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Magnetic-ultrasonic difunctional SiO2 hollow sphere contrast agent and preparation method and application thereof

A hollow sphere and dual-function technology, applied in the field of biomedical materials, achieves the effects of good biocompatibility, suitable shell thickness and simple operation process

Inactive Publication Date: 2012-03-28
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But currently SiO 2 The research of microspheres is mainly in the aspects of drug transport and drug release, but the application of its cavity to ultrasound imaging, especially the combination of ultrasound-magnetic dual-mode imaging is rarely reported, so further research is needed

Method used

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  • Magnetic-ultrasonic difunctional SiO2 hollow sphere contrast agent and preparation method and application thereof
  • Magnetic-ultrasonic difunctional SiO2 hollow sphere contrast agent and preparation method and application thereof
  • Magnetic-ultrasonic difunctional SiO2 hollow sphere contrast agent and preparation method and application thereof

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Embodiment

[0039] Take 5g of 400nm PS microspheres with a solid content of 7% in absolute ethanol and add it to 40mL of absolute ethanol, slowly magnetically stir and heat up to 50°C. After the temperature is stable, add 0.5g tetraethyl orthosilicate (TEOS) was hydrolyzed for 10 minutes, then added 5 mL of 37% ammonia water, adjusted the pH to 8-10, continued the reaction for 30 minutes, added 0.1 g of APS, and reacted for 12 hours; the obtained product was washed twice with distilled water and absolute ethanol , lyophilized, the core-shell structure PSSiO with amino groups on the surface can be obtained 2 Microspheres, the TEM image of which is shown in figure 1 Shown, obtained by JEOL JEM-2100 transmission electron microscope test.

[0040] Take 40 mg of core-shell structure PSSiO with amino groups on the surface 2 The microspheres were dissolved in 40mL of THF, placed in a 50mL reaction kettle, reacted under hydrothermal conditions at 120°C for 8h, washed twice with distilled water ...

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Abstract

The invention discloses a magnetic-ultrasonic difunctional SiO2 hollow sphere contrast agent and a preparation method and an application thereof; the contrast agent comprises SiO2 hollow spheres; the SiO2 hollow sphere has a hollow spherical structure with an inner diameter of 100-2000 nm and a shell thickness of 10-50 nm; a magnetic material DTPA-Gd and targeting molecule RGD are coupled on the surface. The difunctional SiO2 hollow sphere contrast agent obtained by the invention has a uniform particle size, a suitable cavity dimension, a proper shell thickness, and good biocompatibility; ultrasonic imaging and magnetic resonance imaging experimental testing shows that the contrast agent can be used as a good ultrasonic-magnetic dual-mode imaging contrast agent; the experimental device of the invention is simple; the required raw materials are easily available and low in price; the operation process is simple; the by-product causes no pollution; and the invention provides an economical and practical new method for the synthesis of ultrasonic-magnetic dual-mode imaging contrast agents.

Description

technical field [0001] The invention belongs to the field of biomedical materials and relates to a magnetic-ultrasonic dual-functional SiO 2 Hollow sphere contrast agent and its preparation method and application. Background technique [0002] Molecular imaging is a new discipline developed on the basis of existing medical imaging technology in recent years. It uses specific molecules or cells as imaging sources to perform in vivo imaging of molecular level changes in living organisms and obtain their biological Actual distribution images in vivo. Therefore, molecular imaging technology is helpful for early diagnosis of diseases, promotion of drug development and analysis of life mechanism. [0003] According to different imaging principles, molecular imaging techniques can be divided into nuclear medicine, optical and magnetic resonance (MRI), ultrasound and other molecular imaging techniques. Magnetic resonance imaging is mainly based on the excitation and relaxation of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/18A61K49/08A61K49/14A61K49/22A61K103/34
Inventor 杨仕平安璐胡鹤张崇琨
Owner SHANGHAI NORMAL UNIVERSITY
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