Supercharge Your Innovation With Domain-Expert AI Agents!

Preparation process of 4-nitrophenyl hydrazine hydrochloride

A technology for the preparation of nitrophenylhydrazine, which is applied in the field of preparation of nitrophenylhydrazine hydrochloride, and can solve the problems of high production cost and long reaction time

Inactive Publication Date: 2012-03-21
袁雪冲
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] p-Nitrophenylhydrazine hydrochloride is an important intermediate, especially a pharmaceutical intermediate. In the prior art, p-sulfonylaminoaniline is used as raw material, and it is prepared by diazotization reaction, sodium sulfite reduction and hydrolysis. The synthetic method of p-nitrophenylhydrazine hydrochloride has long reaction time and high production cost

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0005] Add 3.5 g of p-sulfonamidoaniline, 10 ml of water, 5 ml of 10N hydrochloric acid to a 100 ml flask, stir to dissolve, cool to below 0°C, add sodium nitrite solution, react at 0-5°C for 5 minutes, filter to remove the residue, and get Diazonium salt solution.

[0006] Sodium metabisulfite 6.5g, water 25ml, 10N sodium hydroxide 5ml stirring and dissolving to prepare sodium metabisulfite alkali solution, after cooling to 10-20 ℃, add the above diazonium salt solution, adjust the PH value of 5-8, at 20-30 After reacting at °C for 30 minutes, add 10 ml of 10N hydrochloric acid and heat to 90-105 °C. After reacting for 30 minutes, add 0.1 g of activated carbon, filter to remove slag, then cool at 10 °C, filter, purify, and dry to obtain the product. According to the size and complexity of the handicraft, you can add mesh reinforcement ribs and body ribs before injection molding. For complicated structures, split molds can be used, and two or multiple injection moldings can be u...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a preparation process of 4-nitrophenyl hydrazine hydrochloride. Aminophenyl sulfonamide as an initial raw material and is subjected to a diazo reaction, a reducing reaction and hydrolysis to obtain p-nitrophenyl hydrazine hydrochloride, wherein sodium metabisulfite is used as the reducing agent in the reducing reaction; and the reducing reaction is carried out under the conditions that the temperature is 10-35DEG C and the pH value is 5-8. The p-nitrophenyl hydrazine hydrochloride product obtained by adopting the method has high purity and low production cost.

Description

Technical field [0001] The invention belongs to a preparation method of organic chemical products, and particularly relates to a preparation process of nitrophenylhydrazine hydrochloride. Background technique [0002] P-Nitrophenylhydrazine hydrochloride is an important intermediate, especially a pharmaceutical intermediate. The prior art uses p-sulfonamidoaniline as a raw material, and is prepared by diazotization reaction, sodium sulfite reduction and hydrolysis The synthetic method of p-nitrophenylhydrazine hydrochloride has long reaction time and high production cost. Summary of the invention [0003] The problem to be solved by the present invention is to provide a preparation process of nitrophenylhydrazine hydrochloride. The p-nitrophenylhydrazine hydrochloride product obtained by the method has high purity and low production cost. [0004] The preparation process of nitrophenylhydrazine hydrochloride uses p-sulfonamidoaniline as the starting material, and undergoes diazotiz...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07C243/22C07C241/02
Inventor 袁雪冲
Owner 袁雪冲
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com