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Antihypertensive medicine

A technology for drugs and unit preparations, applied in drug combinations, cardiovascular system diseases, etc., to reduce the first-pass effect, lower blood pressure, and improve bioavailability

Inactive Publication Date: 2011-07-20
北京华禧联合科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although each drug has an antihypertensive effect, 70% of hypertensive patients need long-term combination medication to achieve a good antihypertensive effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1 Compound Telmisartan Azedipine Tablets

[0015] Dosage per tablet (mg)

[0016] Telmisartan 40

[0017] Azedipine 8

[0018] Microcrystalline Cellulose 140

[0019] CMS-Na10

[0020] Magnesium Stearate 2

[0021] Preparation method: mix telmisartan, azedipine, microcrystalline cellulose and CMS-Na, purify water to make soft material, granulate with 20 mesh sieve, dry at 55°C, granulate with 18 mesh sieve, add stearic acid Magnesium is mixed and pressed into tablets.

Embodiment 2

[0022] Example 2 Compound Telmisartan Azedipine Tablets

[0023] Dosage per tablet (mg)

[0024] Telmisartan 20

[0025] Azedipine 30

[0026] Microcrystalline Cellulose 100

[0027] CMS-Na10

[0028] Magnesium Stearate 2

[0029] Preparation method: mix telmisartan, azedipine, microcrystalline cellulose and CMS-Na, purify water to make soft material, granulate with 20 mesh sieve, dry at 55°C, granulate with 18 mesh sieve, add stearic acid Magnesium is mixed and pressed into tablets.

Embodiment 3

[0030] Example 3 Compound Telmisartan Azedipine Tablets

[0031] Dosage per tablet (mg)

[0032] Telmisartan 80

[0033] Azhedipine 16

[0034] Microcrystalline Cellulose 180

[0035] L-HPC 20

[0036] Magnesium Stearate 2

[0037] Preparation method: mix telmisartan, azedipine, microcrystalline cellulose and L-HPC, purify water to make soft material, granulate with 20 mesh sieve, dry at 55°C, granulate with 18 mesh sieve, add stearic acid Magnesium is mixed and pressed into tablets.

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PUM

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Abstract

The invention relates to a medicine for treating hypertension, which is a compound preparation consisting of telmisartan angiotensin converting enzyme receptor inhibitor and azelnidipine calcium antagonist. When the compound preparation disclosed by the invention is used, the dose and application times of the medicine are reduced, side effects are reduced, the patient compliance is improved and the treatment effect is enhanced.

Description

technical field [0001] The invention relates to a medicine for treating hypertension, which is a compound preparation composed of angiotensin-converting enzyme receptor inhibitor telmisartan and calcium ion antagonist azedipine. Background technique [0002] Increased peripheral resistance, hypersystole, and water and sodium retention in the body are the three main pathological factors that form hypertension. At present, there are many kinds of drugs for the treatment of high blood pressure. The more commonly used ones are calcium channel blockers, β-receptor blockers, angiotensin converting enzyme inhibitors, angiotensin converting enzyme inhibitor receptor inhibitors, and diuretics. Common drugs include nifedipine, nitrendipine, captopril, valsartan, hydrochlorothiazide, etc. Although each drug has an antihypertensive effect, 70% of hypertensive patients need long-term combination medication to achieve a good antihypertensive effect. [0003] The purpose of the present i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4427A61K31/4184A61P9/12
Inventor 不公告发明人
Owner 北京华禧联合科技发展有限公司
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