A traditional Chinese medicine composition for treating osteomyelitis and nonunion

A composition and nonunion technology, which can be used in drug combinations, pharmaceutical formulations, bone diseases, etc., can solve problems such as rare diseases, insufficient traditional accumulation in the field of traditional Chinese medicine, and inability to obtain curative effects from antibiotics.

Active Publication Date: 2021-09-24
楼基祥
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition to surgery, drug-assisted treatment is generally required, but the inflammatory site of osteomyelitis is protected by muscle, soft tissue, hyperplasia, and even bone fragments, and antibiotics alone (including slow-release antibiotics) cannot obtain significant curative effects
Although traditional Chinese medicine is good at such chronic and difficult bone diseases, due to the rare diseases caused by such high-energy trauma in ancient times, the traditional accumulation in the field of traditional Chinese medicine is insufficient.

Method used

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  • A traditional Chinese medicine composition for treating osteomyelitis and nonunion
  • A traditional Chinese medicine composition for treating osteomyelitis and nonunion
  • A traditional Chinese medicine composition for treating osteomyelitis and nonunion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1 The preparation of Chinese medicine composition of the present invention

[0021] Traditional Chinese Medicine Composition 1

[0022] (1) Weigh the required amount of medicinal materials, 20 parts of big-leaf potato, 5 parts of water keel root, 50 parts of Guling Goucatecha root, 8 parts of Wujia bark, 20 parts of Aralia thorn stem root, 10 parts of mulberry root, 10 parts of Potentilla clover, 8 parts of Achyranthes chinensis, 8 parts of mild medicine, 8 parts of astilbe, 25 parts of pearl vegetable root; add 50 parts of water and 3 parts of distiller's yeast to the big-leaf potato and Guling gourd tea root (Anqi brand liqueur / rice wine koji, powdered), fermented at 37 degrees Celsius for 10 days, took out the big-leaf potato and Guling Gouercha root, and dried in the air;

[0023] (3) Add pure water 3 times the total weight of the medicinal materials to soak the medicinal materials for 12 hours;

[0024] (4) Decoct the medicine for 2 hours, filter and p...

Embodiment 2

[0029] Example 2 Effects on fracture animal models

[0030] Fifteen male New Zealand white rabbits weighing about 2 kg were selected and divided into 3 groups. After anesthesia, the left lower limbs were shaved and disinfected. Cut the skin at the anteromedial edge of the coeloid, peel off the periosteum, expose the inner side of the upper end of the coeloid, drill a hole into the medullary cavity with a bone station, extract part of the bone marrow, and inject 50 microliters of 3% sodium morrhuate and 5 microliters into the medullary cavity 2X10 6 cfu / ml Staphylococcus aureus, the skin was sutured after the hole was closed.

[0031] After modeling, the three groups were fed with 20ml of the traditional Chinese medicine composition 1 of Example 1, the traditional Chinese medicine composition 2 of Example 1 and purified water every day, respectively, for 3 consecutive weeks.

[0032] On the day of modeling, blood was collected from the edge of the ear to detect alkaline phosp...

Embodiment 3

[0036] Embodiment 3 Chinese medicine composition of the present invention treats the clinical effect of osteomyelitis

[0037] Curative effect observation:

[0038] This clinic generally used the formula (twice a day, each 300mL) similar to the traditional Chinese medicine composition 2 of embodiment 1 when dealing with osteomyelitis before, according to the "Diagnosis and Curative Effect Criteria of Traditional Chinese Medicine Syndromes" promulgated by the State Administration of Traditional Chinese Medicine (cure: whole body Symptoms and local swelling and pain disappeared, the wound healed after ulceration, and there was no sequestrum on X-ray film; improved systemic symptoms improved, swelling and pain were relieved, but the sore was not healed; dead space and sequestrum existed on X-ray film; invalid: whole body Symptoms and local symptoms can not be controlled, X-ray film shows that the lesion does not alleviate or continue to develop), the effective rate is about 80% a...

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Abstract

The invention provides a traditional Chinese medicine composition for treating osteomyelitis and nonunion, which comprises the following raw materials in parts by weight: 15-30 parts of big-leaf potato, 3-15 parts of water keel root, and 30-120 parts of Guling Goucatecha root 3-15 servings of Radix Wujiapi, 10-60 servings of Aralia spinosa root, 3-15 servings of Sangjizi, 3-20 servings of Potentilla clover, 3-15 servings of Achyranthes bidentata, 3-10 servings of mild medicine 3-30 servings of astilbe, 3-60 servings of pearl vegetable root; among them, the big-leaf potato and Guling gourd tea root are fermented with rice wine koji to enhance drug penetration.

Description

a technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating osteomyelitis and nonunion. Two background technology [0002] Osteomyelitis (Traumatic Osteomyelitis) is a bone infectious disease, the main clinical manifestations are bone defects and subsequent nonunions, and often accompanied by fractures, soft tissue and muscle damage, etc., if it is not controlled for a long time Easily disabled. Osteomyelitis is mostly caused by high-energy injuries such as car accidents and work-related injuries during manual labor, and is becoming more and more common in modern society. [0003] The purpose of osteomyelitis treatment is to control infection, repair bone defects, restore bone continuity, and restore limb function to the greatest extent. In addition to surgery, drug-assisted treatment is generally required, but the inflammatory site of osteomyelitis is protected by mu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/81A61P19/08
CPCA61K36/12A61K36/185A61K36/21A61K36/25A61K36/254A61K36/51A61K36/72A61K36/73A61K36/81A61K2236/19A61K2236/331A61K2236/39A61P19/08A61K2300/00
Inventor 楼基祥
Owner 楼基祥
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