Amlodipine and losartan-containing compound preparation for treating hypertension

A technology of amlodipine and compound preparations, which is applied in the field of compound preparations containing amlodipine and losartan for the treatment of hypertension, can solve the problems of non-optimal ratio, low blood pressure control rate, poor patient compliance, etc., and achieve Reduce adverse reactions, high blood pressure compliance rate, quick effect

Inactive Publication Date: 2011-05-04
邬林祥 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when several drugs are taken at the same time, the patient's compliance is poor, and the dosage of several drugs is often not the optimal ratio due to the problem of the dosage of the preparation and the degree of recognition of the doctor.
In recent years, although there are many new antihypertensive drugs with good efficacy and few side effects, the rate of blood pressure control is relatively low

Method used

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  • Amlodipine and losartan-containing compound preparation for treating hypertension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-4

[0010] Embodiment 1-4 list is as follows:

[0011] In the embodiment, the conventional method in the pharmaceutical industry is used, and the formula shown in the table below is prepared into tablets, and the pharmaceutically acceptable carrier-adjuvant used for making the tablet is a conventional adjuvant in the art. Wherein the proportioning of its main components is as follows:

[0012]

[0013] Simultaneously, use conventional method in the pharmaceutical industry in the embodiment, can also be prepared into capsule, soft capsule, granule, powder, sustained and controlled release agent or injection dosage form, pharmaceutically acceptable carrier--all adjuvants used are the original formulations of this dosage form Common excipients in the field.

Embodiment 5

[0014] Embodiment 5: The curative effect test of the compound preparation of the present invention for treating hypertension:

[0015] The following will illustrate the therapeutic effect of the pharmaceutical composition of the present invention on hypertension through human pharmacodynamic experiments.

[0016] 1. General information:

[0017] Among the 400 clinical cases of hypertensive patients, 140 were 40-50 years old; 140 were 51-60 years old, and 120 were 61-70 years old.

[0018] 2. Diagnostic criteria: According to the "Guidelines for the Prevention and Treatment of Hypertension in China", hypertension is defined as: systolic blood pressure ≥ 140mmHg and / or diastolic blood pressure ≥ 90mmHg without taking antihypertensive drugs.

[0019] 3. Therapeutic method: 400 hypertensive patients are randomly divided into 4 groups, and each group adopts the compound preparation medicine obtained in Examples 1-4 of the present invention respectively to make tablets and take it ...

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PUM

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Abstract

The invention relates to an amlodipine and losartan-containing compound preparation for treating hypertension. The compound preparation comprises amlodipine or pharmaceutically-acceptable salts thereof, and hydrochlorothiazide and losartan or pharmaceutically-acceptable salts thereof which are used as main ingredients and pharmaceutically acceptable carriers. The compound preparation has the advantages that: the curative effect is improved according to the action mechanism that the medicaments are combined to ensure that the medicaments are complementary to each other to reach the standard quickly, so that the standard-reaching rate of blood pressure can reach 80 percent, the adverse effect related to increasing of a certain dosage can be conveniently reduced, and longer action time is kept. The compound preparation has the characteristics of quick response, high standard-reaching rate, small side effect, and low cost.

Description

Technical field: [0001] The invention relates to a compound preparation containing amlodipine and losartan for treating hypertension, belonging to the field of medicines. Background technique: [0002] With the rapid growth of my country's economy, drastic changes in people's lifestyles, and the acceleration of urbanization and aging, cardiovascular disease has become the first or second cause of death in urban and rural populations. Especially the patients with hypertension, whose incidence rate accounts for about 15% of the total population. With such a large disease population, it is more important to seek therapeutic drugs with significant curative effect and less side effects. [0003] At present, there are many drugs for the treatment of hypertension, such as calcium antagonists (CCBs), converting enzyme inhibitors (ACEI), angiotensin II receptor blockers (ARBs), etc., but it is difficult to achieve the standard for a single drug treatment of hypertension in the short...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/549A61K31/4422A61K31/4178A61P9/12
Inventor 邬林祥邬林云
Owner 邬林祥
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