A safe and efficient freeze-dried fibrin sealant and preparation method thereof
A technology of fibrin and sealing agent, applied in the field of medicine, can solve the problems of inapplicability, inability to guarantee the activity of thrombin, unsatisfactory effect, etc., and achieve the effect of convenient clinical use
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Embodiment 1
[0033] formula:
[0034] Freeze-dried fibrinogen powder 13 parts, freeze-dried thrombin powder 3 parts
[0035] The freeze-dried fibrinogen powder comprises the following components in parts by weight:
[0036] 12 parts of fibrinogen, 1 part of stabilizer A;
[0037] The fibrinogen powder comes from inactivated pig plasma;
[0038] Described stabilizer A is glycine, sodium citrate and sodium chloride;
[0039] The freeze-dried thrombin powder comprises the following components in parts by weight:
[0040] 1.5 parts of thrombin, 1.5 parts of stabilizer B;
[0041] The thrombin comes from inactivated pig plasma;
[0042] The stabilizer B is glucose and dextran;
[0043] Preparation:
[0044] (1) Preparation of freeze-dried fibrinogen powder:
[0045] Add fibrinogen and stabilizer A to water, wherein the weight content of fibrinogen is 4%, mix and dissolve, then freeze-dry, and then inactivate at 100°C for 30 minutes to obtain freeze-dried fibrinogen powder;
[0046] (2)...
Embodiment 2
[0053] formula:
[0054] Freeze-dried fibrinogen powder 15 parts, freeze-dried thrombin powder 5 parts
[0055] The freeze-dried fibrinogen powder comprises the following components in parts by weight:
[0056] 13 parts of fibrinogen, 2 parts of stabilizer A;
[0057] The fibrinogen powder comes from inactivated bovine plasma;
[0058] The stabilizer A is arginine hydrochloride, sodium citrate and sodium chloride.
[0059] The freeze-dried thrombin powder comprises the following components in parts by weight:
[0060] 2.5 parts of thrombin, 2.5 parts of stabilizer B;
[0061] The thrombin comes from inactivated bovine plasma;
[0062] The stabilizer B is dextran and sucrose;
[0063] Preparation:
[0064] (1) Preparation of freeze-dried fibrinogen powder:
[0065] Add fibrinogen and stabilizer A to water, wherein the weight content of fibrinogen is 5%, mix and dissolve, then freeze-dry, and inactivate at 100°C for 30 minutes to obtain freeze-dried fibrinogen powder;
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