Toltrazuril suspension and preparation method thereof

Abstract

The invention discloses toltrazuril suspension, which belongs to the field of veterinary medicines and comprises the following components in percentage by mass: 2.5 to 15 percent of toltrazuril, 15.0 to 30.0 percent of suspending aid, and 65.0 to 82.5 percent of auxiliary materials. The invention also discloses the preparation method of the suspension. The suspension is administrated by mixing with drinking water, the use is convenient, the suspension is suitable for mass administration, and the labor force and materials are saved; the dosage is accurate, the toltrazuril disperses uniformly in water, and the concentration of the medicine is uniform; the absorption of the toltrazuril is desirable, the effectiveness is quick, and the bioavailability is high; in addition, compared with liquid preparation, the toltrazuril suspension is very stable and maintains a dry state constantly in a process from production to storage, and the package is sealed to prevent the suspension from contact with moisture and air. The suspension does not contain organic solvent, so the possibility of adverse pharmacological effect that may be produced by the organic solvent is lowered and the safety is high.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, and in particular relates to a Toltrazuril dry suspension and a preparation method thereof. Background technique [0002] Common coccidiosis in veterinary clinics is mainly caused by coccidiosis of the genus Eimeria. The animal body can quickly develop immunity after exposure to the pathogen and produce protection against re-infection, so most coccidiosis outbreaks only occur in young animals. However, there is no cross-immunity between Eimeria species, and coccidiosis outbreaks caused by different species are prone to occur. The modern large-scale and closed breeding mode makes this life cycle short, making it difficult to control the disease, and the effect of conventional drug prevention, disinfection and vaccine epidemic prevention is very weak (Hui Yunyun et al. China Animal Health. 29-30 (2010)) . [0003] Toltrazuril (English name is Toltrazuril), also known as Baycox, toltra...

AI Technical Summary

Problems solved by technology

The utilization of Toltrazil is small, the uneven mixing of the premix and the uneven dispersion of the dispersing agent will easily lead to uneven intake of livestock and poultry, thereby reducing the curative effect or causing toxic and side effects of individual livestock and poultry due to excessive intake

At present, the solutions are all dissolved by organic solvents, which will cause some pollution to the environment and increase the cost of auxiliary materials. At the same time, the drug is easy to precipitate when this dosage form is used for drinking water of livestock and poultry.

The cost of preparation of microemulsions and suspensions is relatively high, and there are certain limitations in clinical promotion

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