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Application of active natural product B in preparing anti-vascular dementia products

A natural product, anti-vascular technology, applied in medical preparations containing active ingredients, food preparation, organic active ingredients, etc., can solve undiscovered problems and achieve significant social benefits

Active Publication Date: 2014-07-16
杭州双马生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0107] After literature search, so far, no active natural product B (polydatin, piceid) and its composition have been found to be directly used in the prevention, diagnosis, detection, protection, treatment and research of antifungal, antitumor, vascular dementia and Reports on senile dementia and its direct related diseases

Method used

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  • Application of active natural product B in preparing anti-vascular dementia products
  • Application of active natural product B in preparing anti-vascular dementia products
  • Application of active natural product B in preparing anti-vascular dementia products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0344] Embodiment 1, the preparation of active natural product B powder injection

[0345] Take 10g of active natural product B, add 30g of dextran, add 1500ml of water for injection, adjust the pH to 9.0, stir to dissolve; add water for injection to 2000ml, add 3.0g of activated carbon for needles, stir for 30 minutes; decarbonize and filter; Filter with a 0.22μm microporous membrane; subpackage, half-stopper; freeze-dry, then stopper and cover.

Embodiment 2

[0346] Embodiment 2, the preparation of active natural product B powder injection

[0347] Take 50g of active natural product B, add 60g of mannitol, add 5000ml of water for injection, adjust the pH to 8.0, stir to dissolve; add water for injection to 6000ml, add 1g of activated carbon for needles, and stir for 30 minutes; decarbonize and filter; use 0.22 Filter with μm microporous membrane; subpackage, half-stopper; freeze-dry, then stopper and cover.

Embodiment 3

[0348] Embodiment 3, the preparation of active natural product B powder injection

[0349] Take 1g of active natural product B, add 50g of glucose, add 900ml of water for injection, adjust the pH to 8.5, stir to dissolve; add water for injection to 1000ml, add 1.5g of activated carbon for needles, and stir for 30 minutes; decarbonize and filter; use 0.22 Filter with μm microporous membrane; subpackage, half-stopper; freeze-dry, then stopper and cover.

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Abstract

The invention relates to application of a marine fungus extract-active natural product B. The in-vitro study test indicates that the active natural product B has certain inhibiting actions on candida albicans, Cryptococcus neoformans, Trichophyton rubrum, aspergillus fumigatus and other common clinical pathogenic fungi, can inhibit growth of liver cancer, mammary cancer, lung cancer and other tumor cell strains to different degrees, can have strong protective actions on pathogenic injuries caused by rat multiple infarctional cerebral ischemia injuries and the like, can obviously improve the learning and memory functions of rats with dementia, and can be used for preparing anti-vascular dementia products. The invention provides a new medicine source for clinically resisting fungi, tumors and vascular dementia and treating directly related diseases, and has an important value for developing and utilizing medicine resources in China.

Description

[0001] This application is a divisional application of the original application "Use of Active Natural Product B for Preparation of Antifungal and Antitumor Products" (application number: 200910194849.6, filing date: August 31, 2009). technical field [0002] The present invention relates to the technical fields of medicine and food, in particular to the use of a traditional Chinese medicine extract—active natural product for the preparation of anti-vascular dementia products, and more specifically to a marine fungus extract—active natural product Natural product B, namely 4,6-Dihydroxy-3-methylene-10-propenyl-2-oxa-spiro[4,5]dec-8-ene-1,7-dione, is used to prepare anti-vascular dementia products use. Background technique [0003] (1) Research overview of marine fungi [0004] 1 Overview [0005] Marine microorganisms have great potential to produce new biologically active substances because they live in a special biological environment. For decades, nearly 600 secondary ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/365A61P25/28A61P9/10A23L1/30
Inventor 秦路平游飞冯建平徐丽莉
Owner 杭州双马生物科技股份有限公司