Microfluid chip and spinning method thereof

A technology of microfluidic chips and microfluidic channels, which is applied in the fields of bionics, textile fibers, material science, and microfluidics, can solve the problem that spider silk cannot be obtained in large quantities, and achieve the effect of improving the degree of bionics

Active Publication Date: 2011-08-24
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although spider silk has super strength and elas

Method used

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  • Microfluid chip and spinning method thereof
  • Microfluid chip and spinning method thereof
  • Microfluid chip and spinning method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] With the mass percent concentration of 30% regenerated silk fibroin aqueous solution as the spinning solution, the spinning solution was injected into the microfluidic chip at a flow rate of 0.5 μL / min at a temperature of 30 ° C, and the microfluidic channel of the microfluidic chip After exit extrusion, the dry spinning process is adopted, solidified into filaments in the air and wound on the upper roller; the air gap from the spinneret to the winding roller is 1cm, and the winding speed is 1cm / s.

[0032] The microfluidic chip includes a substrate and a diaphragm, the diaphragm has a groove, and the surface of the diaphragm with the groove is bonded to the substrate to form a microfluidic channel; the depth c of the whole process of the microfluidic channel is equal to 10 μm, the width b of the microfluidic channel gradually and continuously decreases from the inlet to the outlet, the inlet width is 2 mm, and the outlet width is 10 μm. In the microfluidic channel, the...

Embodiment 2

[0034] With the mass percent concentration of 60% regenerated silk fibroin aqueous solution as the spinning solution, the spinning solution was injected into the microfluidic chip at a flow rate of 10 μL / min under the temperature condition of 20 ° C, and the microfluidic channel outlet of the microfluidic chip After extrusion, the dry spinning process is used to solidify into filaments in the air and wind up on the roll; the air gap from the spinneret to the roll is 5 cm, and the winding speed is 5 cm / s.

[0035]The microfluidic chip includes a substrate and a diaphragm, the diaphragm has a groove, and the surface of the diaphragm with the groove is bonded to the substrate to form a microfluidic channel; the depth c of the whole process of the microfluidic channel is equal to 500 μm, the microfluidic channel width b gradually and continuously decreases from the inlet to the outlet, the inlet width is 1 mm, and the outlet width is 500 μm. Described microfluidic channel, the tra...

Embodiment 3

[0037] With the mass percent concentration of 45% regenerated silk fibroin aqueous solution as the spinning solution, the spinning solution was injected into the microfluidic chip at a flow rate of 5 μL / min at a temperature of 10 ° C, and the outlet of the microfluidic channel of the microfluidic chip After extrusion, the dry spinning process is used to solidify into filaments in the air and wind up on the roll; the air gap from the spinneret to the roll is 10 cm, and the winding speed is 3 cm / s.

[0038] The microfluidic chip includes a substrate and a diaphragm, the diaphragm has a groove, and the surface of the diaphragm with the groove is bonded to the substrate to form a microfluidic channel; the depth c of the whole process of the microfluidic channel is equal to 100 μm, the width b of the microfluidic channel gradually and continuously decreases from the inlet to the outlet, such as figure 1 and 2 As shown, the entrance width is 500 μm and the exit width is 250 μm. In...

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Abstract

The invention relates to a microfluid chip and a spinning method thereof, particularly to a microfluid chip, width of a microfluid passageway being gradually reduced from an inlet to an outlet, and a spinning method thereof. The microfluid chip of the invention comprises a substrate and a diaphragm, wherein the diaphragm is provided with a groove, a surface of the diaphragm, where the groove is arranged in, is bonded with the substrate to form the microfluid passageway, the depth of the whole pathway is uniform, the width (b) of the microfluid passageway is gradually reduced from the inlet tothe outlet. By the spinning method of the microfluid chip provided by the present invention, spinning stock solution is injected into the inlet of the microfluid passageway of the microfluid chip andfinally flows out from the outlet of the microfluid passageway. The microfluid chip can perform dry spinning under atmosphere condition, conduct wet spinning in polymer coagulation bath, or conduct electrostatic spinning under high voltage electric field. The chip provided by the invention is simple in preparation and low in cost. Besides, drawing and cutting conditions needed by the solution in the chip can be regulated and controlled according to the requirement of spinning technology, thus, the chip has good application prospect.

Description

technical field [0001] The invention belongs to the technical fields of microfluidics, textile fibers, material science and bionics, and relates to a microfluidic chip and a spinning method thereof, in particular to a microfluidic channel whose width gradually and continuously decreases from the inlet to the outlet. Microfluidic chip and spinning method thereof. Background technique [0002] In recent years, the application of microfluidic chips in fiber formation is attracting increasing attention. Microfluidic technology can be spun under normal temperature and pressure conditions, which is very suitable for the processing of materials such as biomacromolecules. At present, microfluidic spinning technology has been well applied in the fields of instant spinning and electrospinning. In addition, the microfluidic spinning system may regulate the composition and structure of the spinning solution through the laminar flow and diffusion characteristics of the microfluid, so a...

Claims

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Application Information

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IPC IPC(8): D01D4/02D01D5/00D01D5/04D01D5/06
Inventor 张耀鹏罗杰邵惠丽胡学超
Owner DONGHUA UNIV
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