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Application of total flavonoids of astragalus in preparing pharmaceutical for preventing and treating acute radiation pneumonitis

A technology of radiation pneumonitis and total flavonoids, applied in the field of medical use of astragalus extract

Active Publication Date: 2012-07-25
李宝生
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, there are also patent applications related to the use of total flavonoids of Radix Astragali to prepare medicines for treating pneumonia. For example, patent 03156284.1 discloses the use of a composition of Radix Codonopsis and Astragalus in the prevention and treatment of acute lung injury, but the composition is used for the treatment of pneumonia caused by Acute lung injury caused by LPS (lipopolysaccharide, lipopolysaccharide) does not involve acute radiation pneumonitis

Method used

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  • Application of total flavonoids of astragalus in preparing pharmaceutical for preventing and treating acute radiation pneumonitis
  • Application of total flavonoids of astragalus in preparing pharmaceutical for preventing and treating acute radiation pneumonitis
  • Application of total flavonoids of astragalus in preparing pharmaceutical for preventing and treating acute radiation pneumonitis

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Extract total flavonoids from Astragalus

[0031] 1. Drug pretreatment:

[0032] Put Astragalus membranaceus in an oven, bake until the water content is below 10%, crush, pass through a 40-mesh sieve, and store in a sealed container;

[0033] 2. Alcohol extraction of total flavonoids of Radix Astragali:

[0034] 1. Accurately weigh 1000g of astragalus powder after drying and crushing, pour it into a round bottom flask, soak it in 90% ethanol for 72 hours according to the ratio of 1g:10-12ml, and stir it from time to time;

[0035] 2. After stirring, filter the solution, collect the extract, wash the filter residue with the ethanol solution of the same concentration in a volume ratio of 1: 1, and use a numerically controlled ultrasonic cleaner to ultrasonicate in a water bath at 80°C after cleaning (ultrasonic frequency is 25kHz, power is 350W) extract for 30 minutes, filter and collect the extract;

[0036] 3. Evenly put the astragalus powder extracted by ultrasoun...

Embodiment 2

[0041] The total flavonoids of Radix Astragali was obtained according to the method of Example 1, which was then dissolved in physiological saline to prepare an injection with a concentration of total flavonoids of Radix Astragali of 100 mg / L.

Embodiment 3

[0043] The total flavonoids of Radix Astragali was obtained according to the method of Example 1, which was then dissolved in physiological saline to prepare an injection with a concentration of total flavonoids of Radix Astragali of 110 mg / L.

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PUM

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Abstract

The invention discloses an application of total flavonoids of astragalus in preparing pharmaceutical for preventing and treating acute radiation pneumonitis. The total flavonoids of astragalus contains various medicinal compositions, has prevention and treatment effects on the acute radiation pneumonitis, and can obviously alleviate lung tissue inflammatory lesion, and relieve incrassation and hyperemia of alveolar wall and alveolus pulmonis clearances, and has obvious effects.

Description

technical field [0001] The invention relates to the medical use of an extract of astragalus, in particular to the application of total flavonoids of astragalus in the preparation of medicines for preventing and treating acute radiation pneumonitis. Background technique [0002] Astragalus, aliases: Cotton Qi, Mian Qi, Mian Huang Qi, Cotton Astragali, Astragali, Astragalus, Arrow Qi, Arrow Astragalus, Inner Mongolia Astragalus, Wang Sun, Dai Qi, Dai Grits, Dai Shen, Du Shen, Shuzhi, Baiben , Baiyao Mian, Baiyao Mian, Tushan Explosive Zhanggen, Single Root, Dazhao, Two People Lifting, Dayouqi, Mengqi, Yuanqi, Red Lanqi, Baipiqi, Black Piqi, Astragalus membranaceus, Northeast Astragalus, Inner Mongolia Astragalus, Chongzhengqi, Wuchuanqi, Paotaiqi, and Hunyuanqi are collectively referred to as plants and Chinese herbal medicines. The plant Astragalus is produced in Inner Mongolia, Shanxi, Gansu, Heilongjiang and other places, and is a national third-level protected plant. Ast...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/481A61P11/00
Inventor 王娟李宝生张宁
Owner 李宝生
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