A kind of benidipine hydrochloride preparation and preparation method thereof

A technology of benidipine hydrochloride and preparations, applied in the field of benidipine hydrochloride preparations and its preparation, capable of solving problems such as inhibiting bone anabolism

Inactive Publication Date: 2011-12-07
张兆勇
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is known that low or intermittently high concentrations of parathyroid hormone in the blood can promote bone anabolism, but when the concentration of parathyroid hormone in the blood increases for a long time, it will inhibit bone anabolism

Method used

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  • A kind of benidipine hydrochloride preparation and preparation method thereof
  • A kind of benidipine hydrochloride preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Weigh 4 grams of benidipine hydrochloride and 1 gram of Tween-80 to 70 ml of 1,2-propanediol, stir in a water bath at 70°C to dissolve it, add 1,2-propanediol to 100 ml, let cool and pour Packed in hard capsules, each capsule contains 0.14g of liquid medicine.

Embodiment 2

[0020] Weigh 4.8 g of benidipine hydrochloride into 60 ml of polyethylene glycol 400, stir in a water bath at 65°C to dissolve it, add 400 to 100 ml of polyethylene glycol, let cool, and fill in soft capsules. Each capsule contains 0.14g of liquid medicine.

Embodiment 3

[0022] Weigh 3.5 grams of benidipine hydrochloride and 2 grams of soybean lecithin into 75 milliliters of 1,2-propanediol, ultrasonically (200W, 3min) to dissolve them, add 1,2-propanediol to 100ml, let cool and fill in In hard capsules, each capsule contains 0.14g of medicinal liquid.

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PUM

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Abstract

The invention provides a benidipine hydrochloride preparation and a preparation method thereof. The benidipine hydrochloride preparation of the present invention is composed of benidipine hydrochloride, an appropriate amount of surfactant and a solvent. After administration, the benidipine hydrochloride existing in a molecular state will dissolve rapidly and be quickly inhaled into the body, thereby achieving rapid onset of effect and improvement of The role of bioavailability. The preparation process of the benidipine hydrochloride preparation of the present invention is: dissolving benidipine hydrochloride and an appropriate amount of surfactant in a solvent by means of heating and stirring or ultrasonic probe, and filling in soft capsules or hard capsules after cooling .

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to a benidipine hydrochloride preparation and a preparation method thereof. The benidipine hydrochloride existing in a molecular state in the preparation can be rapidly dissolved and inhaled into the body. Background technique [0002] Benidipine hydrochloride belongs to the class of dihydropyridine calcium ion antagonists. It binds to dihydropyridine receptors that block cell membrane potential-dependent calcium ion channels, preventing calcium ions from flowing into cells and dilating blood vessels. Benidipine hydrochloride is widely used as a therapeutic drug for hypertension, renal hypertension, angina pectoris, etc. because of its safety and effectiveness. [0003] In the process of treating hypertension, calcium antagonists play a very important role, especially for elderly patients with essential hypertension. Studies have shown that osteoporosis is a common symptom of elderl...

Claims

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Application Information

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IPC IPC(8): A61P9/10A61P19/10A61K31/4545A61P9/12
Inventor 张震陈建明
Owner 张兆勇
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