Application of shiandra for preparing medicaments for resisting tumor invasion and metastasis

An anti-tumor and Schisandra chinensis technology, applied in the directions of anti-tumor drugs, drug combinations, drug delivery, etc., can solve problems such as drugs without tumor metastasis, and achieve the effect of good clinical application prospects.

Inactive Publication Date: 2011-05-11
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Tumor is one of the major diseases caused by human beings, and tumor metastasis is the main cause of death of patients, but there is no effective anti-tumor metastasis clinically
At present, there is no report that Schisandra chinensis and biphenyl cyclooctadiene lignans have anti-tumor invasion and metastasis effects

Method used

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  • Application of shiandra for preparing medicaments for resisting tumor invasion and metastasis
  • Application of shiandra for preparing medicaments for resisting tumor invasion and metastasis
  • Application of shiandra for preparing medicaments for resisting tumor invasion and metastasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] experimental method:

[0064] Twenty Balb / c mice (purchased from the Shanghai Experimental Animal Center of the Chinese Academy of Sciences) were randomly divided into two groups, 10 in each group, and the same amount of mouse breast cancer 4T1 cells (from the Cancer Institute of Zhejiang University) were inoculated into the right armpit. )5×10 4 / only. Schisandrin B (also known as Schisandrin B, Schisandrin B, SchB, purchased from Shanghai Ronghe Pharmaceutical Technology Development Co., Ltd.) was dissolved in 0.5% Poloxamer (purchased from Sigma, USA) solvent. The control group (Control) was gavaged with 0.5% poloxamer solution at 200ul / rat / time. The Schizandrin group (SchB) was administered with 100 mg / kg Schizandrin B by intragastric administration. The above administrations all started on the second day after the tumor cells were inoculated, and the administration method was the administration on the next day, and ended after a total of 7 administrations. Thirt...

Embodiment 2

[0068] experimental method:

[0069] Forty-eight Balb / c mice were randomly divided into 6 groups, 8 in each group, and were inoculated with the same amount of 4T1 cells (5×10 4 / only). The control group (Control) was gavaged with 0.5% Poloxamer (Poloxamer) solvent 200ul / rat / time. The Schizandrin B group (SchB) was administered by intragastric administration of 100 mg / kg Schizandrin B. The above administrations all started on the second day after the tumor cells were inoculated, and were administered on the next day, and ended after a total of 7 administrations. 10 days, 14 days, and 16 days after the inoculation of tumor cells, surgical operations were performed to remove the axillary solid tumor and suture the incision. Thirty-five days after the inoculation of tumor cells, the mice were sacrificed by decapitation, and dissected to observe the metastasis of lung tumors.

[0070] Experimental results:

[0071] Compared with the control group, the solid tumor was surgicall...

Embodiment 3

[0073] experimental method:

[0074] Forty-eight Balb / c mice were randomly divided into 6 groups, 8 in each group, and were inoculated with the same amount of 4T1 cells (5×10 4 / only). The 10-day group underwent surgical resection of solid tumors 10 days after inoculation. The 15-day group underwent surgical resection of solid tumors 15 days after inoculation. The 20-day group underwent surgical resection of solid tumors 20 days after inoculation. The above three treatment methods were set up at the same time as the control group (Control) and Schizandrin B group (SchB). On the 2nd day after tumor cell inoculation, the Schisandrin B group was administrated with 100 mg / kg of Schisandrin B, and the control group was administrated with 0.5% Poloxamer solution 200ul / carp / time. medication. The administration was given every other day, and the administration ended after a total of 7 administrations. Observe survival. When the mice died, they were dissected to observe the meta...

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Abstract

The invention provides an application of shiandra and dibenzocyclooctadiene lignans for preparing medicaments for resisting tumor invasion and metastasis. When the dibenzocyclooctadiene lignans are used for preparing medicaments for resisting tumor invasion and metastasis, a mixture of two or more than two compounds can also be adopted. In the invention, the application of the shiandra and dibenzocyclooctadiene lignans for preparing medicaments for resisting tumor invasion and metastasis has the following beneficial effects: the shiandra and dibenzocyclooctadiene lignans can effectively prevent and control tumor invasion and metastasis and have good clinical application prospects.

Description

(1) Technical field [0001] The invention relates to the application of schisandra chinensis and biphenyl cyclooctadiene lignan in the preparation of anti-tumor invasion and metastasis medicine. (2) Background technology [0002] Tumor is one of the major diseases caused by human beings, and tumor metastasis is the main cause of death of patients, but there is no effective anti-tumor metastasis clinically. It has been reported in the past that the combination of Schisandra chinensis and its active ingredient biphenylcyclooctadiene lignans with anticancer drugs can be used as a sensitizer for anticancer drugs, and can also reduce or prevent the side effects of anticancer drugs. At present, there are no reports that Schisandra chinensis and biphenyl cyclooctadiene lignans have anti-tumor invasion and metastasis effects. (3) Contents of the invention [0003] The purpose of the present invention is to provide the application of schisandra chinensis and biphenyl cyclooctadiene...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/57A61K31/09A61K31/36A61K31/235A61K31/222A61K31/365A61K9/00A61K9/20A61K9/48A61K9/16A61P35/00A61P35/04A61K131/00
Inventor 胡汛刘振
Owner ZHEJIANG UNIV
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