced pressure, and obtain petroleum ether extract Material 310g.

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PUM

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Abstract

The invention provides a preparation method of a malan straw extract, a malan straw product, a pharmaceutical composition and an application thereof. The preparation method comprises the following steps: selecting a right amount of malan straw, crushing into coarse powder or intermediate powder, extracting 2-3 times by decoction in water or by ethanol/petroleum ether refluxing with 1-2 hours for each time, filtering, merging the filtrates, concentrating, and drying to obtain the malan straw extract. The preparation process of the malan straw extract is simple and practicable, and the obtained extract has obvious anti-inflammatory effect and pain-relieving effect and shows good effects for treating hepatitis, gynecologic inflammation, inflammation of urinary system, pneumonia and nephritis diseases, thereby achieving favorable application prospects.

Description

technical field [0001] The invention relates to a preparation method of Malancao extract and its product, pharmaceutical composition and application, and belongs to the technical field of traditional Chinese medicine extraction. Background technique [0002] Malancao is the dry whole herb of the Compositae plant (Kalimeris indica (L.) Sch.-Bip.), which is harvested in summer and autumn. It is a unique and commonly used medicine in Southwest China and has a long history of medicinal use. Malan herb was recorded in the 2003 edition of "Quality Standards of Traditional Chinese Medicinal Materials and Ethnic Medicinal Materials in Guizhou Province". According to the book, Malan grass has the functions of regulating qi and eliminating food, clearing away heat and dampness, detoxifying and reducing swelling, and is used for stomach pain, jaundice, and cold Cough, sore throat, traumatic bleeding, edema, stranguria, hemorrhoids. Malancao can be used alone or in combination. In the...

Claims

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Application Information

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IPC IPC(8): A61P15/00A61P13/12A61K36/28A61P29/00A61P1/16A61P13/00A61P11/00
Inventor 周欣陈华国龚小见赵超
Owner GUIZHOU NORMAL UNIVERSITY
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