Transmission device

Abstract

The invention discloses a transmission device which is used for transmitting a substance to a target in a physical mode. The transmission device comprises an input module, a transmission module and an output module, wherein the input module is used for transmitting load carrying fluid; the transmission module is connected with the input module, internally stored with the substance and used for receiving the load carrying fluid to atomize the substance and mix the load carrying fluid with the substance; the output module is provided with a first opening and a second opening, and the caliber ofthe first opening is larger than that of the second opening; and the mixture of the substance and the load carrying fluid enters the output module through the first opening and is output from the output module through the second opening.

Description

technical field [0001] The present invention relates to a delivery device, which can physically deliver substances into cells. Background technique [0002] There are many methods of transdermal drug delivery, including the use of physical principles, mechanical principles, or a combination of the two. For example, the more common methods of transdermal drug delivery include electroporation, microinjection, etc., the purpose of which is to It is to directly introduce the drug into the surface layer of the skin. However, the stability and success rate of these physical drug delivery methods are relatively low at present, and the operation is quite difficult, so they cannot be widely used. In recent years, research on gene guns has become the main trend of physical gene transfer technology. The reason is that gene guns can overcome the predicament that other methods cannot effectively carry substances to cells, thus making the clinical application of gene transfer technology a...

AI Technical Summary

Problems solved by technology

Although this type of gene gun can overcome the bottleneck encountered by conventional gene guns, because the conventional gene gun flows in a turbulent manner before the sample enters its nozzle, the sample is easily damaged due to collision with the tube wall. Condensation on its surface, and because the design of the nozzle itself has a dead angle, and the kinetic energy provided by the low-pressure gas is low, it cannot effectively bring out the sample remaining on the tube wall, so it is accelerated for the conventional low-pressure gas As far as the gene gun is concerned, its biggest disadvantage is that the liquid is easy to remain in the wall of the nozzle tube, which makes quantitative and continuous operation impossible.

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