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Helichrysum arenarium Moench extractive as well as preparation method and application thereof

A technology of Helichrysum spp

Active Publication Date: 2012-11-21
HARBIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] So far, there are no literature and historical records about the blood lipid-lowering and anti-atherosclerotic effects of the traditional Chinese medicine Helichrysum chrysanthemum and its total extracts

Method used

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  • Helichrysum arenarium Moench extractive as well as preparation method and application thereof
  • Helichrysum arenarium Moench extractive as well as preparation method and application thereof
  • Helichrysum arenarium Moench extractive as well as preparation method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0017] The preparation of embodiment 1 Helichrysum chrysanthemum flower extract

[0018] Helichrysum chrysanthemum dried flowers were heated and extracted with 75% ethanol under reflux to obtain ethanol extract (ie: total extract of Helichrysum chrysanthemum flowers), and the ethanol extract was extracted and degreased with ethyl acetate to obtain ethyl acetate extracts respectively and the water layer part; the water layer part was eluted with water and 90% ethanol with a volume fraction of 90% ethanol through HP-20 macroporous adsorption resin, respectively, to obtain 90% ethanol eluate.

Embodiment 2

[0019] The preparation of embodiment 2 Helichrysum chrysanthemum flower extract

[0020] Helichrysum chrysanthemum dried flowers were heated and extracted with 30% ethanol under reflux to obtain ethanol extract (ie: total extract of Helichrysum chrysanthemum flowers), and the ethanol extract was extracted and degreased with ethyl acetate to obtain ethyl acetate extracts respectively and the water layer part; the water layer part was eluted with water and 90% ethanol with a volume fraction of 90% ethanol through HP-20 macroporous adsorption resin, respectively, to obtain 90% ethanol eluate.

Embodiment 3

[0021] The preparation of embodiment 3 Helichrysum japonicus flower extract

[0022] Extract the dried Helichrysum chrysanthemum flower with 50% ethanol under reflux to obtain the ethanol extract (ie: the total extract of Helichrysum chrysanthemum flower), extract and degrease the ethanol extract with ethyl acetate, and obtain the ethyl acetate extract respectively and the water layer part; the water layer part was eluted with water and 90% ethanol with a volume fraction of 90% ethanol through HP-20 macroporous adsorption resin, respectively, to obtain 90% ethanol eluate.

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Abstract

The invention discloses a Helichrysum arenarium Moench extractive as well as a preparation method and an application thereof. By a great quantity of animal experiments, the invention finds that the Helichrysum arenarium Moench extractive can effectively lower neutral fat content in animal hepatocyte, can obviously lower the content of total cholesterol and triglyceride in high blood fat rat bloodand has the efficacy on effectively lowering blood fat. In addition, the Helichrysum arenarium Moench has the action on resisting atherosclerosis. The pharmacodynamics experiment shows that the Helichrysum arenarium Moench extractive can be used for the adjuvant therapy of obesity, high blood fat, atherosclerosis and relevant complications. The Helichrysum arenarium Moench extractive of the invention is characterized in that alcohols for Helichrysum arenarium Moench are heated and reflowed to extract and obtain an alcohol extractive; and after various auxiliary materials required by preparingdifferent dosage forms and pharmaceutically acceptable carriers are added, the mixture is prepared into any one suitable clinic preparation with a conventional Chinese material medical preparation method.

Description

technical field [0001] The present invention relates to a traditional Chinese medicine extract, in particular to an extract of Helichrysum chrysanthemum flower and its preparation method. The present invention also relates to the use of the extract of Helichrysum chrysanthemum flower in obesity, hyperlipidemia, atherosclerosis and related complications The application in the adjuvant therapy of the present invention belongs to the field of medical application of the extract of Helichrysum chrysanthemum flower. Background technique [0002] Hyperlipidemia refers to a disease caused by the concentration of lipids in plasma, especially total cholesterol and triglycerides, exceeding the normal range. Elevated blood lipids are mainly due to excessive accumulation of fat, cholesterol and other substances in the body caused by improper diet, attenuation of visceral qi, and liver and kidney yin deficiency, which can lead to fatty liver, cirrhosis, cholelithiasis, peripheral vascular...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/28A61P3/04A61P3/06A61P9/10A61K133/00
Inventor 王立波杨宝峰侯云龙吴立军朱久新
Owner HARBIN MEDICAL UNIVERSITY