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Film coating method of self-expanding stent

Inactive Publication Date: 2011-06-01
苏州同科生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Solve the problem of the current self-expanding mesh stent surface coating difficulties

Method used

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  • Film coating method of self-expanding stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1 A method of coating a self-expanding stent:

[0028]Take a certain amount of degradable polymer polylactic acid used as coating material, disperse and dissolve it in dichloromethane together with stone-dissolving medicine and developing agent, obtain spinning stock solution, the concentration of spinning stock solution is 15% ( w / v), the concentration of the stone-dissolving drug is 8 mg / mL, and the concentration of the developer is 2 mg / mL; the prepared spinning stock solution is added to the syringe, and the spinneret is connected to the positive pole of the high-voltage generator; the self-expandable bile duct stent is covered Fix it on a roller with a diameter of 5mm, and the length of the roller is 40mm; fix the 7 rollers with brackets into the slots connected to the motor in turn to form a parallel roller receiver, and connect the negative pole; start the motor to make the rollers and the brackets move at a constant speed Rotate, extrude the spinning ...

Embodiment 2

[0029] Embodiment 2 A covering method of a self-expanding stent:

[0030] Weigh a certain amount of degradable polymer polylactic acid and polycaprolactone (7:3, w / w) used as a coating material, and disperse and dissolve it in trichloride together with anticancer drug doxorubicin and developer. In methane, obtain spinning stock solution, the concentration of spinning stock solution is 12% (w / v), anticancer drug doxorubicin concentration is 6mg / mL, developer concentration is 2mg / mL; The spinning stock solution that will make is added Put the spinneret into the syringe, connect the spinneret to the positive pole of the high-voltage generator; put the self-expanding esophageal stent on the roller with a diameter of 30mm and fix it, and the length of the roller is 40mm; fix the two rollers covered with the bracket to the slot connected to the motor in turn In the process, a parallel drum receiver is formed and connected to the negative pole; the motor is started to rotate the drum...

Embodiment 3

[0031] Embodiment 3 A covering method of a self-expanding stent:

[0032] Weigh a certain amount of polymer polyurethane used as a coating material, disperse and dissolve it into N, N-dimethylformamide together with the antineoplastic drug camptothecin and a developer, to obtain a spinning stock solution, a spinning stock solution The concentration of the antitumor drug camptothecin is 18% (w / v), the concentration of the antineoplastic drug camptothecin is 10 mg / mL, and the concentration of the developer is 2 mg / mL; The positive pole of the self-expanding vascular stent is set on the roller with a diameter of 3.5mm and fixed, and the length of the roller is 40mm; the four rollers covered with the bracket are sequentially fixed in the slot connected to the motor to form a side-by-side roller receiver, and Connect the negative electrode; start the motor to rotate the drum and the bracket at a constant speed, and extrude the spinning stock solution at a certain flow rate from the...

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Abstract

The invention discloses a film coating method of a self-expanding stent, which is characterized in that polymer nano-fibers are ejected by utilizing an electrostatic spinning method and cover the net structure surface of the self-expanding stent to form a polymer film. According to the film coating method of the self-expanding stent, a coating film on the outer surface of the stent is composed of the polymer nano-fibers; a fiber film is formed through ejection by utilizing the electrostatic spinning method; a tubular self-expanding stent is sleeved on a drum-type collector and used for collecting nano-fibers following the uniform rotation of the drum-type collector; a plurality of collectors can be arranged in parallel to be a parallel collect group to synchronously carry out film coating on a plurality of stents; and the nano-fibers of the stent coating film contain drugs and developers. The self-expanding film coated stent prepared by utilizing the method has the advantages of simple process, high collection efficiency, and low cost, is environmentally friendly, can be widely applied to interventional therapies of blood vessel, trachea, bronchi, esophagus, alimentary canal, bile duct, nasolacrimal duct and the like and has a wide application prospect.

Description

technical field [0001] The invention belongs to the fields of polymer materials and medical engineering, and in particular relates to a method for covering a self-expanding stent. Background technique [0002] Stent implantation is a new interventional treatment technology developed on the basis of balloon catheter angioplasty, and has become an effective method for the treatment of vascular, esophageal and other luminal stenosis diseases. In stent implantation, the adherence of the stent directly determines the success or failure of the operation, which is also the main cause of stent displacement and internal fistula. As far as the structure of the stent is concerned, the wall of the self-expanding stent has a network structure, and its wall-attachment performance is significantly better than that of the balloon-expandable stent. is still the main factor affecting its effect. In order to improve these problems, various preventive or therapeutic stents have emerged in an ...

Claims

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Application Information

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IPC IPC(8): A61L31/10A61L31/16A61L31/18D01D1/02D01D1/06D01D5/00
Inventor 任天斌李建波贾梦虹黄超
Owner 苏州同科生物科技有限公司
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