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Method for extracting bergamottin from grapefruit peel

A technology of bergamot and grapefruit peel, which is applied in the field of extraction and purification of bergamot, can solve the problem of no subdivision and achieve the effect of complete separation and high safety

Inactive Publication Date: 2011-05-04
NANJING ZELANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, the method reported in Chinese patent CN1907138 "A Shatian pomelo peel extract and its extraction method and application" only extracts the active ingredients of Shatian pomelo by squeezing and extracting the juice, without further subdivision

Method used

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  • Method for extracting bergamottin from grapefruit peel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Get fresh pomelo peel 10kg (bergamotin content 2.1%) and pack into extraction jar, seal, CO 2 After being purified by the purifier, it is cooled and liquefied in the liquefaction tank. into the storage tank with a high-pressure metering pump to CO 2 Send it into the preheater, heat it to 40°C through the preheater, enter the extraction tank from the lower part of the extraction tank, gradually control the pressure of the extraction tank to 20MPa with a pressure regulating valve, and stabilize the pressure in the separation tower at 8MPa, and extract dynamically for 2 hours. After shutting down, 888g of precipitated solid was released as crude product, which was dispersed in 4.5L of 80% ethanol, mixed with a small amount of polyamide resin, evaporated to dryness, and the polyamide resin with a column volume of 5L was successively washed with 10L deionized water, 10% ethanol, 60 % ethanol for elution, collect 60% ethanol eluate, concentrate under reduced pressure to obta...

Embodiment 2

[0031] Get fresh pomelo peel 10kg (bergamotin content 2.2%) and pack into extraction jar, seal, CO 2 After being purified by the purifier, it is cooled and liquefied in the liquefaction tank. into the storage tank with a high-pressure metering pump to CO 2 Send it into the preheater, heat it to 45°C through the preheater, enter the extraction tank from the lower part of the extraction tank, gradually control the pressure of the extraction tank to 35MPa with a pressure regulating valve, stabilize the pressure in the separation tower at 9MPa, and extract dynamically for 2.5 hours. After shutting down, 910g of precipitated solid was released as a crude product, which was dispersed in 7L of 90% ethanol, mixed with a small amount of polyamide resin, evaporated to dryness, and adsorbed by polyamide resin with a volume of 5L on the column. % ethanol for elution, collect 75% ethanol eluate, concentrate under reduced pressure to extract, recrystallize 4 times with petroleum ether, and...

Embodiment 3

[0033] Get fresh pomelo peel 10kg (bergamotin content 2.0%) and pack into extraction jar, seal, CO 2 After being purified by the purifier, it is cooled and liquefied in the liquefaction tank. into the storage tank with a high-pressure metering pump to CO 2 Send it into the preheater, heat it to 40°C through the preheater, enter the extraction tank from the lower part of the extraction tank, gradually control the pressure of the extraction tank to 30MPa with a pressure regulating valve, and stabilize the pressure in the separation tower at 10MPa, and extract dynamically for 2 hours. After shutting down, 918g of precipitated extract was released as a crude product, dispersed in 6.4L of 85% ethanol, mixed with a small amount of polyamide resin, evaporated to dryness, and adsorbed by polyamide resin with a volume of 5L on the column, followed by 12L deionized water and 40% ethanol , 80% ethanol eluate, collect 80% ethanol eluate, concentrate under reduced pressure to extractum, r...

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Abstract

The invention relates to a method for extracting bergamottin from grapefruit peel. The method comprises the following processes of: dynamically extracting the grapefruit peel by using supercritical CO2 to obtain crude extract, separating the crude extract by using polyamide resin, eluting the crude extract by using deionized water, a 10 to 40 percent ethanol solution and a 60 to 80 percent ethanol solution in turn, collecting high ethanol eluent, re-crystallizing the eluent for 3 to 5 times by using petroleum ether, and drying the crystal under reduced pressure to obtain a product. The method for producing the bergamottin has the advantages of simple process, low carbon, environmental friendliness and safer production.

Description

Technical field: [0001] The present invention relates to the extraction and purification process of bergamot, in particular to a process using supercritical CO 2 A method for extracting and purifying bergamot by technology and polyamide separation technology. Background technique: [0002] Pomelo is the mature fruit of pomelo, a plant of Rutaceae, which is produced in southern my country such as Fujian, Jiangxi, Guangdong, and Guangxi. Grapefruit is fragrant, sweet and sour, cool, nutritious, and has high medicinal value. It is one of the precious fruits that people like to eat, and it is also recognized by the medical field as the most therapeutically beneficial fruit. [0003] According to modern pharmacological analysis, the flesh and skin of pomelo are rich in citrus aurantium, new orange peel and carotene, B vitamins, vitamin C, minerals, sugars and volatile oils. Pomelo peel is similar to other flavonoids and has anti-inflammatory effect. Pomelo peel compound has str...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/04
CPCY02P20/54
Inventor 刘东锋张翼杨成东
Owner NANJING ZELANG MEDICAL TECH
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