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125I particle-containing kit and application thereof

A kit and particle technology, applied in the field of medical materials, can solve problems such as tumor necrosis, blockage of tumor blood vessels, and sensitivity of tumor tissue

Inactive Publication Date: 2011-09-14
杨祚璋
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, some scholars believe that the anti-tumor effect of vertebroplasty may be due to the fact that tumor tissue is more sensitive to heat than normal tissue, and the injected bone cement directly or indirectly blocks tumor blood vessels, resulting in partial necrosis of the tumor.

Method used

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  • 125I particle-containing kit and application thereof
  • 125I particle-containing kit and application thereof
  • 125I particle-containing kit and application thereof

Examples

Experimental program
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Effect test

Embodiment 2

[0010] In order to further study and verify the content of the present invention's claim protection, a percutaneous vertebroplasty (Percutaneous Vertebroplasty, PVP) joint was established in Example 1. 125 The experimental animal model of Banna miniature pigs implanted with I seeds, to study the implementation of PVP and 125 The incidence and preventive measures of surgical complications of I seed implantation. explore 125 The relationship between radiation dose and time in radiation myelitis induced by I particle brachytherapy. In Example 2, by using the new kit, by treating patients with spinal metastases, comprehensively analyzing its curative effect in the treatment of spinal metastases, postoperative complications, and its impact on important organ functions, and further exploring the novel kit of the present invention. The advantages of the kit in the treatment of spinal metastases combined with implantation.

Description of drawings

[0011] figure 1 It is a schema...

Embodiment 1

[0016] Intraspinal implantation experiment of embodiment 1 Banna miniature pig

[0017] 1. Materials and Instruments

[0018] 1.1 Experimental materials and experimental instruments

[0019] Banna miniature pig; bone cement; 125 Particle I; Novel Kit for Percutaneous Vertebroplasty Containing 125 I particles, bone cement, contrast medium. Lead plates and protective equipment, screw-in syringe pressurization devices, vertebroplasty needles, surgical hammers, single-use sterile syringes, particle implant guns, and disposable particle source delivery needles.

[0020] 1. Experimental animals

[0021] 12 adult healthy Banna miniature pigs, weighing 20-25kg (average 22.7kg), female. The Experimental Animal Center of Kunming Medical College provided and bred them. Before the experiment, the animals were fed and observed for 1 week, and the diet, stool and exercise were normal. Preliminary experiments found that T13 was the best experimental vertebral body segment ( figure 1 ...

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Abstract

The invention discloses a 125I particle-containing kit and application thereof. The kit comprises 125I particles, bone cement polymethyl methacrylate and a contrast agent. A Banna minipig test animal model implanted by percutaneous vertebroplasty is established. By the kit, a relationship between irradiation dose and time of radiation myelitis caused by short-distance irradiation of the 125I particles is discussed. By the kit, spinal metastatic tumor patients are treated and researched; and after implantation by the percutaneous vertebroplasty, curative effect is improved and postoperative complications are reduced compared with those by the pure percutaneous vertebroplasty.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a percutaneous vertebroplasty implant containing 125 The kit of I particles and its application. The kit can be used for the treatment of spinal metastases. Background technique [0002] Percutaneous vertebroplasty (PVP) is under the monitoring of imaging equipment, percutaneous vertebral body puncture into bone cement to increase the strength of the vertebral body, stabilize the diseased vertebral body, prevent vertebral body collapse, and relieve pain. . Due to the rapid development of interventional equipment in recent years, PKP has been newly developed on the basis of PVP. PKP is based on PVP. First, the balloon is used to expand the collapsed vertebral body, push the adjacent bone, and create a space in the vertebral body. Re-inject bone cement to restore the height of the vertebral body, increase the strength of the vertebral body, etc., and relieve or relieve pain [Gan...

Claims

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Application Information

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IPC IPC(8): A61B19/02A61M36/04A61B50/30
Inventor 杨祚璋孙洪瀑张晶
Owner 杨祚璋
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