Stabilizer for lymph vessel

Abstract

Disclosed is a stabilizer for a lymph vessel, which comprises a Tie2 activator. Preferably, the Tie2 activator is at least one member selected from the group consisting of angiopoietin-1 (Ang-1), an extract from a plant belonging to the genus Cinnamomum, an extract from a plant Siberian ginseng, and syringaresionol.

Description

technical field [0001] The present invention provides stabilizers of lymphatic vessels comprising Tie2 activating (phosphorylating) agents. Background technique [0002] Blood is sent from the heart back to the heart through capillaries and / or veins. Separately from this vasculature, lymphatic vessels form drainage pathways for interstitial fluid. Lymphatic vessels maintain a closed circulatory system by returning interstitial fluid, protein, fat, cells, etc. leaked from blood vessels to the vascular system in peripheral tissues to maintain a certain amount of blood. In capillaries present in the skin, the outside of endothelial cells is surrounded by a basement membrane, and pericytes are attached thereto. On the other hand, in capillary lymphatic vessels, there is almost no basement membrane on the outside of endothelial cells, and no pericytes are attached. This structure is useful for efficiently taking up body fluid and / or cells from the interstitium (Non-Patent Docu...

AI Technical Summary

Problems solved by technology

However, excessive lymphatic vessel dilatation is considered to decrease its recycling function and delay edema instead (Non-Patent Document 4)

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