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Synthetic method of gamma-aminobutyric acid

A technology of aminobutyric acid and synthesis method, which is applied in the field of synthesis of γ-aminobutyric acid, can solve the problems of low product purity, difficult product purification, and difficult treatment of by-product sodium acetate, and achieve the effect of shortened reaction time and concise process

Inactive Publication Date: 2012-03-21
JIANGSU YUANYANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

When this method prepares gamma-aminobutyric acid, the product is not easy to purify, the product purity is low, and the by-product sodium acetate is difficult to handle

Method used

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  • Synthetic method of gamma-aminobutyric acid

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Put 170 kg of water in a 1000L stainless steel reaction kettle with stirring, heating and devices, then add 170 kg of pyrrolidone (the concentration of the pyrrolidone aqueous solution is 50% by mass), add 204 kg of solid alkali under stirring, and then heat up to the temperature of the kettle The internal temperature is 150°C, and the reaction is continued for 6 hours, the reaction is completed, the reaction solution is obtained, the temperature is lowered, the reaction solution is filtered at 20°C to obtain a γ-aminobutyric acid solution, and then the volume of the γ-aminobutyric acid solution is adjusted at 105°C Concentrate to half, then cool and crystallize the γ-aminobutyric acid solution at 5°C, and dry to obtain 162 kg of γ-aminobutyric acid finished product. The yield was 78.6%, and the main content of γ-aminobutyric acid was 99.81%.

[0022] The reaction equation of the present embodiment is as follows:

[0023]

Embodiment 2

[0025] Put 170kg of water in a 1000L glass-lined reactor with stirring, heating and devices, then add 170KG of pyrrolidone solution, add 340 kg of solid alkali under stirring, then heat up to the temperature in the kettle at 50°C, and continue the reaction for 15 hours to end the reaction. Lower the temperature, filter the reaction solution at 30°C to obtain a γ-aminobutyric acid solution, then concentrate the volume of the γ-aminobutyric acid solution to half at 107°C, then cool the γ-aminobutyric acid solution to crystallize at 4°C , dried to obtain 160.5 kg of gamma-aminobutyric acid finished product. The yield was 77.9%, and the main content of γ-aminobutyric acid was 99.6%. All the other are the same as the description to embodiment 1.

Embodiment 3

[0027] Put 170kg of water in a 1000L stainless steel reaction kettle with stirring, heating and devices, then add 170KG of pyrrolidone solution, add 221kg of solid alkali under stirring, then heat up to the temperature in the kettle at 90°C, and continue the reaction for 12 hours , to end the reaction. Lower the temperature, filter the reaction solution at 25°C to obtain a γ-aminobutyric acid solution, then concentrate the volume of the γ-aminobutyric acid solution to half at 106°C, then cool the γ-aminobutyric acid solution to crystallize at 6°C , dried to obtain 188.6 kg of gamma-aminobutyric acid finished product. The yield is 91.55%, and the main content of γ-aminobutyric acid is 99.6%. All the other are the same as the description to embodiment 1.

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Abstract

A synthetic method of gamma-aminobutyric acid belongs to the technical field of organic chemistry catalytic synthesis. A solid base is used as a catalyst; a ring-opening reaction of a pyrrolidone aqueous solution is performed to obtain a reaction solution; the reaction solution is fitered to obtain a gamma-aminobutyric acid solution; the gamma-aminobutyric acid solution is concentrated, cooled, crystallized and dried to obtain gamma-aminobutyric acid. The advantages are that: the yield is up to above 94%; the reaction time is significantly shortened, and the process is simple because of one-step synthesis; during the synthesis, no pollutant destroying the environment is generated, and thus cleaner production is realized; the purity of the gamma-aminobutyric acid is up to above 99%.

Description

technical field [0001] The invention relates to a synthesis method of gamma-aminobutyric acid, which belongs to the technical field of organic chemical catalytic synthesis. Background technique [0002] γ-Aminobutyric acid (γ-Aminobutyric Acid, GABA for short) is a naturally occurring functional amino acid, which is the main inhibitory amino acid transmitter in the central nervous system. Plays an important role in vision formation and development. γ-aminobutyric acid exists in the rhizome of Rehmannia glutinosa of Scrophulariaceae, Cucurbitaceae, Liliaceae and other plants, and can also be obtained by reacting γ-chlorobutyronitrile with potassium phthalimide and then hydrolyzing it. γ-aminobutyric acid is widely used in pharmaceuticals, health food, convenience food, baked food and sports food ingredients; it can be made into capsules, oral liquids, powders, syrups, beverages, bread, biscuits, chocolate candy and other product forms; γ- GABA also has transient hypotensive...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C229/08C07C227/22
Inventor 王建峰司双喜陈文如任举温建华王敏文
Owner JIANGSU YUANYANG PHARMA
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