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Method for detecting quality of capsules used for promoting blood circulation and stopping pain

A quality inspection method and technology for promoting blood circulation and relieving pain, which are applied in measuring devices, instruments, material analysis by electromagnetic means, etc., can solve the problems of many interference factors, difficult to be accurate, and difficult to effectively separate substances with similar structures, and achieve high separation efficiency. , good stability and fast analysis speed

Active Publication Date: 2013-05-01
NANJING ZHONGSHAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The inventor analyzes the current quality standards and finds that there are the following problems: 1) only the TLC identification is carried out to the Angelica medicinal material, which is relatively single and difficult to be accurate; The sampling environment has a great influence, and the thin layer is affected by the external temperature and humidity when unfolding, and there are many interference factors; and it is difficult to effectively separate substances with similar structures, and the inspection cycle is longer

Method used

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  • Method for detecting quality of capsules used for promoting blood circulation and stopping pain
  • Method for detecting quality of capsules used for promoting blood circulation and stopping pain
  • Method for detecting quality of capsules used for promoting blood circulation and stopping pain

Examples

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Effect test

Embodiment 1

[0091] The TLC identification of embodiment 1 frankincense

[0092] Take 2.5g of the content of this product, grind it finely, add 30ml of diethyl ether, ultrasonically treat it for 10 minutes, filter, and concentrate the filtrate to 1ml as the test solution. Simultaneously, a negative sample lacking frankincense medicinal material was made according to the preparation method of Huoxuezhitong capsule, and a negative sample solution lacking frankincense medicinal material was made according to the above-mentioned treatment method. Another 0.5 g of frankincense reference medicinal material was taken, and the reference medicinal material solution was prepared in the same way. Test according to thin-layer chromatography (Appendix VI B of "Chinese Pharmacopoeia" in 2005), draw 2 μl of the test solution and negative sample solution, and 1 μl of the reference medicinal material solution, and place them on the same silica gel G thin-layer plate respectively. Ether (30-60°C)-ethyl ace...

Embodiment 2 10

[0093] The TLC identification of embodiment 2 Panax notoginseng

[0094] Take 2.5g of the content of this product, grind it finely, add 40ml of ether, sonicate for 10 minutes, filter, evaporate the ether from the dregs, add 30ml of methanol, sonicate for 15 minutes, filter, evaporate the filtrate to dryness, add 10ml of water to dissolve, Shake and extract 2 times with water-saturated n-butanol, 15ml each time, combine the n-butanol solution, wash twice with water, 10ml each time, evaporate the n-butanol solution to dryness, add 2ml methanol to the residue to dissolve, and use it as the test solution . At the same time, according to the preparation method of Huoxue Zhitong Capsules, a negative sample of Sanqi deficiency medicinal material was prepared, and a negative sample solution of Sanqi deficiency medicinal material was prepared according to the above-mentioned treatment method. Take another 1 g of Panax notoginseng reference medicinal material, add 30 ml of methanol, an...

Embodiment 3

[0095] The TLC identification of embodiment 3 borneol

[0096] Take 1.0g of the content of this product, add petroleum ether (30-60°C) 15ml, ultrasonically treat for 2-3 minutes, filter, and the filtrate evaporates to 1ml, as the test solution. At the same time, a sample of borneol-deficient medicinal material was made according to the preparation method of Huoxuezhitong capsule, and a negative sample solution of borneol-deficient medicinal material was prepared according to the above-mentioned treatment method. Take another borneol reference substance, add petroleum ether (30-60°C) to make a solution containing 2mg per 1ml, and use it as the reference substance solution. According to the test of thin-layer chromatography (Appendix VI B of "Chinese Pharmacopoeia" 2005 edition), draw 2 μl of each of the above three solutions, and spot them on the same silica gel G thin-layer plate, add petroleum ether (30-60°C)- Ethyl acetate (19:2) was used as the developer, developed, taken ...

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Abstract

The invention discloses a method for detecting quality of capsules used for promoting blood circulation and stopping pain. The detection method provides thin-layer identification of frankincense, pseudo-ginseng and borneol and molecular identification of ground beetle, and content of ferulic acid is determined by adopting a high efficiency liquid chromatography. The quality control method disclosed by the invention can resist interference factor during separation detection, has high detection efficiency, good stability, fast analysis speed and short detection period, is reliable for controlling the quality of the capsules used for promoting blood circulation and stopping pain and creates an accurate and feasible control standard for quality detection on the capsules used for promoting blood circulation and stopping pain.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a quality detection method for Huoxuezhitong capsules. Background technique [0002] Huoxue Zhitong Capsule is the original national traditional Chinese medicine four new drugs, national traditional Chinese medicine protection varieties, prescription: Angelica 400g, frankincense (made) 80g, notoginseng 80g, borneol 20g, wood beetle 200g, natural copper (calcined) 120g, recorded in "China The Ministry of Health of the People's Republic of China Drug Standards and New Drug Standards "Volume 10 WS3-084(Z-74)-95(Z). Preparation method: the above six flavors, except borneol, and other five flavors such as angelica, are crushed into fine powder; grind borneol into fine powder, prepare with the above powder, sieve, mix, pack into capsules, and make 1000 grains (0.5g / grain); or Pack capsules and make 2000 capsules (0.25g / capsule). Instantly. [0003]...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/06G01N30/02G01N30/72G01N30/94G01N27/447
Inventor 濮存海赵开军戴瑞王波徐云辉陈磊
Owner NANJING ZHONGSHAN PHARMA CO LTD