biocompatible electrodes

A compatible, electrode technology, applied in the direction of electrodes, bioelectrical signal measurement, internal electrodes, etc.

Inactive Publication Date: 2011-12-07
UNIVERSITY OF BATH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In conclusion, there are currently no reliable, low-cost, "active" biocompatible electrodes that are structurally simple, easily mass-producible, and suitable for biosensors, implants, and electrophysiological applications (e.g. drug discovery trials)

Method used

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Examples

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Embodiment Construction

[0031] figure 1 An exemplary electrode package with a plurality of electrodes 1 is shown in . figure 2 show figure 1 An enlarged version of the box marked a in , giving a detailed description of electrode 1. image 3 show figure 2 An enlarged version of the box marked b in , giving a further detailed description of the electrode layer 2 of the electrode 1 before the electrical connection is made.

[0032] An exemplary electrode 1 includes a semiconductor substrate 3 , an insulating dielectric layer 4 and an electrode layer 2 . The electrode layer 2 has an exposed surface 5 which is arranged, in use, to be in contact with a relevant medium, such as a culture fluid supporting the cells being tested. Although the insulating layer 4 can be omitted and the electrode layer 2 can be in direct contact with the substrate 3 , the embodiments discussed herein still have the insulating layer 4 between the substrate 3 and the electrode layer 2 .

[0033] figure 1 The electrode pack...

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Abstract

A biocompatible electrode formed from an integrated circuit, the electrode comprising:a semiconductor substrate; and an electrode layer at least partially comprising porous valve metal oxide.

Description

technical field [0001] The present invention relates to biocompatible electrodes for use in applications such as electrophysiological applications, and methods for their manufacture. Background technique [0002] Various fields of biomedicine require the ability to stimulate and record from adherent cells such as neurons, cardiomyocytes, and some cell lines. Applications in these areas include drug discovery, pharmacology, cellular sensors, and neural interface systems. [0003] Over the past few years, the significant growth of the drug discovery market has been attributed to the growth of High Throughput Screening (HTS). This requires monitoring the electrophysiological response of cells to a library of compounds, and there is currently a lack of high-capacity solutions that convey the desired information related to this electrophysiological response. A single assay for HTS may contain many multiwell plates, eg, each such plate contains 384 wells. Therefore, a large num...

Claims

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Application Information

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IPC IPC(8): G01N33/487A61B5/04A61B5/0492A61N1/05A61B5/296
CPCA61N1/0551A61B5/04G01N33/4836A61B5/24
Inventor 安东尼·H·D·格雷厄姆J·泰勒克里斯·R·鲍恩乔恩·罗宾斯
Owner UNIVERSITY OF BATH
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