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Application of Chinese medicine composition in preparation of medicine for treating coronary heart disease malignant arrhythmia

A technique for cardiac arrhythmia and composition, which is applied in the field of preparation of drugs for the treatment of malignant arrhythmias in coronary heart disease, and can solve problems such as the application of undisclosed traditional Chinese medicine compositions, the delay of action potentials in cardiomyocytes, and the prolongation of transmembrane action potentials

Active Publication Date: 2014-11-26
HEBEI YILING MEDICINE INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

2) Hypothermia at the infarction site prolongs the duration of the transmembrane action potential
3) Localized conduction block and local extracellular hypocalcemia delay the action potential of cardiomyocytes
The above two patents do not disclose the application of the traditional Chinese medicine composition in the treatment of malignant arrhythmias in coronary heart disease

Method used

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  • Application of Chinese medicine composition in preparation of medicine for treating coronary heart disease malignant arrhythmia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1: the preparation of capsule

[0046] a) The raw material drug formula is:

[0047] Ginseng 39.6g Leech 72.6g Wood Beetle 46.2g Frankincense (made) 13.2g

[0048]Paeoniae Rubra 33g Dalbergia 13.2g Sandalwood 13.2g Scorpio 19.8g

[0049] Cicada slough 46.2g centipede 6.6g borneol 33g Suanzaoren (stir-fried) 33g;

[0050] b) Crushing process of medicinal materials:

[0051] The scorpion, leech, centipede, ground beetle, and cicada slough five kinds of insect medicines have been cleaned, washed and processed, and the frankincense prepared after cleaning is prepared according to the prescription, and crushed by a pulverizer, and the fineness of the powder reaches more than 80 mesh; The powdered medicine is ultrafinely pulverized by various ultrafine pulverization techniques, so that the average particle size of the medicine powder is less than 30-40 μm; the medicinal materials to be pulverized are washed, dried and sterilized, and the ingredients are prepared...

Embodiment 2

[0057] Embodiment 2: the preparation of tablet

[0058] a) The raw material drug formula is:

[0059] Ginseng 66g Leech 52.8g Wood Beetle 46.2g Frankincense (made) 13.2g

[0060] Radix Paeoniae Alba 33g, Dalbergia 13.2g, Sandalwood 13.2g, Scorpion 59.4g

[0061] Cicada slough 46.2g Centipede 6.6g Borneol 33g Suanzaoren (fried) 33g

[0062] b) Crushing process of medicinal materials:

[0063] The scorpion, leech, centipede, ground beetle, and cicada slough five kinds of insect medicines have been cleaned, washed and processed, and the frankincense prepared after cleaning is prepared according to the prescription, and crushed by a pulverizer, and the fineness of the powder reaches more than 80 mesh; The powdered medicine is ultrafinely pulverized by various ultrafine pulverization techniques, so that the average particle size of the medicine powder is less than 70-90 μm; the medicinal materials to be pulverized are washed, dried and sterilized, and the ingredients are prepare...

Embodiment 3

[0069] Embodiment 3: the preparation of pill

[0070] a) The raw material drug formula is:

[0071] Ginseng 39.6g Leech 66g Wood Beetle 46.2g Frankincense (made) 13.2g

[0072] Radix Paeoniae Alba 33g, Dalbergia 13.2g, Sandalwood 13.2g, Scorpion 46.2g

[0073] Cicada slough 46.2g Centipede 6.6g Borneol 33g Suanzaoren (fried) 33g

[0074] b) Crushing process of medicinal materials:

[0075] The scorpion, leech, centipede, ground beetle, and cicada slough five kinds of insect medicines have been cleaned, washed and processed, and the frankincense prepared after cleaning is prepared according to the prescription, and crushed by a pulverizer, and the fineness of the powder reaches more than 80 mesh; The powder after powder is ultrafinely pulverized by various ultrafine pulverization techniques, so that the average particle size of the powder is 10-20 μm;

[0076] c) Extraction concentration and drying process:

[0077] Add water to extract the volatile oil of Jiangxiang and s...

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Abstract

The invention discloses application of a Chinese medicine composition in preparation of a medicine for treating coronary heart disease malignant arrhythmia. The Chinese medicine composition disclosed by the invention comprises the following components of: ginseng, leech, chilopod, scorpion, ground beeltle, periostracum cicada, radix paeoniae rubra, borneol and the like, and has the curative effects of benefiting qi and activating blood circulation, and eliminating blood stasis and activating meridians. Proved by clinical experiments, the Chinese medicine composition disclosed by the invention can be used for effectively treating the coronary heart disease malignant arrhythmia.

Description

technical field [0001] The invention relates to a new application of a traditional Chinese medicine composition. Specifically, the invention relates to the application of a traditional Chinese medicine composition in preparing medicine for treating malignant arrhythmia of coronary heart disease, which belongs to the field of traditional Chinese medicine application. Background technique [0002] Malignant arrhythmia mainly refers to hemodynamically unstable ventricular tachycardia and ventricular fibrillation, which is an important cause of sudden death and one of the main causes of death in patients with arrhythmia in coronary heart disease. Most malignant arrhythmias are accompanied by organic heart disease (such as coronary heart disease, cardiomyopathy, heart failure, etc.). In recent years, many large-scale clinical trials have confirmed that amiodarone can effectively control the onset of malignant arrhythmia, improve the effect of electrical cardioversion, and reduce ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/725A61K9/48A61K9/20A61K9/16A61K9/14A61K9/08A61P9/06A61P9/10A61K35/64A61K35/62A61K31/045A61K35/646A61K35/648
Inventor 李向军郑立发安军永
Owner HEBEI YILING MEDICINE INST