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Synergistic anti-inflammatory compositions comprising boswellia serrata extracts

A synergistic, Scylla serrata technology, applied in the direction of medical preparations containing active ingredients, drug combinations, anti-inflammatory agents, etc., can solve problems that have not been involved

Active Publication Date: 2011-08-31
LAILA NUTRACEUTICALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] However, to the knowledge of the present inventors, the prior art has not related to the control and treatment of inflammatory diseases by Boswellia extract, especially AKBA concentrated extract, together with Boswellia serrata non-acidic resin extract (BNRE) included in the present invention mixture

Method used

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  • Synergistic anti-inflammatory compositions comprising boswellia serrata extracts
  • Synergistic anti-inflammatory compositions comprising boswellia serrata extracts
  • Synergistic anti-inflammatory compositions comprising boswellia serrata extracts

Examples

Experimental program
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Effect test

example 1

[0086] Preparation of Boswellia serrata non-acid resin extract (BNRE):

[0087] Boswellia serrata gum resin (100 g) was dispersed in 600 ml of methyl isobutyl ketone (MIBK) solvent and stirred at room temperature for 60 minutes. The insoluble gum particles are separated by filtration. The methyl isobutyl ketone solution was repeatedly extracted with 2% potassium hydroxide solution (3×200 ml) to remove acidic compounds. Then the methyl isobutyl ketone layer was washed successively with water (400 mL) and brine (200 mL). Concentrate the methyl isobutyl ketone layer in vacuum at 60-70°C and remove volatile components from the oily residue at 75-85°C under vacuum to obtain Boswellia serrata non-acidic resin extract or BNRE viscous oil (12 G).

[0088] Alternatively, extract from Boswellia serrata with methanol (300 ml×3) and mix and concentrate the methanol extract to obtain gum resin (250 g). The residue (50 g) was dissolved in ethyl acetate (400 ml) and extracted three times wit...

example 2

[0095] Identification method of Boswellia serrata non-acid resin extract (BNRE):

[0096] The identification method of BNRE involves the use of the following HPLC method to identify its components, namely the main components of BNRE. The solvent gradient is as described in Table 2. Each known amount of labeled compound is analyzed separately, and the residence time and peak value of each standard compound are recorded: the known amount of BNRE sample is under similar conditions and the standard sample of each labeled substance is based on the peak value. Analyze under the comparison of time, and further by adding samples to each marker. The percentage of each marker in the sample is calculated by comparing its peak area, which is consistent with the known concentration of the standard component as shown below. The composition of BNRE is shown in Table 3.

[0097] HPLC conditions

[0098] Chromatographic Column: Ferromon Luna phenyl-hexyl liquid chromatography column, (4.6x250mm)...

example 3

[0121] Preparation of Boswellia serrata extract concentrated to 10-100% AKBA:

[0122] The standard of commercially available Boswellia serrata extract measured by titration method is 85% of total boswellic acid, and 3% of 3-O-acetyl-11-keto-β-boswellic acid (AKBA) can be selectively The concentration of AKBA to 10-100%. Analyzed by HPLC method, the mixture contained total β-boswellic acid [3-O-acetyl-11-keto-β-boswellic acid, β-boswellic acid, 3-O-acetyl-β-boswellic acid, 11-keto -β-Boswellic acid, 3-O-acetyl-11-keto-β-Boswellic acid] in the range of 45-50%. Use PCT application number #s PCT / IN02 / 00034, filed on March 5, 2002 and PCT / IN05 / 000074, filed on March 7, 2005 to selectively concentrate the mixture. To 35-45% AKBA. It is further concentrated to 45-100% AKBA by adding a chromatography step or crystallization or both concentration processes. A concentrated extract containing 10--35% 3-O-acetyl-11-keto-β-boswellic acid (AKBA) is prepared by diluting AKBA with a range ...

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Abstract

The present invention discloses synergistic nutraceutical or pharmaceutical or dietary supplement anti-inflammatory compositions comprising therapeutically effective combination of an extract selectively enriched in 3-O-acetyl-1 1-keto-ss- boswellic acid (AKBA) derived from Boswellia serrata and Boswellia serrata non- acidic resin extract (BNRE). The composition(s) can be used to prevent, control and treat inflammation and several inflammatory related diseases including asthma, osteoarthritis, rheumatoid arthritis, endothelial dysfunction and the like. The invention further discloses the amelioration of pro-inflammatory biomarker proteins or molecules, whose expression / production is altered during inflammatory diseases.

Description

Technical field [0001] The present invention discloses a synergistic nutritional product or a medicine or a dietary supplement anti-inflammatory mixture, which contains selectively concentrated 3-O-acetyl-11-one-β-boswellic acid (AKBA) Boswellia serrata and Boswellia serrata Scylla serrata non-acid resin extract (BNRE). The mixture can be used to prevent, control and treat inflammation and various diseases related to inflammation, including asthma, osteoarthritis, rheumatoid arthritis, vascular endothelial dysfunction and the like. [0002] The present invention also includes the improvement of pro-inflammatory biomarker proteins or molecules that change their expression / products in the course of inflammatory diseases. Background of the invention [0003] In the Indian medical system, the gum resin of Boswellia serrata (Olive family) has been used by practitioners for the treatment of rheumatoid arthritis and gout. Various extracts of gum resin have strong anti-inflammatory and a...

Claims

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Application Information

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IPC IPC(8): A61K36/324
CPCA61K36/324A61P1/00A61P1/02A61P1/04A61P11/00A61P11/06A61P17/00A61P17/06A61P17/14A61P17/16A61P19/02A61P19/10A61P25/06A61P29/00A61P35/00A61P37/08A61P43/00A61P9/00A61P9/10A61P9/14A61P3/10
Inventor G·R·古卡拉吉R·R·古卡拉吉V·K·R·R·古卡拉吉T·吉拉考提K·布湖帕瑟拉吉V·K·R·阿鲁瑞
Owner LAILA NUTRACEUTICALS
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