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Application of Fasudil in preparing drug for treating pulmonary hypertension by atomized inhalation

A technology of pulmonary arterial hypertension and fasudil, applied in the field of medicine, can solve problems such as adverse reactions, achieve good stability, long duration of curative effect, and quick effect

Inactive Publication Date: 2011-04-13
TIANJIN CHASE SUN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] In recent years, there have also been literature reports on the treatment of pulmonary hypertension with fasudil injection, but there are adverse reactions caused by fasudil injection on the circulatory system, blood system, liver function, urinary system, digestive system and other allergic reactions.

Method used

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  • Application of Fasudil in preparing drug for treating pulmonary hypertension by atomized inhalation
  • Application of Fasudil in preparing drug for treating pulmonary hypertension by atomized inhalation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] spray solution

[0032] Prescription (1000 sticks)

[0033] Fasudil Hydrochloride 10.0g

[0034] Sodium chloride 50.0g

[0035] Vitamin E 0.5g

[0036] Citric acid amount

[0037] Add purified water to 5000ml

[0038] Made 1000 pieces

[0039] Preparation Process

[0040] Weigh fasudil hydrochloride in an appropriate amount of distilled water, stir and heat to dissolve; take another amount of sodium chloride, vitamin E, and citric acid to dissolve in an appropriate amount of boiled distilled water, stir to dissolve; combine the two liquids, shake well, Dilute it with purified water to the prepared amount, pack it separately, and obtain it.

Embodiment 2

[0042] Application of fasudil prepared by nebulization inhalation for the treatment of pulmonary arterial hypertension

[0043] Instruments and reagents The air compressor pump produced by Germany Berry Company was used as the atomization generator, and Fasudil spray was used. Collagen I, III polyclonal antibody, Sp kit.

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Abstract

The invention belongs to the technical field of medicine, particularly relating to an application of Fasudil in preparing a drug for treating pulmonary hypertension by atomized inhalation. The Fasudil comprises the modes of pharmaceutically acceptable salts, such as hydrochloride, nitrate, sulphate, phosphate, hydrobromide, mesylate, citrate and the like of the Fasudil, and comprises the pharmaceutically acceptable modes, such as a crystallization mode, a hydrate mode and the like of the Fasudil. The drug is a drug preparation composition prepared by taking the Fasudil as the drug active ingredient.

Description

technical field [0001] The invention belongs to the technical field of medicine, and particularly relates to the application of fasudil in the preparation of medicines for treating pulmonary arterial hypertension through nebulization and inhalation administration. Background technique [0002] Pulmonary hypertension refers to those whose mean pulmonary arterial pressure is >3.33kPa (25mmHg) at rest or >4kPa (30mmHg) during exercise. Since the pulmonary vascular resistance is the ratio of the difference between the mean pulmonary artery pressure and the mean pulmonary venous pressure to the pulmonary blood flow, that is, the mean pulmonary arterial pressure is the sum of the mean pulmonary venous pressure plus the product of the pulmonary vascular resistance and the pulmonary blood flow. Factors that increase flow and pulmonary vascular resistance can cause pulmonary hypertension. Pulmonary hypertension is an extremely malignant disease and is the cancer among cardiova...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/551A61K9/08A61K9/12A61P11/00A61P9/12
Inventor 姚小青孙长海董凯王瑞卿
Owner TIANJIN CHASE SUN PHARM CO LTD
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