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Application of beta-dihydro benzoic acid macrolide derivant in preventing and treating harmful spiral shells

A harmful and control technology, applied in the field of β-m-dihydroxybenzoic acid macrolide derivative Hypothemycin, can solve the problems of heavy environmental pollution, serious harm to humans, animals, aquatic animals and plants, etc.

Active Publication Date: 2013-03-27
SOUTH CHINA BOTANICAL GARDEN CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Sodium pentachlorophenate has good molluscicidal effect and low price, but it has been banned by the World Health Organization because of its serious harm to humans, animals, aquatic animals and plants, and serious environmental pollution.
[0007] Hypothemycin was first reported as an antibacterial active substance in 1980 (Document 1: Nair M S R. Tetrahedron Letters, 1980, 21: 2011-2012), and its chemical structure was revised in 1993 (Document 2: Agatsuma T. Chem Pharm Bull, 1993, 41(2): 373-375), the study found that it has significant anti-tumor activity (document 3: Schirmer A, Proc Natl Acad Sci, 2006, 103: 4234; document 4: Tanaka H, ​​Jpn J Cancer Res, 1999, 90: 1139) and antimalarial activity (document 5: Isaka M.J Org Chem, 2002, 67: 1561), there is no report on the control of harmful snails

Method used

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  • Application of beta-dihydro benzoic acid macrolide derivant in preventing and treating harmful spiral shells
  • Application of beta-dihydro benzoic acid macrolide derivant in preventing and treating harmful spiral shells
  • Application of beta-dihydro benzoic acid macrolide derivant in preventing and treating harmful spiral shells

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: the preparation of the compound represented by formula (1) of the present invention

[0019] Inoculate Paecilomyces sp.SC0924 CGMCC No.2900 strains on 11.50L rice solid medium (rice and water with a mass ratio of 1:1), and culture at 26°C for 22 days in the dark to obtain a solid fermentation culture . The obtained solid fermentation culture was extracted 3 times with 1.5 times the volume of 95% ethanol for 24 hours each time. After the ethanol aqueous solution was concentrated under reduced pressure to remove ethanol, it was extracted 3 times with an equal volume of chloroform, and the extract was concentrated to obtain a 97.50% chloroform extract. g.

[0020] The chloroform extract was subjected to silica gel column chromatography, and gradient elution was carried out with a mixed solvent of chloroform-methanol with a volume ratio of 100:0 to 80:20, and similar fractions were detected by thin-layer chromatography, and petroleum ether was collected on a ...

Embodiment 2

[0022] Embodiment 2: the molluscicidal activity of the Hypothemycin obtained in Example 1

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Abstract

The invention relates to an application of Hypothemycin disclosed in a formula (1) in preventing and treating harmful spiral shells. An indoor dipping spiral shell killing chemical activity evaluation test proves that the compound has good activity on killing the spiral shells. The chemical is applied for 72 hours under the concentration of 10mg / L, the killing rate on the oncomelania is above 90%, and the killing rate on Ampullariidae is 100%.

Description

technical field [0001] The invention relates to a new application of Hypothemycin, a macrocyclic lactone derivative of β-m-dihydroxybenzoic acid, in particular to its new application in the prevention and control of harmful snails. Background technique [0002] Snails are a general term for mollusk gastropods, which are widely distributed in seawater, freshwater and land, and there are many kinds. Many of them can be eaten by people, used as feed or bait, but there are also many snails that are a variety of humans or livestock. Intermediate hosts of parasites, or prone to excessive reproduction leading to ecological disasters, such as snails and apple snails. [0003] Oncomelania snail is the only intermediate host of Schistosoma japonicum, and also the intermediate host of P. According to the World Health Organization estimates, about 200 million people in the world are infected with schistosomiasis, of which 120 million people show symptoms, and 600 million people are at ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N43/22A01P9/00C12P17/08C12R1/79
Inventor 徐良雄魏孝义薛璟花吴萍游晓莹
Owner SOUTH CHINA BOTANICAL GARDEN CHINESE ACADEMY OF SCI
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