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Methods, systems, compositions and dosage forms for diagnosing and treating male infertility

A composition, possible technology, applied in the field of diagnosis and treatment of male infertility, able to solve problems such as unsuccessful IVF cycles

Inactive Publication Date: 2011-04-13
PEERION MEDICAL TECH
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Problems solved by technology

[0017] The indications of ICSI include but not limited to: (1) sperm concentration 6 / cm 3 , (2) Sperm motility <5%, (3) Sperm morphology normal to strict criteria <4%, (4) Sperm can only be obtained surgically, and (5) Previous IVF cycle was unsuccessful

Method used

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  • Methods, systems, compositions and dosage forms for diagnosing and treating male infertility
  • Methods, systems, compositions and dosage forms for diagnosing and treating male infertility
  • Methods, systems, compositions and dosage forms for diagnosing and treating male infertility

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Embodiment

[0099] The following clinical trials were used to evaluate sperm capacitation and are disclosed herein as exemplary embodiments of the present invention.

[0100] The attached table describes the results of the clinical trial conducted at the Fertility Clinic with 36 male subjects participating in the trial. A semen sample was obtained from each subject and divided into two equal portions.

[0101] The subjects were divided into 3 groups: (1) low acrosome reaction (low AR) group, in which 0.9-9% of sperm cells underwent AR; (2) moderate acrosome reaction (moderate AR) group, in which 10-19 % of sperm cells experience AR; 3) High acrosome reaction (high AR) group, in which 20-40% of sperm cells experience AR.

[0102] One purpose of the above clinical trials is to examine AR process and The amount of filamentous actin increases by more than 10% possible connection between the two. Under similar nominal physiological conditions, for each subject, the percentage of cells un...

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Abstract

Methods and systems are provided for diagnosing male infertility relating to inadequate production of phosphatidic acid and are complementary to the routine tests, assessing sperm count, motility, viability, head morphology, and white blood cell count. Additional therapeutic methods, compositions and dosage forms are provided for treating male infertility that is related to inadequate production of phosphatidic acid. Such therapeutic approaches involve the use of phosphatidic acid or at least one of its precursors in the sperm intracellular signaling pathway.

Description

technical field [0001] The present invention relates to methods, systems, compositions and dosage forms for the diagnosis and treatment of male infertility. Background technique [0002] In order to fertilize eggs, mammalian sperm usually need to stay in the female reproductive tract for several hours. During this period, sperm undergo a series of biochemical changes, collectively referred to as "capacitation", that is, to obtain the ability to fertilize. Only fertilizing sperm can undergo the acrosome reaction after binding to the zona pellucida, a process that enables the sperm to penetrate the egg and fertilize it. During capacitation, polymerization of globular actin (G-actin) to filamentous actin (F-actin) occurs according to protein kinase A activation, protein tyrosine phosphorylation, and phospholipase D activation. Filamentous actin formation is important for the translocation of phospholipase C from the cytoplasm to the sperm plasma membrane during capacitation ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/52A61K35/54
CPCG01N33/689G01N2333/4712G01N33/56966G01N2800/367A61P15/08
Inventor 哈伊姆·布莱特巴特
Owner PEERION MEDICAL TECH
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