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Preparation method for conductive superparamagnetic nanometer gamma-ferric-oxide/polyaniline-methotrexate

A methotrexate, superparamagnetic technology, applied in electrotherapy, conductive adhesives, electrodes and other directions, can solve the problems of increasing adverse drug reactions and increasing the dosage of drugs, and achieves good electrochemical activity, good super Paramagnetism, the effect of both methods

Inactive Publication Date: 2011-05-18
YANGZHOU UNIV
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  • Abstract
  • Description
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Problems solved by technology

To increase the concentration of drugs reaching tumor cells, it is necessary to increase the dosage of drugs, which also increases the adverse reactions of drugs

Method used

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  • Preparation method for conductive superparamagnetic nanometer gamma-ferric-oxide/polyaniline-methotrexate
  • Preparation method for conductive superparamagnetic nanometer gamma-ferric-oxide/polyaniline-methotrexate
  • Preparation method for conductive superparamagnetic nanometer gamma-ferric-oxide/polyaniline-methotrexate

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Embodiment Construction

[0015] As the structural characterization of the above-mentioned product of the present invention, the above-mentioned content is explained as follows. Specific examples include infrared, X-ray diffraction, transmission electron microscopy, magnetization change with external magnetic field and conductivity measurement of γ-iron oxide / polyaniline-methotrexate, but this should not be understood as the subject of the present invention. The scope is limited to the following examples.

[0016] 1. Production process

[0017] 1. Raw materials: aniline (after being distilled under reduced pressure to colorless and stored in a refrigerator at 4 ℃ for later use), hydrochloric acid, sulfuric acid, camphorsulfonic acid, ammonia, sodium hydroxide, sodium carbonate, ammonium persulfate, γ-iron oxide, methyl Medicines such as methotrexate are all analytically pure, and the solutions are all prepared with double distilled water.

[0018] 2. Preparation of γ-iron oxide / polyaniline: the same concent...

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Abstract

The invention provides a preparation method for conductive superparamagnetic nanometer gamma-ferric-oxide / polyaniline-methotrexate and relates to the technical field of chemical synthesis, in particular to a method for synthesizing the novel gamma-ferric-oxide / polyaniline-methotrexate. The preparation method prepares the nanometer gamma-ferric-oxide / polyaniline-methotrexate with conductive superparamagnetism by a doping method. In the preparation method, a doping mechanism of polyaniline is adopted, and methotrexate is doped into the conductive superparamagnetic nanometer gamma-ferric-oxide / polyaniline. The method for fixing medicaments has the unique advantage of avoiding influence on the treatment group of the fixed methotrexate. The gamma-ferric-oxide / polyaniline-methotrexate can suspend in water for three months or even longer. The method is simple and economic; the conductive superparamagnetic nanometer gamma-ferric-oxide / polyaniline-methotrexate has good electrochemical activity and good superparamagnetism under a nearly neutral environment, can be regulated and controlled to a specific position under the control of an external magnetic field and is expected to be an ideal targeted medicament, and to treat tumors in human bodies.

Description

Technical field [0001] The invention relates to the technical field of chemical synthesis, in particular to a method for synthesizing a novel γ-iron oxide / polyaniline-methotrexate. Background technique [0002] Methotrexate is an antifolate antitumor drug, mainly used for the treatment of chorioepithelial carcinoma, malignant hydatidiform mole, various acute leukemias, breast cancer, lung cancer, gastrointestinal cancer, cervical cancer, malignant lymphoma, and arteries Intubation perfusion for head and neck cancer and liver cancer. The traditional way to treat tumors is to administer them by oral or injection. The drugs are usually distributed widely in the body, and eventually only a small amount of drugs can reach the tumor site. To increase the concentration of the drug reaching the tumor cells, it is necessary to increase the amount of drug used, which also increases the adverse drug reaction. Methotrexate kills tumor cells and also has toxic side effects on normal cells ...

Claims

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Application Information

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IPC IPC(8): A61K31/519A61K50/00A61K47/34A61P35/00
Inventor 阚锦晴郭晓霞
Owner YANGZHOU UNIV
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