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Compound medicine containing antihypertensive peptide and aldosterone receptor antagonist for curing hypertension

A receptor antagonist, aldosterone technology, applied in the field of compound pharmaceutical composition, can solve the problem of limited effect

Active Publication Date: 2013-07-03
TIANJIN JINYAO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, due to the limited effect of hypotensive peptides in reducing blood pressure, they are generally used as food additives

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-1

[0038] active ingredient

[0039] Spironolactone (particle size 5-20μm) 5.0g

[0040] IPP 100.0g

[0041] Accessories:

[0042] 100g pregelatinized starch

[0043] Microcrystalline Cellulose 100g

[0044] Lactose 180g

[0045] Carboxymethyl Starch Sodium 4g

[0046] Micronized silica gel 5g

[0047] Magnesium Stearate 3g

[0048] Proper amount of povidone aqueous solution

[0049] A total of 1000 pieces were made

[0050] Weigh the active ingredient, pregelatinized starch, microcrystalline cellulose, and lactose according to the prescription amount, pass through a 60-100 mesh sieve respectively, after mixing evenly, add an appropriate amount of povidone aqueous solution to make a soft material, 20 mesh sieve to make granules, and dry. Whole granules, add magnesium stearate, sodium starch glycolate, micropowder silica gel, mix well and press into tablets with a suitable die.

Embodiment 1-2

[0052] active ingredient

[0053] Spironolactone (particle size 5-20μm) 50.0g

[0054] IPP 200.0g

[0055] Accessories:

[0056] 100g pregelatinized starch

[0057] Microcrystalline Cellulose 120g

[0058] Lactose 230g

[0059] Carboxymethyl Starch Sodium 4g

[0060] Micronized silica gel 5g

[0061] Magnesium Stearate 3g

[0062] Proper amount of povidone aqueous solution

[0063] A total of 1000 pieces were made

[0064] Weigh the active ingredient, pregelatinized starch, microcrystalline cellulose, and lactose according to the prescription amount, pass through a 60-100 mesh sieve respectively, after mixing evenly, add an appropriate amount of povidone aqueous solution to make a soft material, 20 mesh sieve to make granules, and dry. Whole granules, add magnesium stearate, sodium starch glycolate, micropowder silica gel, mix well and press into tablets with a suitable die.

Embodiment 1-3

[0066] active ingredient

[0067] Spironolactone (particle size 5-20μm) 100.0g

[0068] IPP 100.0g

[0069] Accessories:

[0070] 120g pregelatinized starch

[0071] Microcrystalline Cellulose 160g

[0072] Lactose 200g

[0073] Carboxymethyl Starch Sodium 4g

[0074] Micronized silica gel 5g

[0075] Magnesium Stearate 3g

[0076] Proper amount of povidone aqueous solution

[0077] A total of 1000 pieces were made

[0078] Weigh the active ingredient, pregelatinized starch, microcrystalline cellulose, and lactose according to the prescription amount, pass through a 60-100 mesh sieve respectively, after mixing evenly, add an appropriate amount of povidone aqueous solution to make a soft material, 20 mesh sieve to make granules, and dry. Whole granules, add magnesium stearate, sodium starch glycolate, micropowder silica gel, mix well and press into tablets with a suitable die.

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Abstract

The invention provides a compound medicine containing antihypertensive peptide and aldosterone receptor antagonist for curing hypertension, which is composed of aldosterone receptor antagonist as an active component, peptide for reducing blood pressure and one or more pharmaceutic adjuvants, wherein the peptide for reducing blood pressure is peptide which has angiotensin converting enzyme inhibition.

Description

Technical field: [0001] The present invention relates to a compound pharmaceutical composition for the treatment of hypertension, which is composed of the active ingredient aldosterone receptor antagonist (SARA), a peptide capable of lowering blood pressure, and one or more excipients that can be used in medicine, especially the composition Oral preparations can be made. Background technique: [0002] Blood pressure refers to the pressure that blood exerts on the walls of blood vessels when it flows in a person's blood vessels. Hypertension refers to the increase of systemic arterial blood pressure, which is a common clinical syndrome. It can also be said that it is a systemic disease characterized by increased systolic and diastolic blood pressure, often accompanied by heart, brain, kidney and other organ functions or organic changes. It can be caused by a variety of pathogenic factors and complex pathogenesis. Central nervous system dysfunction, humoral endocrine inherita...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/06A61K38/05A61K38/06A61K38/08A61P9/12
Inventor 孙亮陈松赵琳
Owner TIANJIN JINYAO GRP
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