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Expansible biocompatible coats comprising a biologically active substance

A bioactive substance, biocompatible technology, applied in the field of manufacturing said expandable hollow parts, can solve problems such as harmful side effects

Inactive Publication Date: 2011-04-13
AVIDAL VASCULAR
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a result, large quantities of the drug will not reach the diseased tissue but will be flooded and transported into downstream blood vessels and organs, which will lead to significant exposure of these tissues to cytostatic substances, leading to harmful side effects

Method used

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  • Expansible biocompatible coats comprising a biologically active substance
  • Expansible biocompatible coats comprising a biologically active substance
  • Expansible biocompatible coats comprising a biologically active substance

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0142] Experimental data indicate that short-term administration of paclitaxel to human endothelial progenitor cells (EPCs) and smooth muscle cells (SCMs) leads to apoptosis, thus inhibiting cell proliferation and migration. This effect was dose- and time-dependent; increasing the paclitaxel concentration and prolonging the administration time more inhibited cell proliferation and migration. Indicates that the expandable hollow part contains more than 6 μg / mm in its non-expanded state 2 paclitaxel.

[0143] It has been confirmed in animal experiments to use containing 1-6μg / mm 2 The expansible hollow part for the delivery of paclitaxel is more effective.

[0144] Accordingly, the most preferred application of the present invention is a paclitaxel-eluting expandable hollow member mounted on a balloon catheter for the treatment of stenosis or restenosis. Another most preferred application is a metallic stent mounted on a paclitaxel eluting expandable hollow member mounted on ...

Embodiment 2

[0146] A tubular expandable hollow part according to the invention made of polyisoprene was expanded by a factor of 1.25 using an expansion device. Crescent-shaped microcavities with an average length of about 300 μm were cut on the surface of the expandable hollow part using a titanium:sapphire laser. The laser settings are as follows: pulse duration: 150 fs; wavelength: 800 nm; spot size about 30 μm; pulse energy 3 μJ.

Embodiment 3

[0148] A tubular expandable hollow part with crescent-shaped microcavities made of polyisoprene as described in Example 2 was expanded by a factor of 2.5 using an expansion device. The hollow part is then placed in an ultrasonic spray system that uses high-frequency sound waves to create a fine liquid mist.

[0149] The operating vibration frequency of the nozzle was set at 120 kHz to produce a median droplet diameter of less than 20 μm from ethanol solutions of tripidil at a concentration of 250 mg / ml.

[0150] The expandable hollow part mounted on the expansion tool is placed under the nozzle and the spray gas is passed longitudinally at a speed of 1 mm / s while rotating constantly at 60 rpm.

[0151] After three consecutive runs, the coating of the hollow parts was examined using an optical microscope. More than 95% of the crescent-shaped microcavities exhibited a fully filled state, while less than 5% exhibited an incompletely filled state, defined as funneling or bridging...

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Abstract

The present invention relates to an expansible hollow part, having at least one opening, which consists of an elastic biocompatible material and which comprises at least one biologically active substance and, optionally at least one matrix compound. The invention also provides a method of producing said expansible hollow part, a medical device covered at least partially with said hollow part, a kit-of-parts comprising said hollow part of the invention and the use of said hollow part as a therapeutic device and for protecting a medical device.

Description

technical field [0001] The invention relates to an expandable hollow part having at least one opening, which consists of an elastic biocompatible material and which comprises at least one biologically active substance and optionally at least one matrix compound. The invention also provides a method of manufacturing said expandable hollow part, a medical device at least partially covered by said hollow part, a kit comprising said hollow part according to the invention and said hollow part as a therapeutic device and for protecting medical devices. The purpose of the device. Background technique [0002] Diseased blood vessels, narrowing of blood vessels, and certain organ failures such as those caused by stenosis can now be administered systemically and by introducing balloon catheters or metal stents (either of which can be coated with a suitable pharmaceutical substance) and allowing them to Dilatation, to expand and support the affected vessel segment or organ lumen, or b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M31/00A61L31/14A61L29/14A61F2/82
CPCA61N1/375A61F2250/0068A61L31/146A61F2/82A61L31/16A61M25/10A61B2017/00526A61M2025/0057A61L2300/00A61M2025/105A61M25/0045A61B17/12109A61B17/12136A61L31/14A61M2025/1031A61L29/146B05D3/12A61B2017/00893A61M2025/0056A61F2250/0067A61L29/16A61M25/1036A61L29/14A61M25/104A61N1/37512A61P9/00
Inventor 托尔斯滕·海尔曼克里斯蒂安·里克特萨比娜·波斯特
Owner AVIDAL VASCULAR