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Fresh radix notoginseng extract, preparation method and medicinal prescription of fresh radix notoginseng extract

A technology of extract and Panax notoginseng, which is applied in the field of medicine, can solve the problems of great differences in the types and contents of the active ingredients of Panax notoginseng saponins, and achieve the effect of less impurities, light color and increased content

Inactive Publication Date: 2011-08-10
YUNNAN QIDAN PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

60% or 70% ethanol is usually used for extraction, but due to the different selection of process parameters in the extraction process, it will directly cause a great difference in the types and contents of the active ingredients of Panax notoginseng saponins

Method used

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  • Fresh radix notoginseng extract, preparation method and medicinal prescription of fresh radix notoginseng extract
  • Fresh radix notoginseng extract, preparation method and medicinal prescription of fresh radix notoginseng extract
  • Fresh radix notoginseng extract, preparation method and medicinal prescription of fresh radix notoginseng extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] 1) Take 200kg of fresh Panax notoginseng reed head, crush it into coarse powder particles of 6-10mm, extract with 6 times the amount of 80% ethanol under heat reflux for 6 hours, recover the ethanol until it has no alcohol smell, add water to dilute to 0.20g crude drug / ml, mix Evenly, precipitate for 12 hours, centrifuge to remove impurities, and filter. The filtrate is adsorbed by D101 macroporous resin at a flow rate of 1.2BV / H, then quickly rinsed with purified water of 1 times the volume of the resin, passed through the column to remove impurities, discarded the water, and washed with 4 times the volume of 70% ethanol The collected solution was eluted and deliquified at a flow rate of 2 BV / h until no saponin was detected by TLC. Then the eluent is decolorized by passing the eluent through the D941 resin at a flow rate of 6 liters / min, adding 2 times the amount of 70-80% ethanol to rinse the resin column at the same flow rate, combining the initial flow liquid and th...

Embodiment 2

[0075] Take 200kg of fresh Panax notoginseng main root, cut into thin slices with a thickness of 1-3mm, extract with 7 times the amount of 80% ethanol under hot reflux for 8 hours, recover the ethanol until it has no alcohol smell, add water to dilute to 0.25g crude drug / ml, mix well, and precipitate for 15 hours, centrifuge to remove impurities, and filter. The filtrate is adsorbed by D101 macroporous resin at a flow rate of 1.3BV / H, then quickly rinsed with purified water of 2 times the volume of the resin, passed through the column to remove impurities, discarded the water, and used 75% ethanol solution 4 times The collected solution was eluted at a flow rate of 3BV / h until no saponin was detected by TLC. Then pass the eluent through the D941 resin at a flow rate of 7.5 liters / min for decolorization, add 2 times the amount of 75% ethanol to rinse the resin column at the same flow rate, combine the initial flow and eluent until no saponin flows out as detected by TLC Then a...

Embodiment 3

[0079] Take 200kg of fresh Panax notoginseng main root, cut into thin slices with a thickness of 1-3mm, extract with 8 times the amount of 95% ethanol under heat reflux for 10 hours, recover the ethanol until it has no alcohol smell, add water to dilute to 0.30g crude drug / ml, mix well, and precipitate for 18 hours, centrifuge to remove impurities, and filter. The filtrate is adsorbed by D101 macroporous resin at a flow rate of 1.4BV / H, then passes through the column with purified water 3 times the volume of the resin to remove impurities, and the flow rate is 4BV / h. The collected solution was eluted at a flow rate of 4 BV / h in multiple volumes until no saponin was detected by TLC. Then the eluent is decolorized by passing the eluent through the D941 resin at a flow rate of 9 liters / min, adding 3 times the amount of 70-80% ethanol to rinse the resin column at the same flow rate, and combining the initial flow and eluent until TLC detects no Until the saponin flows out; then a...

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Abstract

The invention provides a radix notoginseng extract which is extracted from fresh radix notoginseng as a raw material, and a preparation method of the radix notoginseng extract and a medicinal prescription prepared from the radix notoginseng extract as an active component. The radix notoginseng extract of the invention comprises the following components: 4-10%radix notoginseng saponin R1, 23-36% ginseng saponin Rg1, 2-5% ginseng saponin Re, 27-39% ginseng saponin Rb1 and 3-10% ginseng saponin Rd, wherein the radix notoginseng saponin R1, the ginseng saponin Rg1, the ginseng saponin Re, the ginseng saponin Rb1 and the ginseng saponin Rd account for 65-95% of the total weight. The radix notoginseng extract prepared by the method in the invention has few impurities, and total saponin component is high in impurity. The medicinal prescription prepared by the radix notoginseng extract as the active component has good curative effect and high safety.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a fresh notoginseng extract, a medicinal preparation using it as an active ingredient, and a method for extracting total saponins of notoginseng from fresh notoginseng. Background technique [0002] Panax notoginseng (Buck) F. H. Chen is a plant of the genus Araliaceae. It has the reputation of "gold does not change" and "sacred grass of the south". It is a rare Chinese medicinal material in my country and a unique Chinese medicinal material resource in Yunnan. It is mainly produced in Wenshan, Yunnan . Due to its special natural conditions, Wenshan has become the origin of traditional Chinese medicine Panax notoginseng, and its output accounts for more than 90% of the country's total output. [0003] Experts and scholars at home and abroad have conducted systematic research on the chemical components of Panax notoginseng. At present, a variety of dammarane-type trit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258
Inventor 高明菊崔秀明赵爱
Owner YUNNAN QIDAN PHARMA CO LTD
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