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Use of aidi preparation in preparation of medicaments for treating multiple organ dysfunction syndrome in elderly

A technology for functional insufficiency and syndrome, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems of patent literature and research reports that have no therapeutic effect on senile diseases

Active Publication Date: 2012-05-30
GUIZHOU YIBAI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although previous studies have shown that Aidi preparations can be used to prepare drugs for treating tumors, regulating immunity and other diseases, there are no patent documents and research reports on the therapeutic effect of Aidi preparations on senile diseases

Method used

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  • Use of aidi preparation in preparation of medicaments for treating multiple organ dysfunction syndrome in elderly
  • Use of aidi preparation in preparation of medicaments for treating multiple organ dysfunction syndrome in elderly
  • Use of aidi preparation in preparation of medicaments for treating multiple organ dysfunction syndrome in elderly

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1: A kind of formula of Aidi preparation and its preparation

[0020] Raw materials: 500g ginseng, 15g cantharis, 1000g astragalus, 1500g acanthopanax

[0021] Preparation method: take the herbaceous herbaceous material, pulverize it, heat and reflux with 400ml 100% ethanol to extract 5 times, the extraction time is respectively: 2h, 1h, 0.5h, 0.5h, 0.5h, filter, the dregs of the medicine are set aside, and the extract is extracted with 4% Adjust the sodium hydroxide solution to pH 8-9, recover ethanol under reduced pressure, filter, add water to dilute to 1000ml, adjust to pH 6-7 with 12% hydrochloric acid solution, let stand, refrigerate, and centrifugally filter, and the supernatant is washed with 4% hydrogen Adjust the sodium oxide solution to pH 8-9, and set aside; take ginseng slices, heat and reflux with 480ml 60% ethanol to extract for 3 hours, filter, and use the dregs for standby, extract the ethanol under reduced pressure, add water to the concentr...

Embodiment 2

[0022] The protective effect of embodiment 2 Aidi preparations on the organs of aged multiple organ dysfunction syndrome (MODSE) rats

[0023] In this experiment, the method of intraperitoneal injection of zymosan was used to replicate the MODSE model of aged rats, and the effects of Aidi preparation on plasma alanine aminotransferase (ALT), creatinine (Cr), respiration (R), heart rate (HR) and tissues of MODSE rats were observed. pathological effects.

[0024] 1. Materials and reagents

[0025] 1.1 Medicines and reagents: Aidi injection, 10ml / support, prepared by the method described in the present invention; Zymosan (Zymosan A, product of Sigma Company, 2g / bottle); Creatinine (Cr) and alanine aminotransferase (ALT ) kit, provided by Nanjing Jiancheng Bioengineering Institute and Shanghai Rongsheng Biotechnology Co., Ltd., batch number: 031209, 3061051.

[0026] 1.2 Experimental animals: 60 old male SD rats, weighing 200-250g, provided by Guiyang Medical College.

[0027]...

Embodiment 3

[0056] The treatment of embodiment 3 Aidi preparations to senile multiple organ dysfunction syndrome

[0057] 1. Case selection: According to the diagnostic criteria for multiple organ dysfunction syndrome (MODSE) in the elderly proposed by Wang Shiwen (Wang Shiwen, Wang Jinda, Chen Keji, etc.). 2004 Issue 01) were screened and staged, and 41 elderly patients who were clearly diagnosed with multiple organ dysfunction syndrome were randomly divided into two groups, 22 cases in the treatment group, 12 males and 10 females, aged 65-87 years , with an average age of 71.4 years; 19 cases in the control group, 10 males and 9 females, aged 65-86 years, with an average of 70.8 years old. The number of organs with organ insufficiency was 2-4, and 36 cases were in the early stage of failure. The two groups were comparable in terms of age, gender, disease duration, and condition. Each patient suffers from 2-10 kinds of chronic diseases, most of which are respiratory system diseases, ca...

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Abstract

The invention relates to a use of an aidi preparation in the preparation of medicaments for treating senile diseases, in particular to a use of an aidi preparation in the preparation of medicaments for treating multiple organ dysfunction syndrome in the elderly, wherein the aidi preparation comprises four medicines, namely ginseng, blister beetle, membranous milkvetch root and manyprickle acanto-panax root; a new treatment way is provided for the senile diseases, and the clinical application of the aidi preparation is further expanded.

Description

technical field [0001] The invention relates to a new application of the traditional Chinese medicine Aidi preparation in the preparation of medicines for treating senile common diseases, in particular to the application of the Aidi preparations in the preparation of medicines for treating senile multiple organ insufficiency syndrome. technical background [0002] Geriatrics refers to diseases related to aging, which can occur in middle-aged and old age, and may also occur in old age, but old age is more common. With the progress of society, the improvement of living standards and the prolongation of life expectancy, the ratio of elderly people continues to increase, followed by the increase of senile diseases. These diseases are related to the pathological aging of the elderly and the decline of the immune function of the body, such as hypertension, ischemic heart disease, heart failure and other circulatory system diseases, pneumonia, chronic bronchitis, emphysema, hypoxem...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/481A61P37/04A61P43/00A61K35/64
Inventor 窦啟玲周黎亚
Owner GUIZHOU YIBAI PHARMA CO LTD
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