Methods, systems, compositions and dosage forms for diagnosing and treating male infertility

A composition, possible technology, applied in the field of diagnosis and treatment of male infertility, able to solve problems such as unsuccessful IVF cycles
CN102014938AInactive Publication Date: 2011-04-13PEERION MEDICAL TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
PEERION MEDICAL TECH
Publication Date
2011-04-13
Estimated Expiration
Not applicable · inactive patent

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Abstract

Methods and systems are provided for diagnosing male infertility relating to inadequate production of phosphatidic acid and are complementary to the routine tests, assessing sperm count, motility, viability, head morphology, and white blood cell count. Additional therapeutic methods, compositions and dosage forms are provided for treating male infertility that is related to inadequate production of phosphatidic acid. Such therapeutic approaches involve the use of phosphatidic acid or at least one of its precursors in the sperm intracellular signaling pathway.
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Description

technical field

[0001] The present invention relates to methods, systems, compositions and dosage forms for the diagnosis and treatment of male infertility. Background technique

[0002] In order to fertilize eggs, mammalian sperm usually need to stay in the female reproductive tract for several hours. During this period, sperm undergo a series of biochemical changes, collectively referred to as "capacitation", that is, to obtain the ability to fertilize. Only fertilizing sperm can undergo the acrosome reaction after binding to the zona pellucida, a process that enables the sperm to penetrate the egg and fertilize it. During capacitation, polymerization of globular actin (G-actin) to filamentous actin (F-actin) occurs according to protein kinase A activation, protein tyrosine phosphorylation, and phospholipase D activation. Filamentous actin formation is important for the translocation of phospholipase C from the cytoplasm to the sperm plasma membrane during capacitation ...

Claims

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