Application of Fasudil in preparing drug for treating pulmonary hypertension by atomized inhalation

A technology of pulmonary arterial hypertension and fasudil, applied in the field of medicine, can solve problems such as adverse reactions, achieve good stability, long duration of curative effect, and quick effect
CN102008487AInactive Publication Date: 2011-04-13TIANJIN CHASE SUN PHARM CO LTD
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
TIANJIN CHASE SUN PHARM CO LTD
Publication Date
2011-04-13
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention belongs to the technical field of medicine, particularly relating to an application of Fasudil in preparing a drug for treating pulmonary hypertension by atomized inhalation. The Fasudil comprises the modes of pharmaceutically acceptable salts, such as hydrochloride, nitrate, sulphate, phosphate, hydrobromide, mesylate, citrate and the like of the Fasudil, and comprises the pharmaceutically acceptable modes, such as a crystallization mode, a hydrate mode and the like of the Fasudil. The drug is a drug preparation composition prepared by taking the Fasudil as the drug active ingredient.
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Description

technical field

[0001] The invention belongs to the technical field of medicine, and particularly relates to the application of fasudil in the preparation of medicines for treating pulmonary arterial hypertension through nebulization and inhalation administration. Background technique

[0002] Pulmonary hypertension refers to those whose mean pulmonary arterial pressure is >3.33kPa (25mmHg) at rest or >4kPa (30mmHg) during exercise. Since the pulmonary vascular resistance is the ratio of the difference between the mean pulmonary artery pressure and the mean pulmonary venous pressure to the pulmonary blood flow, that is, the mean pulmonary arterial pressure is the sum of the mean pulmonary venous pressure plus the product of the pulmonary vascular resistance and the pulmonary blood flow. Factors that increase flow and pulmonary vascular resistance can cause pulmonary hypertension. Pulmonary hypertension is an extremely malignant disease and is the cancer among cardiova...

Claims

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