Toltrazuril suspension and preparation method thereof
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A technology of toltrazuril and dry suspension, applied in the directions of drug combination, emulsion delivery, liquid delivery, etc., can solve the problem of high cost of preparation of microemulsion and suspension, clinical promotion, uneven mixing of premixes, and animal husbandry. Uneven intake of poultry and other problems, to avoid adverse pharmacological effects, fast onset, and simple methods
Active Publication Date: 2011-09-28
江苏基宇生物医药科技有限公司
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Problems solved by technology
The utilization of Toltrazil is small, the uneven mixing of the premix and the uneven dispersion of the dispersing agent will easily lead to uneven intake of livestock and poultry, thereby reducing the curative effect or causing toxic and side effects of individual livestock and poultry due to excessive intake
At present, the solutions are all dissolved by organic
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Embodiment 1
[0020] The preparation of embodiment 1 Toltrazuril dry suspension
[0021] Add 25 g of Toltrazuril (Hubei Longxiang Pharmaceutical Co., Ltd., batch number 201012181, the same below) to 25 g of anhydrous glucose (Weifang Ecological Pharmaceutical Co., Ltd., batch number 20101221, the same below), and mix well; then add xanthan Glue (Shanghai Hengsheng Chemical Co., Ltd., batch number is 20101115, the same below) 150g, add in two times, add 50g for the first time, mix evenly, add 100g, mix evenly; then add anhydrous glucose 800g, add in two times, Add 200g for the first time, and then add 600g after mixing evenly, and mix evenly to obtain 1000g of Toltrazuril dry suspension.
Embodiment 2
[0022] The preparation of embodiment 2 Toltrazuril dry suspension
[0023] Add 50g of Toltrazuril to 50g of oral glucose (Shijiazhuang Huaying United Glucose Factory, specification 25kg / bag), and mix well; then add 200g of xanthan gum, mix well; then add 700g of oral glucose, add in two , add 300g for the first time, add 400g after mixing evenly, and mix evenly to obtain Toltrazuril dry suspension 1000g.
Embodiment 3
[0024] The preparation of embodiment 3 Toltrazuril dry suspension
[0025] Add 100g of Toltrazuril to 100g of anhydrous glucose, mix well; then add 250g of hydroxypropyl methylcellulose with a viscosity coefficient of 200,000, mix well; then add 550g of anhydrous glucose, add in two times, Add 250g once, mix evenly, add 300g for the second time, mix evenly, obtain Toltrazuril dry suspension 1000g.
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Abstract
The invention discloses toltrazuril suspension, which belongs to the field of veterinary medicines and comprises the following components in percentage by mass: 2.5 to 15 percent of toltrazuril, 15.0 to 30.0 percent of suspending aid, and 65.0 to 82.5 percent of auxiliary materials. The invention also discloses the preparation method of the suspension. The suspension is administrated by mixing with drinking water, the use is convenient, the suspension is suitable for mass administration, and the labor force and materials are saved; the dosage is accurate, the toltrazuril disperses uniformly in water, and the concentration of the medicine is uniform; the absorption of the toltrazuril is desirable, the effectiveness is quick, and the bioavailability is high; in addition, compared with liquid preparation, the toltrazuril suspension is very stable and maintains a dry state constantly in a process from production to storage, and the package is sealed to prevent the suspension from contact with moisture and air. The suspension does not contain organic solvent, so the possibility of adverse pharmacological effect that may be produced by the organic solvent is lowered and the safety is high.
Description
technical field [0001] The invention belongs to the field of veterinary drug preparations, and in particular relates to a Toltrazuril dry suspension and a preparation method thereof. Background technique [0002] Common coccidiosis in veterinary clinics is mainly caused by coccidiosis of the genus Eimeria. The animal body can quickly develop immunity after exposure to the pathogen and produce protection against re-infection, so most coccidiosis outbreaks only occur in young animals. However, there is no cross-immunity between Eimeria species, and coccidiosis outbreaks caused by different species are prone to occur. The modern large-scale and closed breeding mode makes this life cycle short, making it difficult to control the disease, and the effect of conventional drug prevention, disinfection and vaccine epidemic prevention is very weak (Hui Yunyun et al. China Animal Health. 29-30 (2010)) . [0003] Toltrazuril (English name is Toltrazuril), also known as Baycox, toltra...
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