Single nano pore sensor based on glass micro tube and manufacturing method of single nano-pore sensor
A nanopore sensor and glass microtube technology, which is applied in the direction of material electrochemical variables, can solve the problems that hinder the further development of nanochannel technology, and cannot accurately measure the channel charge density distribution and the thickness of the double layer. The method is simple and the sensitivity is high. , the effect of high structural stability
Inactive Publication Date: 2011-08-31
SOUTHEAST UNIV
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Problems solved by technology
However, it is not possible to accurately measure the charge density distribution inside the channel and the thickness of the electric double layer, which hinders the in-depth development of nanochannel technology.
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[0016] In order to make the technical means, creative features, goals and effects achieved by the present invention easy to understand, the present invention will be further described below in conjunction with specific embodiments.
[0017] The glass microtube-based single nanopore sensor of the present invention includes a glass microtube 1 , an ammeter 10 and a sensing device for detecting ion current changes in the single nanopore 3 .
[0018] Wherein, the two ends of the glass microtube 1 are tapered fluid chambers 2, the middle part is a single nanopore 3, and the two fluid chambers 2 are connected by the single nanopore 3; the ammeter 10 is used to detect the ion current in the single nanopore 3 , the two ends of the ammeter 10 are respectively connected with the two fluid chambers 2, and the two fluid chambers 2 apply a voltage through a voltage source; The connecting rod 7 and the spring 6 installed on the right end of the cantilever beam 5, a magnetized ball 8 is inst...
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Abstract
The invention discloses a single nano pore sensor based on a glass micro tube. The single nano pore sensor based on the glass micro tube is characterized by comprising the glass micro tube, a current meter, a voltage source and a sensing device, wherein both ends of the glass micro tube are tapered fluid chambers, and a single nano pore is formed on the middle part of the glass micro tube; the current meter is used for detecting ionic current in the single nano pore, and both ends of the current meter are connected with the two fluid chambers respectively; the voltage source is used for exerting voltage to the two fluid chambers; and the sensing device is used for detecting change of the ionic current in the single nano pore. The sensing device comprises a cantilever beam, a connecting rod arranged at one end of the cantilever beam and a spring arranged at the other end of the cantilever beam; a magnetic tiny ball is arranged at the other end of the connecting rod; the magnetic tiny ball is located above the single nano pore; a piezoelectric ceramic is arranged at the other end of the spring; and electrolyte is arranged in the single nano pore and the two fluid chambers. The single nano pore sensor based on the glass micro tube has lower horizontal noise influence and higher resolution; and the diameter of the single nano pore manufactured by the method is 1 to 100 nanometers, so the single nano pore is applicable to detecting different mediums.
Description
technical field [0001] The invention relates to a device for detecting molecules and a manufacturing method thereof, in particular to a glass microtube-based nanometer sensor and a manufacturing method thereof. Background technique [0002] At present, the commonly used detection method of single-channel detection technology is based on the ion current in the channel as the detection mechanism, and the current in the channel is only nA level or even pA level. The nanochannels used for detection are natural biological nanochannels or artificially prepared solid-state nanopores, but due to the different shapes and properties of these nanopores (channels), such as surface charge density, these factors will seriously affect the accuracy of the measurement, resulting in relatively large Noise can not get a good signal-to-noise ratio. Current research shows that when the concentration of KCl is high, the physical occupancy of λ-DNA will cause the solution resistance to increase, ...
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Inventor 沙菁陈云飞张磊倪中华易红
Owner SOUTHEAST UNIV