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Use of 2-deoxy-D-glucose in prevention and treatment of viral diseases in livestock

A poultry virus disease and glucose technology, applied in the application field of 2-deoxy-D-glucose, can solve the problems of 2-deoxy-D-glucose research and development and application that have not been reported, achieve good therapeutic effect, and promote the recovery of feed intake , significant effect

Inactive Publication Date: 2011-08-17
TIANJIN ASIAN BIOENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there are many studies on the efficacy and pharmacology of 2-deoxy-D-glucose against human viruses (herpes virus, hepatitis virus, etc.), but there are many studies on 2-deoxy-D-glucose The development and application of D-glucose for anti-viral diseases in poultry has not been reported yet

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Treatment of chicken infectious bursal disease.

[0018] Treatment test in the artificial virus model. 54 SPF chickens were artificially infected with chicken infectious bursal virus to make chickens develop chicken infectious bursal virus. At the same time, they were randomly divided into 3 groups, 18 in each group. Group A is the "2-deoxy-D-glucose" treatment group, and the mass percentage of 2-deoxy-D-glucose is 30%; Group B is the astragalus polysaccharide treatment group, and the mass percentage of astragalus polysaccharide is 30%; Group C is the control group, which is treated with normal saline. The three groups of chickens are infected with chicken infectious bursal virus at the same time. , inject "2-deoxy-D-glucose" 1.0mg / Kg chicken body weight to group A, once a day, inject stilbene polysaccharide 1.0mg / Kg chicken body weight to group B chicken, once a day, inject equal volume normal saline to group C chicken, After 3-6 days, observe the morbidity, death and...

Embodiment 2

[0024] clinical treatment trials.

[0025] Select chickens with typical chicken infectious bronchitis disease, and divide 54 chickens into 3 groups randomly. Group A takes orally 2-deoxy-D-glucose 30.0mg / Kg chicken body weight; Group B takes orally astragalus polysaccharide 30.0mg / Kg chicken body weight. Group C received normal saline orally.

[0026] Table 2 "2-deoxy-D-glucose" treatment chicken infectious bronchial disease test results

[0027] group

[0028] It can be seen from Table 2 that the effective rate of the "2-deoxy-D-glucose" test group was 83.3%, and that of the oral normal saline group was 22.2%. It can be seen that 2-deoxy-D-glucose has a good therapeutic effect on chicken infectious bronchitis.

Embodiment 3

[0030] An example of "2-deoxy-D-glucose" in the treatment of chicken Newcastle disease.

[0031] On October 10, 2008, laying hens in a farm in Tianjin had the same symptoms one after another: swollen eye sockets, coughing, snoring, decreased feed intake, and decreased egg production rate. The food intake decreased rapidly, and every 1000 chickens died 10-20 per day, and the most serious death was about 60 per day.

[0032] In view of the above phenomena, it is recommended to use 2-deoxy-D-glucose intramuscular injection, 25mg / chicken, for 2-3 days in a row. In addition, multidimensional electrolytes can quickly control death and restore the mental state of the chickens.

[0033] Analysis: Necropsy diagnosis: chicken Newcastle disease.

[0034] Summary: Similar symptoms, early detection and early treatment, intramuscular injection of 2-deoxy-D-glucose 25mg / chicken, once a day, for 2-3 consecutive days. Practice has proved that 2-deoxy-D-glucose can control the disease and red...

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PUM

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Abstract

The invention discloses the use of 2-deoxy-D-glucose in prevention and treatment of viral diseases in livestock and relates to a method for preventing and treating livestock diseases, in particular to the use of 2-deoxy-D-glucose in the prevention and treatment of chicken infectious bursal disease, chicken newcastle disease and chicken infectious bronchitis. In the use, the 2-deoxy-D-glucose is applied into chicken through intramuscular injection or oral administration according to a ratio of 1.0 to 30 mg / Kg, and the prevention and treatment effect is observed. The medicine can relieve clinical symptoms of virus infection, promote sick livestock to have food, and has a treatment effective rate of over 75.5 percent for chicken infectious bronchitis and the like. The invention has the advantages that: (1) a medicine for preventing and treating viral diseases in livestock is developed for clinical medicine; (2) the medicine is free from toxic and side effects and can be used safely, the treatment effect of the medicine is exact, and the quality of the medicine is controllable; and (3) the medicine can be applied through intramuscular injection and oral administration and is insusceptible to arousing medicine resistance.

Description

technical field [0001] The invention relates to a method for preventing and treating poultry diseases, in particular to the application of 2-deoxy-D-glucose in preventing and treating chicken infectious bursal disease, chicken Newcastle disease and chicken infectious bronchitis. Background technique [0002] Chicken infectious bursal disease, chicken Newcastle disease, and chicken infectious bronchitis are the three major diseases that endanger the poultry industry. In some areas where chickens are densely raised, they have replaced atypical Newcastle disease and ranked first in the incidence of infectious diseases. Regardless of the breed, laying hens, broiler chickens, and broiler chickens; regardless of whether they are immune or not, they may get sick. These diseases cause immunosuppression of chicks, making sick chickens more susceptible to pathogens such as Escherichia coli, adenovirus, Salmonella, and chicken coccidia. Infection, the ability to respond to vaccinations...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7004A61P31/12A61P11/00
Inventor 王文彪王丽莉
Owner TIANJIN ASIAN BIOENG