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Carbon nano tube/polymer/magnetic ferrate nano composite material and preparation method thereof

A technology of nanocomposite materials and carbon nanotubes, which is applied in the direction of nuclear magnetic resonance/magnetic resonance imaging contrast agents, etc., to achieve the effect of simple operation, low cost and integrity protection

Inactive Publication Date: 2013-11-27
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few reports on the preparation of magnetic resonance contrast agents by modifying magnetic nanoparticles on carbon nanotubes.

Method used

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  • Carbon nano tube/polymer/magnetic ferrate nano composite material and preparation method thereof
  • Carbon nano tube/polymer/magnetic ferrate nano composite material and preparation method thereof
  • Carbon nano tube/polymer/magnetic ferrate nano composite material and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0030] 1) 30 mg chitosan was dissolved in 30 mL of dilute acetic acid solution (the mass fraction of acetic acid was 2%) to obtain solution a;

[0031] 2) adding 30 mg of multi-walled carbon nanotubes to the above-mentioned solution a, and ultrasonicating for 1 hour to obtain solution b;

[0032] 3) Slowly add dilute ammonia water to the b solution obtained in step 2) until the pH of the solution is about 7, then add 20 mL of a 15% glutaraldehyde solution dropwise, stir magnetically at room temperature for 24 hours, centrifuge at 12,000 rpm, remove the upper Clear liquid, the obtained carbon nanotube / chitosan composite was washed 5 times with distilled water;

[0033] 4) Disperse the carbon nanotube / chitosan composite obtained above in 50mL distilled water, sonicate for 1h, and add 0.3mmol FeCl to it 3 ·6H 2 O and 0.15 mmol FeCl 2 4H 2 O, stirred for 30min to make Fe 3+ and Fe 2+ Fully coordinate with the O atoms in chitosan to modify the carbon nanotubes to obtain solut...

Embodiment 2

[0041] 1) 30 mg chitosan was dissolved in 30 mL of dilute acetic acid solution (the mass fraction of acetic acid was 2%) to obtain solution a;

[0042] 2) adding 30 mg of multi-walled carbon nanotubes to the above-mentioned solution a, and ultrasonicating for 1 hour to obtain solution b;

[0043] 3) Slowly add dilute ammonia water to the b solution obtained in step 2) until the pH of the solution is about 7, then add 20 mL of a 15% glutaraldehyde solution dropwise, and then magnetically stir for 24 hours at room temperature, then centrifuge at 12000 rpm, The supernatant was removed, and the carbon nanotube / chitosan composite obtained was washed 5 times with distilled water;

[0044] 4) Disperse the carbon nanotube / chitosan composite obtained above in 50mL distilled water, sonicate for 1h, and add 0.3mmol FeCl to it 3 ·6H 2 O and 0.15 mmol of CoCl 2 ·6H 2 O, stirred for 30min to make Fe 3+ and Fe 2+ Fully coordinate with the O atoms in chitosan to modify the carbon nanotu...

Embodiment 3

[0052] A) 30mg chitosan is dissolved in the dilute acetic acid solution of 30mL (the mass fraction of acetic acid is 2%);

[0053] b) adding 30 mg of multi-walled carbon nanotubes to the above solution, and ultrasonicating for 1 hour to obtain solution b;

[0054] c) Slowly add dilute ammonia water to the solution b until the pH of the solution is about 7, then add 20 mL of 15% glutaraldehyde solution dropwise, and then magnetically stir for 24 hours at room temperature, then centrifuge to obtain carbon nanotubes / Chitosan complex, this complex is washed 5 times with distilled water, 12000rpm centrifugal 10min;

[0055] d) Disperse the carbon nanotube / chitosan composite obtained above in 50mL distilled water, sonicate for 1h, and add 0.3mmol FeCl to it 3 ·6H 2 O and 0.15 mmol of CoCl 2 ·6H 2 O, stirred for 30min to make Fe 3+ and Fe 2+ Fully coordinate with the O atoms in chitosan to modify the carbon nanotubes to obtain solution d;

[0056] e) Add 1mol / L NaOH solution ...

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Abstract

The invention discloses a carbon nano tube / polymer / magnetic ferrate nano composite material which is formed by sequentially coating polymers and magnetic ferrate nano particles on carbon nano tubes from inside to outside, wherein the carbon nano tubes are multi-wall carbon nano tubes (MWCNTs), the polymers are chitosan, and the magnetic ferrate nano particles are Fe3O4 or CoFe2O4; and the chitosan as the polymers is firstly coated on the MWCNTs, and then Fe3+ and Fe2+ (or Co2+) are adsorbed on the MWCNTs, thereby the magnetic ferrate nano particles are generated in a coprecipitation method. The carbon nano tube are not processed by acid so that the structural integrity of the carbon nano tubes is protected; the modified carbon nano tubes have magnetism; the chitosan has favorable biocompatibility and is beneficial to the biological application of the material, and the obtained nano composite material is expected to be used as a magnetic resonance contract medium; and the carbon nano tube / polymer / magnetic ferrate nano composite material has the advantages of simple operation, easy obtainment of raw materials and low cost.

Description

technical field [0001] The invention relates to a carbon nanotube / polymer / magnetic ferrite nanocomposite material and a preparation method thereof, belonging to the technical field of nanocomposite materials. Background technique [0002] Carbon nanotubes have been a research hotspot at home and abroad because of their excellent mechanical, thermal and electrical properties. In recent years, the application of magnetic nanoparticles in carrying drugs and magnetic resonance contrast agents has become a research hotspot. Among these applications, the problems of water solubility and biocompatibility of nanoparticles are mainly to be solved. In order to solve these problems, people wrap some macromolecules such as PEG on the surface of nanoparticles, or use SiO 2 Come to the package and get some grades. Carbon nanotubes have good biocompatibility, and they are excellent carriers of nanoparticles. However, there are few reports on the preparation of magnetic resonance contra...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/06
Inventor 吴惠霞刘刚张豪强杨仕平
Owner SHANGHAI NORMAL UNIVERSITY
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