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Medicinal compound preparation for treating diabetes and preparation method of medicinal compound preparation

A compound preparation, diabetes technology, applied in the field of medicine, can solve problems such as inability to completely eliminate major blood vessel complications, achieve the effects of solving adverse reactions, regulating blood lipids, and reducing side effects

Active Publication Date: 2012-03-07
BEIJING WANHUI DOUBLE CRANE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, simply controlling blood sugar cannot completely eliminate major vascular complications such as coronary heart disease in diabetic patients.

Method used

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  • Medicinal compound preparation for treating diabetes and preparation method of medicinal compound preparation
  • Medicinal compound preparation for treating diabetes and preparation method of medicinal compound preparation
  • Medicinal compound preparation for treating diabetes and preparation method of medicinal compound preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0197] Embodiment 1: the preparation of tablet of the present invention

[0198] Metformin 0.5g Atractylodes 3g Scrophulariaceae 3g Mulberry leaves 3g Ginkgo biloba 3g Alisma 3g Fenugreek 3g;

[0199] Soak Atractylodes atractylodis, mulberry leaves, and fenugreek in water for 2 hours, decoct and extract 2 times, decoct for 1.5 hours each time, add 10 times and 8 times the amount of water, filter, combine the filtrate, and concentrate the filtrate under reduced pressure to a relative density of 1.20~ 1.25 (measured at 60°C) thick paste, dried under reduced pressure, crushed through 80-mesh sieve, and set aside;

[0200] Take Scrophulariaceae and Alisma, add 70% ethanol, soak for 2 hours, reflux for 2 times, reflux for 1.5 hours each time, add alcohol 8 times, 6 times, filter, combine the filtrates, recover ethanol and concentrate to relative density It is a thick paste of 1.20-1.25 (measured at 60°C), dried under reduced pressure, crushed and passed through an 80-mesh sieve, a...

Embodiment 2

[0203] Embodiment 2: the preparation of capsule of the present invention

[0204] Metformin 0.3g Atractylodes 4g Scrophulariaceae 4g Mulberry leaves 2g Ginkgo leaves 2g

[0205] Alisma 4g Fenugreek 4g;

[0206] Soak Atractylodes atractylodis, mulberry leaves, and fenugreek in water for 1.5 hours, decoct and extract 3 times, decoct for 1 hour each time, add 7 times the amount of water each time, filter, combine the filtrate, and concentrate the filtrate under reduced pressure to a relative density of 1.20-1.25 (measured at 60°C) thick paste, dried under reduced pressure, and the dried paste was crushed through an 80-mesh sieve for subsequent use;

[0207] Take Scrophulariaceae and Alisma, add 80% ethanol, soak for 1.5 hours, reflux and extract 3 times, reflux for 1 hour each time, add alcohol 5 times each time, filter, combine the filtrates, recover ethanol and concentrate to a relative density of 1.20~1.25 (measured at 60°C) thick paste, dry under reduced pressure, crush the...

Embodiment 3

[0210] Embodiment 3: the preparation of granule of the present invention

[0211] Metformin 0.7g Atractylodes 2g Scrophulariaceae 2g Mulberry leaves 4g Ginkgo leaves 4g

[0212] Alisma 2g Fenugreek 2g;

[0213] Soak Atractylodes atractylodis, mulberry leaves, and fenugreek in water for 2.5 hours, decoct to extract once, decoct for 2 hours, add 11 times the amount of water each time, filter, combine the filtrate, and concentrate the filtrate under reduced pressure to a relative density of 1.20-1.25 (60 ℃), dried under reduced pressure, and the dried paste was crushed through an 80-mesh sieve for subsequent use;

[0214] Take Scrophulariaceae and Alisma, add 60% ethanol, soak for 2.5 hours, reflux for extraction once, reflux for 2 hours each time, add 9 times the amount of alcohol, filter, combine the filtrates, recover ethanol and concentrate to a relative density of 1.20~ 1.25 (measured at 60°C) thick paste, dried under reduced pressure, crushed through 80-mesh sieve, and se...

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Abstract

The invention discloses a medicinal compound preparation for treating diabetes, which comprises diformin, Chinese atractylodes, figwort, mulberry leaves, ginkgo leaves, rhizoma alismatis and common fenugreek seed. A clinically acceptable formulation is prepared by using the method of decoction with water, regurgitation and extraction with ethanol and purification with macroporous resin. The compound preparation has a good curative effect in the aspect of treating diabetes.

Description

technical field [0001] The invention relates to a medicine compound preparation, in particular to a compound preparation composed of metformin hydrochloride and traditional Chinese medicine, a preparation method of the compound preparation and an application in treating diabetes. The invention belongs to the field of medicine. Background technique [0002] With the development of social economy, scientific and technological progress, improvement of living standards, modernization of life style and aging society, the incidence of diabetes is increasing year by year in both developed and developing countries. The third most serious major chronic non-communicable disease after the disease. According to the data of the World Health Organization (WHO), in 1997, it was reported that there were 135 million diabetic patients in the world, 90% of which were type 2 diabetes. . According to a nationwide survey conducted in 2007-2008, the prevalence rate of diabetes in my country is ...

Claims

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Application Information

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IPC IPC(8): A61K36/884A61P3/06A61P3/10A61K31/155
Inventor 聂文辉刘君郑永熙韩春勇魏福生王义波
Owner BEIJING WANHUI DOUBLE CRANE PHARMA
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