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Praziquantel transdermal preparation and applications thereof

The technology of a transdermal preparation and praziquantel is applied in the field of praziquantel, which can solve the problems of inconvenient administration, low drug utilization rate, pain in livestock and the like, and achieves the effects of convenient administration, no toxic side effects and remarkable curative effect.

Inactive Publication Date: 2011-08-03
SHANGHAI VETERINARY RES INST CHINESE ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, veterinary praziquantel preparations are still tablets and powders, which have the disadvantages of poor absorption and severe first-pass effect of the liver, resulting in low drug utilization and large side effects. Ketones tend to disrupt the balance of stomach flora
Although there have been praziquantel injections with good absorption and high drug utilization, praziquantel injections still have disadvantages such as inconvenient administration and easy pain to livestock.

Method used

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  • Praziquantel transdermal preparation and applications thereof
  • Praziquantel transdermal preparation and applications thereof
  • Praziquantel transdermal preparation and applications thereof

Examples

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preparation example Construction

[0024] The preparation method of praziquantel transdermal preparation of the present invention comprises the following steps:

[0025] Heat an appropriate amount of 206 adjuvant, aqueous solution or purified water to 28°C-32°C respectively;

[0026] Mix the preheated 206 adjuvant and praziquantel, add preheated aqueous solution or purified water and mix evenly until the praziquantel transdermal preparation is obtained.

Embodiment 1

[0029] (1) Measure 54ml of 206 adjuvant; prepare 38.32ml of sterilized PBS (PH8.0); heat the above solvent to 30°C±2°C;

[0030] (2) Weigh 7.68g of praziquantel, pour it into a sterile beaker, and preheat to 30°C±2°C;

[0031] (3) Add 54ml of preheated 206 adjuvant into the beaker;

[0032] (4) Place the rotor of the FJ-200 high-speed dispersing homogenizer in a beaker containing praziquantel and 206 adjuvants;

[0033] (5) Start stirring at a low speed (200-300 rpm) and gradually add 38.32ml of preheated PBS, the flow rate of PBS is 5-10 liters / min;

[0034] (6) Accelerate to 2000 rpm and keep it for 10 minutes;

[0035] (7) Stop stirring to obtain the praziquantel transdermal preparation containing 8% (weight percentage) praziquantel, wherein the weight percentage of 206 adjuvant is 50%, and the volume percentage is 54%; At low temperature (4 ℃ ~ 12 ℃).

Embodiment 2

[0037] (1) Measure 43.2ml of 206 adjuvant; prepare 33.6ml of sterilized saline; heat the above solvent to 30°C±2°C;

[0038] (2) Weigh 23.2g of praziquantel, pour it into a sterile beaker, and preheat to 30°C±2°C;

[0039] (3) Add 43.2ml of preheated 206 adjuvant into the beaker;

[0040] (4) Place the rotor of the FJ-200 high-speed dispersing homogenizer in a beaker containing praziquantel and 206 adjuvants;

[0041] (5) Start stirring at a low speed (200-300 rpm) and gradually add 33.6ml of preheated saline, the flow rate of which is 5-10 liters / min;

[0042] (6) Accelerate to 2000 rpm and keep it for 10 minutes;

[0043] (7) Stop stirring to obtain the praziquantel transdermal preparation containing 24% (weight percentage) praziquantel, wherein the weight percentage of 206 adjuvant is 40%, and the volume percentage is 43.2%; At low temperature (4 ℃ ~ 12 ℃).

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Abstract

The invention discloses a praziquantel transdermal preparation prepared from the following components in percentage by weight: 8-35 percent of praziquantel, 40-60 percent of 206 adjuvant and 5-45 percent of aqueous solution or purified water. The invention also discloses applications of the praziquantel transdermal preparation. The praziquantel transdermal preparation provided by the invention not only is convenient to administrate, but also has the same effects on treating and blocking schistosomiasis from being propagated as an oral preparation.

Description

technical field [0001] The invention relates to praziquantel medicine for preventing and treating schistosomiasis, in particular to a praziquantel transdermal preparation and application thereof. Background technique [0002] Schistosomiasis is prevalent in 76 countries and regions including tropical and subtropical regions. It is a serious zoonotic parasitic disease with a worldwide distribution. The global threatened population is as high as 600 million people, and the number of infected people reaches 200 million. At least 20,000 people died of schistosomiasis. Before the clinical application of large-scale molluscicide and schistosomiasis vaccine is realized, anti-schistosomiasis drugs are still the main means of preventing and controlling schistosomiasis. The drugs currently used to treat schistosomiasis mainly include praziquantel, artemisinin and their derivatives such as artemether. Among these drugs, praziquantel is recommended by WHO as the drug of choice for the...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/4985A61K47/10A61K47/12A61K47/14A61K47/22A61K47/34A61K47/44A61P33/12
CPCY02A50/30
Inventor 朱传刚林矫矫陆珂李浩石耀军江艳李小红刘毅杨艺
Owner SHANGHAI VETERINARY RES INST CHINESE ACAD OF AGRI SCI
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