Magnetic circuit for detecting chip through nuclear magnetic resonance microscope

Abstract

The invention relates to a magnetic circuit for detecting a chip through a nuclear magnetic resonance microscope. The magnetic circuit comprises a first permanent magnet, a first shimming plate, a second shimming plate and a second permanent magnet which are arranged in turn, wherein a gap is reserved between the first shimming plate and the second shimming plate to form a working air gap; and the first permanent magnet and the second permanent magnet have the same magnetic pole direction and are connected with each other through a magnetic conductor. The magnetic circuit has a small volume and is low in manufacturing cost and maintenance cost; a magnetic field which is generated in a working region has high field strength and high magnetic field uniformity; and the requirements for detecting the chip through the nuclear magnetic resonance microscope can be met better.

Description

technical field [0001] The invention relates to a magnetic circuit for nuclear magnetic resonance detection, in particular to a magnetic circuit for a nuclear magnetic resonance microscopic detection chip. Background technique [0002] Compared with detection techniques based on optics, electrochemistry, and mass spectrometry, nuclear magnetic resonance detection methods can identify the molecular structure of unknown particles and observe the new metabolic process of biological particles, especially the non-destructive nature of biological particles during the detection process. , is becoming an important enabling technology for the detection of biological particles in a microfluidic environment, and thus the emerging discipline of nuclear magnetic resonance microscopic detection chips was born. However, traditional nuclear magnetic resonance detection equipment is bulky, expensive to manufacture and maintain, and difficult to integrate with microfluidic biomedical chips. T...

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Problems solved by technology

[0004] Although the volume of the unilateral NMR magnetic circuit is greatly reduced compared with the traditional NMR magnetic circuit, the magnetic field strength generated by this magnetic circuit is relatively small, and it is mainly used in the single-sided portable NMR instrument for non-destructive detection of large Scale objects, and when applied to nuclear magnetic resonance microscopic detection chips, too small field strength is difficult to meet the high sensitivity requirements of the chip for signal detection

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