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Method for extracting total anthraquinone in rhubarb from traditional Chinese medicine rhubarb by supercritical fluid

A technology of supercritical fluid and rhubarb total anthraquinone, which is applied in pharmaceutical formulations, antipyretics, antibacterials, etc., can solve the problems of low purity, low extraction rate, low efficiency, etc., and achieves a simple and specific extraction method. Strong, simple craftsmanship

Inactive Publication Date: 2011-11-16
栗进才
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the extraction rate of these processes is very low, the extraction cycle is long, the cost is high, the purity is not high, the efficiency is low, and the crude drug resources are wasted, which has become the main obstacle restricting the export of this product at this stage.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The rhubarb granule of 20g particle size 40 orders is dropped in the 5L extraction kettle of supercritical extraction device, with supercritical fluid CO 2 , for extraction, CO 2 The flow rate is 20L / h, and ethanol is added from the entrainer pump as the entrainer at the same time as the extraction. The pressure of the extraction kettle is 10MPa, the temperature is 40°C, and the extraction time is 4 hours; the high-pressure fluid containing the dissolved extract is depressurized below the critical pressure Next, enter the separation tank to separate the solute, the pressure of the separation tank is 6MPa, and the temperature is 40°C; the total anthraquinone content of rhubarb in the obtained extract / medicine solution of the tank body is 64%.

Embodiment 2

[0020] 20g particle size 30 mesh rhubarb granules are put into the 5L extraction kettle of the supercritical extraction device, with supercritical fluid CO 2 for extraction, CO 2 The flow rate is 25L / h, and ethyl acetate is added from the entrainer pump at the same time as the entrainer. The pressure of the extraction kettle is 12MPa, the temperature is 38°C, and the extraction time is 4.5 hours; the high-pressure fluid containing the dissolved extract is reduced to less than Below the critical pressure, enter the separation tank to separate the solute, the pressure of the separation tank is 10MPa, and the temperature is 35°C; the total anthraquinone content of rhubarb in the obtained extract / medicine solution of the tank body is 54%.

Embodiment 3

[0022] 20g particle size 40 mesh rhubarb granules are dropped into the extraction kettle of the supercritical extraction device, and the supercritical fluid CO 2 for extraction, CO 2 The flow rate is 20L / h. While extracting, add 90% ethanol with pH = 10 from the entrainer pump as the entrainer, the pressure of the extraction tank is 15MPa, the temperature is 40°C, and the extraction time is 4 hours; the high-pressure fluid containing the dissolved extract is decompressed below the critical pressure Next, enter the separation tank to separate the solute, the pressure of the separation tank is 7.5 MPa, and the temperature is 40 ° C; the total anthraquinone content of rhubarb in the obtained extract / medicine solution of the tank body is 81%.

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Abstract

The invention discloses a method for extracting total anthraquinone in rhubarb from the traditional Chinese medicine rhubarb by supercritical fluid. The method comprises the following steps of: putting rhubarb feed particles into an extraction kettle, continuously inputting supercritical fluid and an entrainer for extracting, reducing the pressure of the high-pressure fluid containing the dissolved extract to be lower than the critical pressure, and separating the solute product in a separation kettle. The extraction method disclosed by the invention is simple and strong in specificity, the extraction process meets the environmental requirements, and the content of total anthraquinone in rhubarb in the extract / liquid medicine is 20-90% or higher.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extraction process, in particular to a method for extracting rhubarb total anthraquinone in the traditional Chinese medicine rhubarb with a supercritical fluid. Background technique [0002] Rhubarb anthraquinones are widely found in Rhubarb palmatum (R. palmatum L.), Rhubarb tanguticum (R. tanguticum. Maxim ex Regel) and medicinal rhubarb (R. Officinal.Baill) roots and roots, studies have found that rhubarb anthraquinones have many biological activities. Among them, rhein, a representative component, has a wide range of pharmacological activities, such as anti-tumor, anti-inflammatory, anti-bacterial and regulating kidney function, etc., especially in anti-inflammatory activities have been applied. [0003] At present, for the extraction and separation of rhubarb anthraquinones, the most widely used method in my country is the systematic separation method of sulfuric acid hydrolysis, chloroform ...

Claims

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Application Information

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IPC IPC(8): A61K36/708A61P13/12A61P29/00A61P31/04A61P35/00A61K125/00
Inventor 栗进才黄鹏牛倩
Owner 栗进才
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