Thermorod for active drug release and method for manufacturing the same

Abstract

Disclosed is a thermorod for active drug release capable of actively releasing drugs according to temperature and a method of manufacturing the same. The method for manufacturing a thermorod that generates heat by means of eddy current loss and hysteresis loss in an induced magnetic field comprises: processing the thermorod into a certain shape; preparing a mixed- drug specimen by mixing a drug with a high molecular compound acting as a support of the drug; and forming a mixed-drug layer on the surface of the thermorod by using the mixed-drug specimen. Therefore, the method and the thermorod prepared thereby may be useful to effectively perform the drug administration and anti-cancer drug treatment of affected parts since they may be used to perform local hyperthermia at 36.5 DEG C or above and to actively control the active drug release and delivery according to temperature as well. Also, the method and the thermorod prepared thereby may be useful in the treatment of resting tumor cells along with hyperthermia by performing a surgical operation on lesion sites of biological tissues using the thermorod, and in minimizing the toxicity caused by an increase in blood drug concentration, which is generated when a drug is administered by a conventional method, since the drug is effectively delivered to an affected part in response to the active drug release.

Description

technical field [0001] The invention relates to a drug-releasing thermoelectric rod for actively releasing drugs according to temperature and a manufacturing method thereof, especially to form a drug-mixed layer or a drug-mixed layer and a coating on the surface of a thermoelectric rod to actively release drugs at a certain temperature and at a certain concentration. A drug-releasing thermoelectric rod and method of manufacturing the same. Background technique [0002] Anticancer chemotherapy for tumor treatment generally uses Paclitaxel. Anticancer treatment using paclitaxel, usually 135-175 mg / m three times a week 2 The volume of medicine is injected into the body by intravenous injection over a period of more than three hours. The number of treatments should be repeated more than 4 to 6 times (more than 6 months of treatment). Paclitaxel injected into the body reaches the affected area through complex physiological processes and obtains curative effect. [0003] In th...

AI Technical Summary

Problems solved by technology

[0006] Radioisotope implantation is the treatment of tumors by inserting implants made of Iodine-125 or Palladium-103 into the tissue, but the proper dose needed to eliminate the cancer is not known

High-dose brachytherapy utilizes the Iridium-192 implant, but there are technical problems with removing the radioactive implant from the urinary catheter

[0007] Cryotherapy is to insert a 6- to 8-inch tube into the prostate through the rectum, and use the tube to circulate frozen liquid nitrogen. It has the advantages of simple process and few complications. Insert a urinary catheter

Images