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Cockroach extractive and prepared oral care composition as well as preparation method and applications

An oral care and extract technology is applied in the field of cockroach extraction and pharmacy to achieve the effects of repairing oral ulcers and preventing bleeding gums

Active Publication Date: 2012-01-04
YUNNAN TENGCHONG PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Modern scientific research shows that cockroach extracts have strong biological activity, but the application of cockroach extracts in the prior art still has great limitations, and the biologically active substances extracted from cockroaches have not been developed to have anti-inflammatory properties. , repair oral ulcers, and prevent gum bleeding, so the application potential of cockroach extract needs to be further developed and utilized

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] 1000 g of dried cockroach worms are crushed into coarse powder, extracted with 70% ethanol at a weight ratio of 5 times under reflux for 8 hours, the filtrate is concentrated under reduced pressure at 60 ° C to a relative density of 1.0 to 1.2 to obtain a crude paste, and the crude paste is poured into oil and water Separator, add 6 times by weight of purified water and stir well, let stand for 12 hours, remove the bottom sediment and upper layer of grease, collect the brown liquid in the middle layer, then add activated carbon, stir well and let it stand for 1 hour until the liquid is colorless and decolorized The medicinal solution is loaded into a D101 type macroporous resin column, eluted with water, the eluate is collected, and concentrated under reduced pressure to a relative density of 1.0-1.2 to obtain the cockroach extract essence.

Embodiment 2

[0018] The dried cockroach worms were crushed into coarse powder, extracted with 10 times the weight ratio of 95% ethanol under heat reflux for 10 hours, and the filtrate was concentrated under reduced pressure at 80°C to a relative density of 1.0 to 1.2 to obtain a crude paste, which was poured into an oil-water separator. , add 10 times by weight of purified water and stir well, let stand for 24 hours, remove the bottom sediment and upper layer of grease, collect the brown liquid in the middle layer, then add activated carbon, stir well and stand for 2 hours until the liquid is colorless and decolorized liquid Load the D101-1 macroporous resin column, elute with water, collect the eluate, and concentrate under reduced pressure to a relative density of 1.0-1.2 to obtain the cockroach extract essence.

Embodiment 3

[0020] 1000 g of dried cockroach worms are crushed into coarse powder, heated to 70 ℃ for 9 hours with 8 times the weight ratio of 80% ethanol, and the filtrate is concentrated under reduced pressure to a relative density of 1.0 to 1.2 to obtain a crude paste, which is introduced into oil-water separation Add 8 times by weight of purified water and stir well, let stand for 18 hours, remove the bottom sediment and upper grease, collect the brown liquid in the middle layer, then add activated carbon, stir well and let it stand for 1.5 hours until the liquid is colorless; decolorizing agent The liquid was loaded into a D1300 macroporous resin column, eluted with water, the eluate was collected, and concentrated under reduced pressure to a relative density of 1.0-1.2 to obtain the cockroach extract essence.

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PUM

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Abstract

The invention provides a cockroach extractive and a prepared oral care composition as well as a preparation method and applications. The preparation of the cockroach extractive comprises the following steps: heating, refluxing and extracting coarse powder of dried cockroach with 70%-95% ethanol, filtering, and concentrating while decompressing to obtain a crude paste; carrying out oil-water separation on the crude paste; removing the sediment at the bottom layer and grease at the upper layer; collecting brown liquid medicine at the middle layer; then adding active carbon for decolorizing, filling to a macroporous resin column, and eluting with water; and collecting eluate, and concentrating while decompressing to obtain cockroach extractive refined paste. The oral care composition comprises 0.1-10% of cockroach extractive, 0.5-1.5% of carboxymethylcellulose, 15-25% of glycerin, 0.1-0.3% of methyl parahydroxybenzoate, 0.05-0.15% of propyl p-hydroxybenzoate, 0.3-1.0% of sodium lauryl sulfate, 35-45% of calcium hydrogen phosphate dihydrate, 3-8% of anhydrous dicalcium phosphate, 3-8% of silicon dioxide, 0.1-0.3% of saccharin, and 1.0-1.5% of essence. The oral care composition is used for preventing and treating gum bleeding, resisting inflammation, and repairing canker sore.

Description

technical field [0001] The invention belongs to the technical field of cockroach extraction and pharmacy, and in particular relates to an extraction of biological active substances from cockroaches for preparing an oral care composition, which is used for preventing and treating gum bleeding, anti-inflammatory and repairing oral ulcers. Background technique [0002] The cockroach, also known as the American cockroach (commonly known as cockroach,) is the largest in the cockroach family, with an adult body length of 29-35 mm. The epidermis of the cockroach contains sclera and chitin, bromine, zinc, nickel, manganese, potassium, calcium, titanium, chlorine, sulfur, silicon, aluminum, magnesium and other elements, 13 kinds of amino acids can be obtained from muscle hydrolysis, and there are micro-organisms stored in the body. Vitamins B1, B2, niacin and ascorbic acid, etc. Lymph contains trehalose, trehalase, glycoprotein, inositol, protocatechuic acid glucoside, etc.; all cont...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61K8/98A61P1/02A61P29/00A61Q11/00
Inventor 邵维在李筱玲万德生段兆炜吴建忠
Owner YUNNAN TENGCHONG PHARMA FACTORY
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